VEGF、VEGF-C和VEGF-D在甲状腺乳头状癌组织中的表达及意义
R736.1; 背景与目的:研究表明血管内皮生长因子C和D(vascular endothelial growth factor-C and-D,VEGF-C,VEGF-D)与淋巴管的生成有关.局部淋巴结转移是甲状腺乳头状癌的特征,本研究的目是探讨血管内皮生长因子及其C和D(VEGF、VEGF-C和VEGF-D)蛋白在甲状腺乳头状癌的表达及其意义.方法:应用免疫组织化学SP法检测115例甲状腺乳头状癌和20例结节性甲状腺肿中VEGF、VEGF-C和VEGF-D蛋白的表达.结果:甲状腺乳头状癌VEGF、VEGF-C和VEGF-D的阳性率分别为79.1%、87.0%和72.2%.结节性甲状腺肿组织...
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| Published in | 癌症 Vol. 24; no. 9; pp. 1136 - 1139 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
广东医学院病理教研室,广东,湛江,524023
2005
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-467X |
| DOI | 10.3321/j.issn:1000-467X.2005.09.021 |
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| Abstract | R736.1; 背景与目的:研究表明血管内皮生长因子C和D(vascular endothelial growth factor-C and-D,VEGF-C,VEGF-D)与淋巴管的生成有关.局部淋巴结转移是甲状腺乳头状癌的特征,本研究的目是探讨血管内皮生长因子及其C和D(VEGF、VEGF-C和VEGF-D)蛋白在甲状腺乳头状癌的表达及其意义.方法:应用免疫组织化学SP法检测115例甲状腺乳头状癌和20例结节性甲状腺肿中VEGF、VEGF-C和VEGF-D蛋白的表达.结果:甲状腺乳头状癌VEGF、VEGF-C和VEGF-D的阳性率分别为79.1%、87.0%和72.2%.结节性甲状腺肿组织中VEGF、VEGF-C和VEGF-D的阳性率分别为30.0%、15.0%和20.0%.甲状腺乳头状癌VEGF、VEGF-C和VEGF-D的阳性率较结节性甲状腺肿明显增高.VEGF的表达与甲状腺癌的大小有关.VEGF、VEGF-C和VEGF-D在淋巴结转移组和非转移组的阳性率分别为84.7%、93.2%、83.1%和73.2%、80.4%、60.7%.VEGF-C和VEGF-D的阳性表达与甲状腺乳头状癌的淋巴结转移显著相关(P<0.05;P<0.01).结论:VEGF与甲状腺乳头状癌的生长有关.VEGF-C和VEGF-D与淋巴结转移密切相关,提示甲状腺乳头状癌标本VEGF-C和VEGF-D的检测可作为预测肿瘤转移的指标之一. |
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| AbstractList | R736.1; 背景与目的:研究表明血管内皮生长因子C和D(vascular endothelial growth factor-C and-D,VEGF-C,VEGF-D)与淋巴管的生成有关.局部淋巴结转移是甲状腺乳头状癌的特征,本研究的目是探讨血管内皮生长因子及其C和D(VEGF、VEGF-C和VEGF-D)蛋白在甲状腺乳头状癌的表达及其意义.方法:应用免疫组织化学SP法检测115例甲状腺乳头状癌和20例结节性甲状腺肿中VEGF、VEGF-C和VEGF-D蛋白的表达.结果:甲状腺乳头状癌VEGF、VEGF-C和VEGF-D的阳性率分别为79.1%、87.0%和72.2%.结节性甲状腺肿组织中VEGF、VEGF-C和VEGF-D的阳性率分别为30.0%、15.0%和20.0%.甲状腺乳头状癌VEGF、VEGF-C和VEGF-D的阳性率较结节性甲状腺肿明显增高.VEGF的表达与甲状腺癌的大小有关.VEGF、VEGF-C和VEGF-D在淋巴结转移组和非转移组的阳性率分别为84.7%、93.2%、83.1%和73.2%、80.4%、60.7%.VEGF-C和VEGF-D的阳性表达与甲状腺乳头状癌的淋巴结转移显著相关(P<0.05;P<0.01).结论:VEGF与甲状腺乳头状癌的生长有关.VEGF-C和VEGF-D与淋巴结转移密切相关,提示甲状腺乳头状癌标本VEGF-C和VEGF-D的检测可作为预测肿瘤转移的指标之一. |
| Author | 高嵋 蔡琼珍 唐慰萍 姜汉国 李飞虹 |
| AuthorAffiliation | 广东医学院病理教研室,广东,湛江,524023 |
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| Title | VEGF、VEGF-C和VEGF-D在甲状腺乳头状癌组织中的表达及意义 |
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