Comparative analysis of codon usage patterns in chloroplast genomes of five Miscanthus species and related species

Miscanthus is not only a perennial fiber biomass crop, but also valuable breeding resource for its low-nutrient requirements, photosynthetic efficiency and strong adaptability to environment. In the present study, the codon usage patterns of five different Miscanthus plants and other two related spe...

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Published inPeerJ (San Francisco, CA) Vol. 9; p. e12173
Main Authors Sheng, Jiajing, She, Xuan, Liu, Xiaoyu, Wang, Jia, Hu, Zhongli
Format Journal Article
LanguageEnglish
Published San Diego PeerJ. Ltd 23.09.2021
PeerJ, Inc
PeerJ Inc
Subjects
Adaptability
Agricultural Science
Amino acids
Analysis
Arabidopsis thaliana
Bioinformatics
Chloroplast genome
Chloroplasts
Codon
Codon optimization
Codon usage pattern
Codons
Comparative analysis
Efficiency
Evolution & development
Flowers & plants
Gene expression
Genes
Genetic engineering
Genetically altered foods
Genomes
Genomics
Miscanthus
Miscanthus species
Molecular Biology
Nutrient requirements
Photosynthesis
Plant breeding
Plant Science
Sorghum
Species
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Abstract Miscanthus is not only a perennial fiber biomass crop, but also valuable breeding resource for its low-nutrient requirements, photosynthetic efficiency and strong adaptability to environment. In the present study, the codon usage patterns of five different Miscanthus plants and other two related species were systematically analyzed. The results indicated that the cp genomes of the seven representative species were preference to A/T bases and A/T-ending codons. In addition, 21 common high-frequency codons and 4–11 optimal codons were detected in the seven chloroplast genomes. The results of ENc-plot, PR2-plot and neutrality analysis revealed the codon usage patterns of the seven chloroplast genomes are influenced by multiple factors, in which nature selection is the main influencing factor. Comparative analysis of the codon usage frequencies between the seven representative species and four model organisms suggested that Arabidopsis thaliana , Populus trichocarpa and Saccharomyces cerevisiae could be considered as preferential appropriate exogenous expression receptors. These results might not only provide important reference information for evolutionary analysis, but also shed light on the way to improve the expression efficiency of exogenous gene in transgenic research based on codon optimization.
AbstractList Miscanthus is not only a perennial fiber biomass crop, but also valuable breeding resource for its low-nutrient requirements, photosynthetic efficiency and strong adaptability to environment. In the present study, the codon usage patterns of five different Miscanthus plants and other two related species were systematically analyzed. The results indicated that the cp genomes of the seven representative species were preference to A/T bases and A/T-ending codons. In addition, 21 common high-frequency codons and 4-11 optimal codons were detected in the seven chloroplast genomes. The results of ENc-plot, PR2-plot and neutrality analysis revealed the codon usage patterns of the seven chloroplast genomes are influenced by multiple factors, in which nature selection is the main influencing factor. Comparative analysis of the codon usage frequencies between the seven representative species and four model organisms suggested that Arabidopsis thaliana, Populus trichocarpa and Saccharomyces cerevisiae could be considered as preferential appropriate exogenous expression receptors. These results might not only provide important reference information for evolutionary analysis, but also shed light on the way to improve the expression efficiency of exogenous gene in transgenic research based on codon optimization.Miscanthus is not only a perennial fiber biomass crop, but also valuable breeding resource for its low-nutrient requirements, photosynthetic efficiency and strong adaptability to environment. In the present study, the codon usage patterns of five different Miscanthus plants and other two related species were systematically analyzed. The results indicated that the cp genomes of the seven representative species were preference to A/T bases and A/T-ending codons. In addition, 21 common high-frequency codons and 4-11 optimal codons were detected in the seven chloroplast genomes. The results of ENc-plot, PR2-plot and neutrality analysis revealed the codon usage patterns of the seven chloroplast genomes are influenced by multiple factors, in which nature selection is the main influencing factor. Comparative analysis of the codon usage frequencies between the seven representative species and four model organisms suggested that Arabidopsis thaliana, Populus trichocarpa and Saccharomyces cerevisiae could be considered as preferential appropriate exogenous expression receptors. These results might not only provide important reference information for evolutionary analysis, but also shed light on the way to improve the expression efficiency of exogenous gene in transgenic research based on codon optimization.
