Taurine-Induced Long-Lasting Enhancement of Synaptic Transmission in Mice: Role of Transporters

• Published in: The Journal of physiology Vol. 550; no. 3; pp. 911 - 919
• Main Authors: Sergeeva, O. A., Chepkova, A. N., Doreulee, N., Eriksson, K. S., Poelchen, W., Mönnighoff, I., Heller‐Stilb, B., Warskulat, U., Häussinger, D., Haas, H. L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK The Physiological Society 01.08.2003; Blackwell Publishing Ltd; Blackwell Science Inc
• Subjects: Algorithms; Animals; Brain Chemistry - drug effects; Carrier Proteins - genetics; Carrier Proteins - physiology; Electrophysiology; Female; Genotype; Hippocampus - drug effects; Hippocampus - metabolism; Immunohistochemistry; Male; Membrane Glycoproteins - genetics; Membrane Glycoproteins - physiology; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neostriatum - drug effects; Neostriatum - metabolism; Neuronal Plasticity - physiology; Neurotransmitter Uptake Inhibitors - pharmacology; Original; Reverse Transcriptase Polymerase Chain Reaction; Stimulation, Chemical; Synaptic Transmission - drug effects; Taurine - metabolism; Taurine - pharmacology

Taurine, a major osmolyte in the brain evokes a long-lasting enhancement (LLE TAU ) of synaptic transmission in hippocampal and cortico-striatal slices. Hippocampal LLE TAU was abolished by the GABA uptake blocker nipecotic acid (NPA) but not by the taurine-uptake inhibitor guanidinoethyl sulphonate...