Supplementation of Arachidonic Acid Plus Docosahexaenoic Acid in Cirrhotic Patients Awaiting Liver Transplantation: A Preliminary Study

• Published in: JPEN. Journal of parenteral and enteral nutrition Vol. 31; no. 6; pp. 511 - 516
• Main Authors: Pazirandeh, Sassan, Ling, Pei-Ra, Ollero, Mario, Gordon, Fredric, Burns, David L., Bistrian, Bruce R.
• Format: Journal Article
• Language: English
• Published: Silver Spring, MD SAGE Publications 01.11.2007; ASPEN; American Society for Parenteral and Enteral Nutrition
• Subjects: alpha-Linolenic Acid - administration & dosage; alpha-Linolenic Acid - adverse effects; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Arachidonic Acid - administration & dosage; Arachidonic Acid - adverse effects; Arachidonic Acid - blood; Arachidonic Acid - deficiency; Biological and medical sciences; Bone marrow, stem cells transplantation. Graft versus host reaction; C-Reactive Protein - metabolism; Dietary Supplements; Docosahexaenoic Acids - administration & dosage; Docosahexaenoic Acids - adverse effects; Docosahexaenoic Acids - blood; Double-Blind Method; Eicosapentaenoic Acid - administration & dosage; Eicosapentaenoic Acid - adverse effects; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition; Etanercept; Fatty Acids - analysis; Female; Humans; Immunoglobulin G - metabolism; Intensive care medicine; Interleukin-6 - blood; Liver Cirrhosis - blood; Liver Cirrhosis - drug therapy; Liver Transplantation; Liver, biliary tract, pancreas, portal circulation, spleen; Male; Medical sciences; Middle Aged; Phospholipids - analysis; Receptors, Tumor Necrosis Factor - metabolism; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Treatment Outcome; Triglycerides - analysis; Tumor Necrosis Factor-alpha - blood; Human; Cirrhosis; Nutrition; Digestive system; Liver; Digestive diseases; Hepatic disease; Supplementation; Arachidonic acid; Enteral administration; Parenteral administration; Feeding

Background: In patients with cirrhotic liver diseases, supplementation of linoleic acid and α-linolenic acid often does not alter the levels of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), suggesting the necessity to directly provide these nutrients. Methods: I...