Miscanthus is not only a perennial fiber biomass crop, but also valuable breeding resource for its low-nutrient requirements, photosynthetic efficiency and strong adaptability to environment. In the present study, the codon usage patterns of five different Miscanthus plants and other two related species were systematically analyzed. The results indicated that the cp genomes of the seven representative species were preference to A/T bases and A/T-ending codons. In addition, 21 common high-frequency codons and 4–11 optimal codons were detected in the seven chloroplast genomes. The results of ENc-plot, PR2-plot and neutrality analysis revealed the codon usage patterns of the seven chloroplast genomes are influenced by multiple factors, in which nature selection is the main influencing factor. Comparative analysis of the codon usage frequencies between the seven representative species and four model organisms suggested that Arabidopsis thaliana , Populus trichocarpa and Saccharomyces cerevisiae could be considered as preferential appropriate exogenous expression receptors. These results might not only provide important reference information for evolutionary analysis, but also shed light on the way to improve the expression efficiency of exogenous gene in transgenic research based on codon optimization.
Miscanthus is not only a perennial fiber biomass crop, but also valuable breeding resource for its low-nutrient requirements, photosynthetic efficiency and strong adaptability to environment. In the present study, the codon usage patterns of five different Miscanthus plants and other two related species were systematically analyzed. The results indicated that the cp genomes of the seven representative species were preference to A/T bases and A/T-ending codons. In addition, 21 common high-frequency codons and 4–11 optimal codons were detected in the seven chloroplast genomes. The results of ENc-plot, PR2-plot and neutrality analysis revealed the codon usage patterns of the seven chloroplast genomes are influenced by multiple factors, in which nature selection is the main influencing factor. Comparative analysis of the codon usage frequencies between the seven representative species and four model organisms suggested that Arabidopsis thaliana, Populus trichocarpa and Saccharomyces cerevisiae could be considered as preferential appropriate exogenous expression receptors. These results might not only provide important reference information for evolutionary analysis, but also shed light on the way to improve the expression efficiency of exogenous gene in transgenic research based on codon optimization.
ArticleNumber e12173
Audience Academic
Author Sheng, Jiajing
Liu, Xiaoyu
Hu, Zhongli
Wang, Jia
She, Xuan
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  givenname: Xuan
  surname: She
  fullname: She, Xuan
  organization: Wuhan University, Wuhan, China
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  organization: Anhui University of Science and Technology, Huainan, China
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  givenname: Zhongli
  surname: Hu
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  organization: Wuhan University, Wuhan, China
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Cites_doi 10.1093/nar/28.10.2084
10.1016/j.indcrop.2020.113190
10.1111/tpj.13173
10.1186/1471-2164-14-1
10.1038/nbt0901-870
10.1371/journal.pone.0080388
10.1111/j.1744-7909.2007.00404.x
