Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 8; no. 12; pp. 894 - 903
• Main Authors: Abrantes, João A., Solms, Alexander, Garmann, Dirk, Nielsen, Elisabet I., Jönsson, Siv, Karlsson, Mats O.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2019; John Wiley and Sons Inc; Wiley
• Subjects: Age; Drug dosages; Hemophilia; Patients; Plasma; Population; Ireland

Bayesian forecasting for dose individualization of prophylactic factor VIII replacement therapy using pharmacokinetic samples is challenged by large interindividual variability in the bleeding risk. A pharmacokinetic‐repeated time‐to‐event model‐based forecasting approach was developed to contrast t...