10.1016/j.molcel.2015.05.035
10.15252/msb.20145524
10.1007/BF02099948
10.1073/pnas.85.8.2653
10.3390/ijms20122886
10.1038/nrg2899
10.1266/ggs.78.343
10.1007/s00425-005-0161-4
10.1007/978-0-387-70805-8_10
10.1016/j.jtbi.2013.06.006
10.1007/s00606-007-0608-0
10.1104/pp.102.017178
10.1007/s11105-017-1048-9
10.1038/s41565-019-0375-4
10.7717/peerj.8251
10.1073/pnas.0909910107
10.1038/s41598-016-0001-8
10.1111/gcbb.12101
10.1038/s41598-016-0028-x
10.1071/BT12073
10.1038/nrm3702
10.1016/S0378-1119(99)00320-0
10.1371/journal.pone.0196069
10.1016/j.plantsci.2004.03.003
10.1093/jxb/eru511
10.1042/bst0210835
10.3390/ijms19103142
10.7717/peerj.3820
10.1093/nar/17.2.477
10.1016/0378-1119(90)90491-9
10.1007/s11033-009-9521-7
10.1007/BF00163236
10.7717/peerj.3919
10.1016/j.indcrop.2021.113248
10.1371/journal.pone.0129223
10.1007/s11676-008-0052-1
10.1007/BF02715890
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References Wright (10.7717/peerj.12173/ref-39) 1990; 87
Xiang (10.7717/peerj.12173/ref-41) 2015; 10
Zhang (10.7717/peerj.12173/ref-43) 2012; 60
Sueoka (10.7717/peerj.12173/ref-34) 1995; 40
Barling (10.7717/peerj.12173/ref-3) 2013; 14
Chae (10.7717/peerj.12173/ref-4) 2014; 6
Cheng (10.7717/peerj.12173/ref-6) 2017; 5
Murray (10.7717/peerj.12173/ref-18) 1989; 17
Liu (10.7717/peerj.12173/ref-17) 2005; 84
Sharp (10.7717/peerj.12173/ref-29) 1993; 21
Ge (10.7717/peerj.12173/ref-8) 2017; 35
Shang (10.7717/peerj.12173/ref-27) 2011; 44
Zhang (10.7717/peerj.12173/ref-45) 2018; 19
Sheng (10.7717/peerj.12173/ref-31) 2021; 162
Wang (10.7717/peerj.12173/ref-38) 2020; 8
Clark (10.7717/peerj.12173/ref-7) 2015; 66
Nielsen (10.7717/peerj.12173/ref-19) 2016; 87
Plotkin (10.7717/peerj.12173/ref-21) 2011; 12
Pan (10.7717/peerj.12173/ref-20) 2013; 334
Kwak (10.7717/peerj.12173/ref-13) 2019; 14
Zhang (10.7717/peerj.12173/ref-44) 2013; 8
Quax (10.7717/peerj.12173/ref-23) 2015; 59
Liu (10.7717/peerj.12173/ref-14) 2004; 167
Chen (10.7717/peerj.12173/ref-5) 2017; 2017
Sharp (10.7717/peerj.12173/ref-28) 1986; 24
Anue (10.7717/peerj.12173/ref-2) 2019; 10
Ravi (10.7717/peerj.12173/ref-24) 2008; 271
Pop (10.7717/peerj.12173/ref-22) 2014; 10
Wu (10.7717/peerj.12173/ref-40) 2021; 161
Yan (10.7717/peerj.12173/ref-42) 2019; 20
Liu (10.7717/peerj.12173/ref-15) 2010; 37
Khodakovskaya (10.7717/peerj.12173/ref-12) 2006; 223
Zhou (10.7717/peerj.12173/ref-48) 2007; 34
Tuller (10.7717/peerj.12173/ref-36) 2010; 107
Havaux (10.7717/peerj.12173/ref-9) 2003; 132
Liu (10.7717/peerj.12173/ref-16) 2003; 30
Sheng (10.7717/peerj.12173/ref-30) 2016; 6
Ruf (10.7717/peerj.12173/ref-26) 2001; 19
Kawabe (10.7717/peerj.12173/ref-11) 2003; 78
Jarvis (10.7717/peerj.12173/ref-10) 2013; 14
Romero (10.7717/peerj.12173/ref-25) 2000; 28
Sueoka (10.7717/peerj.12173/ref-33) 1988; 85
Sheng (10.7717/peerj.12173/ref-32) 2017; 7
Sueoka (10.7717/peerj.12173/ref-35) 1999; 238
Vermerris (10.7717/peerj.12173/ref-37) 2008
Zhang (10.7717/peerj.12173/ref-46) 2007; 49
Zhou (10.7717/peerj.12173/ref-47) 2008; 19
Amiryousefi (10.7717/peerj.12173/ref-1) 2018; 13
References_xml – volume: 28
  start-page: 2084
  issue: 10
  year: 2000
  ident: 10.7717/peerj.12173/ref-25
  article-title: Codon usage in Chlamydia trachomatis is the result of strand-specific mutational biases and a complex pattern of selective forces
  publication-title: Nucleic Acids Research
  doi: 10.1093/nar/28.10.2084
– volume: 44
  start-page: 245
  issue: 2
  year: 2011
  ident: 10.7717/peerj.12173/ref-27
  article-title: Analysis on codon usage of chloroplast genome of Gossypium hirsutum
  publication-title: Scientia Agricultura Sinica
– volume: 161
  start-page: 113190
  year: 2021
  ident: 10.7717/peerj.12173/ref-40
  article-title: Developing a long-term and powerful in vitro culture and Agrobacterium-mediated transformation system for Miscanthus sinensis (Poaceae)
  publication-title: Industrial Crops and Products
  doi: 10.1016/j.indcrop.2020.113190
– volume: 87
  start-page: 87
  issue: 1
  year: 2016
  ident: 10.7717/peerj.12173/ref-19
  article-title: Extending the biosynthetic repertoires of cyanobacteria and chloroplasts
  publication-title: The Plant Journal
  doi: 10.1111/tpj.13173
– volume: 14
  start-page: 1
  issue: 1
  year: 2013
  ident: 10.7717/peerj.12173/ref-3
  article-title: A detailed gene expression study of the Miscanthus genus reveals changes in the transcriptome associated with the rejuvenation of spring rhizomes
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-14-1
– volume: 19
  start-page: 870
  issue: 9
  year: 2001
  ident: 10.7717/peerj.12173/ref-26
  article-title: Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit
  publication-title: Nature Biotechnology
  doi: 10.1038/nbt0901-870
– volume: 8
  start-page: e80388
  issue: 11
  year: 2013
  ident: 10.7717/peerj.12173/ref-44
  article-title: Molecular insights of genetic variation in Erianthus arundinaceus populations native to China
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0080388
– volume: 49
  start-page: 246
  year: 2007
  ident: 10.7717/peerj.12173/ref-46
  article-title: Comparative analysis of codon usage patterns among mitochondrion, chloroplast and nuclear genes in Triticum aestivum L
  publication-title: Journal of Integrative Plant Biology
  doi: 10.1111/j.1744-7909.2007.00404.x
– volume: 59
  start-page: 149
  issue: 2
  year: 2015
  ident: 10.7717/peerj.12173/ref-23
  article-title: Codon bias as a means to fine-tune gene expression
  publication-title: Molecular Cell
  doi: 10.1016/j.molcel.2015.05.035
– volume: 10
  start-page: 770
  issue: 12
  year: 2014
  ident: 10.7717/peerj.12173/ref-22
  article-title: Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation
  publication-title: Molecular Systems Biology
  doi: 10.15252/msb.20145524
– volume: 24
  start-page: 28
  issue: 1
  year: 1986
  ident: 10.7717/peerj.12173/ref-28
  article-title: An evolutionary perspective on synonymous codon usage in unicellular organisms
  publication-title: Journal of Molecular Evolution
  doi: 10.1007/BF02099948
– volume: 85
  start-page: 2653
  issue: 8
  year: 1988
  ident: 10.7717/peerj.12173/ref-33
  article-title: Directional mutation pressure and neutral molecular evolution
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.85.8.2653
– volume: 20
  start-page: 2886
  issue: 12
  year: 2019
  ident: 10.7717/peerj.12173/ref-42
  article-title: The complete chloroplast genomes of Punica granatum and a comparison with other species in Lythraceae
  publication-title: International Journal of Molecular Sciences
  doi: 10.3390/ijms20122886
– volume: 12
  start-page: 32
  issue: 1
  year: 2011
  ident: 10.7717/peerj.12173/ref-21
  article-title: Synonymous but not the same: the causes and consequences of codon bias
  publication-title: Nature Reviews Genetics
  doi: 10.1038/nrg2899
– volume: 78
  start-page: 343
  issue: 5
  year: 2003
  ident: 10.7717/peerj.12173/ref-11
  article-title: Patterns of codon usage bias in three dicot and four monocot plant species
  publication-title: Genes & Genetic Systems
  doi: 10.1266/ggs.78.343
– volume: 223
  start-page: 1090
  issue: 5
  year: 2006
  ident: 10.7717/peerj.12173/ref-12
  article-title: Enhanced cold tolerance in transgenic tobacco expressing a chloroplast ω-3 fatty acid desaturase gene under the control of a cold-inducible promoter
  publication-title: Planta
  doi: 10.1007/s00425-005-0161-4
– start-page: 295
  volume-title: Genetic improvement of bioenergy crops
  year: 2008
  ident: 10.7717/peerj.12173/ref-37
  article-title: Miscanthus: genetic resources and breeding potential to enhance bioenergy production
  doi: 10.1007/978-0-387-70805-8_10
– volume: 334
  start-page: 80
  year: 2013
  ident: 10.7717/peerj.12173/ref-20
  article-title: Analysis of codon use features of stearoyl-acyl carrier protein desaturase gene in Camellia sinensis
  publication-title: Journal of Theoretical Biology
  doi: 10.1016/j.jtbi.2013.06.006
– volume: 271
  start-page: 101
  issue: 1
  year: 2008
  ident: 10.7717/peerj.12173/ref-24
  article-title: An update on chloroplast genomes
  publication-title: Plant Systematics and Evolution
  doi: 10.1007/s00606-007-0608-0
– volume: 132
  start-page: 300
  issue: 1
  year: 2003
  ident: 10.7717/peerj.12173/ref-9
  article-title: Chloroplast membrane photostability in chlPtransgenic tobacco plants deficient in tocopherols
  publication-title: Plant Physiology
  doi: 10.1104/pp.102.017178
– volume: 35
  start-page: 600
  issue: 6
  year: 2017
  ident: 10.7717/peerj.12173/ref-8
  article-title: Miscanthus sp.: genetic diversity and phylogeny in China
  publication-title: Plant Molecular Biology Reporter
  doi: 10.1007/s11105-017-1048-9
– volume: 14
  start-page: 447
  issue: 5
  year: 2019
  ident: 10.7717/peerj.12173/ref-13
  article-title: Chloroplast-selective gene delivery and expression in planta using chitosan-complexed single-walled carbon nanotube carriers
  publication-title: Nature Nanotechnology
  doi: 10.1038/s41565-019-0375-4
– volume: 8
  start-page: e8251
  year: 2020
  ident: 10.7717/peerj.12173/ref-38
  article-title: Comparative analysis of codon usage patterns in chloroplast genomes of six Euphorbiaceae species
  publication-title: PeerJ
  doi: 10.7717/peerj.8251
– volume: 107
  start-page: 3645
  issue: 8
  year: 2010
  ident: 10.7717/peerj.12173/ref-36
  article-title: Translation efficiency is determined by both codon bias and folding energy
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.0909910107
– volume: 10
  start-page: 1
  issue: 1
  year: 2019
  ident: 10.7717/peerj.12173/ref-2
  article-title: Analysis of codon usage pattern of banana basic secretory protease gene
  publication-title: Plant Diseases and Pests
– volume: 6
  start-page: 1
  issue: 1
  year: 2016
  ident: 10.7717/peerj.12173/ref-30
  article-title: Nuclear DNA content in Miscanthus sp. and the geographical variation pattern in Miscanthus lutarioriparius
  publication-title: Scientific Reports
  doi: 10.1038/s41598-016-0001-8
– volume: 6
  start-page: 646
  issue: 6
  year: 2014
  ident: 10.7717/peerj.12173/ref-4
  article-title: Plant morphology, genome size, and SSR markers differentiate five distinct taxonomic groups among accessions in the genus M iscanthus
  publication-title: GCB Bioenergy
  doi: 10.1111/gcbb.12101
– volume: 7
  start-page: 1
  issue: 1
  year: 2017
  ident: 10.7717/peerj.12173/ref-32
  article-title: Transcriptomics and proteomics reveal genetic and biological basis of superior biomass crop Miscanthus
  publication-title: Scientific Reports
  doi: 10.1038/s41598-016-0028-x
– volume: 60
  start-page: 461
  issue: 5
  year: 2012
  ident: 10.7717/peerj.12173/ref-43
  article-title: Analysis of codon usage patterns of the chloroplast genomes in the Poaceae family
  publication-title: Australian Journal of Botany
  doi: 10.1071/BT12073
– volume: 34
  start-page: 555
  issue: 6
  year: 2007
  ident: 10.7717/peerj.12173/ref-48
  article-title: Analysis of codon usage between different poplar species
  publication-title: Journal of Genetics and Genomics
  doi: 10.1111/j.1744-7909.2007.00404.x
– volume: 14
  start-page: 787
  issue: 12
  year: 2013
  ident: 10.7717/peerj.12173/ref-10
  article-title: Biogenesis and homeostasis of chloroplasts and other plastids
  publication-title: Nature Reviews Molecular Cell Biology
  doi: 10.1038/nrm3702
– volume: 238
  start-page: 53
  issue: 1
  year: 1999
  ident: 10.7717/peerj.12173/ref-35
  article-title: Translation-coupled violation of Parity Rule 2 in human genes is not the cause of heterogeneity of the DNA G+ C content of third codon position
  publication-title: Gene
  doi: 10.1016/S0378-1119(99)00320-0
– volume: 13
  start-page: e0196069
  issue: 4
  year: 2018
  ident: 10.7717/peerj.12173/ref-1
  article-title: The chloroplast genome sequence of bittersweet (Solanum dulcamara): plastid genome structure evolution in Solanaceae
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0196069
– volume: 167
  start-page: 101
  issue: 1
  year: 2004
  ident: 10.7717/peerj.12173/ref-14
  article-title: Synonymous codon usage bias in Oryza sativa
  publication-title: Plant Science
  doi: 10.1016/j.plantsci.2004.03.003
– volume: 66
  start-page: 4213
  issue: 14
  year: 2015
  ident: 10.7717/peerj.12173/ref-7
  article-title: Genetic structure of Miscanthus sinensis and Miscanthus sacchariflorus in Japan indicates a gradient of bidirectional but asymmetric introgression
  publication-title: Journal of Experimental Botany
  doi: 10.1093/jxb/eru511
– volume: 21
  start-page: 835
  issue: 4
  year: 1993
  ident: 10.7717/peerj.12173/ref-29
  article-title: Codon usage: mutational bias, translational selection, or both?
  publication-title: Biochemical Society Transactions
  doi: 10.1042/bst0210835
– volume: 30
  start-page: 335
  issue: 4
  year: 2003
  ident: 10.7717/peerj.12173/ref-16
  article-title: Synonymous codon usage bias in the rice cultivar 93-11 (Oryza sativa L. ssp. indica)
  publication-title: Yi chuan xue bao = Acta genetica Sinica
– volume: 19
  start-page: 3142
  issue: 10
  year: 2018
  ident: 10.7717/peerj.12173/ref-45
  article-title: Differences in codon usage bias between photosynthesis-related genes and genetic system-related genes of chloroplast genomes in cultivated and wild solanum species
  publication-title: International Journal of Molecular Sciences
  doi: 10.3390/ijms19103142
– volume: 2017
  start-page: e3820
  issue: 5
  year: 2017
  ident: 10.7717/peerj.12173/ref-5
  article-title: The complete chloroplast genome of Cinnamomum camphora and its comparison with related Lauraceae species
  publication-title: PeerJ
  doi: 10.7717/peerj.3820
– volume: 17
  start-page: 477
  issue: 2
  year: 1989
  ident: 10.7717/peerj.12173/ref-18
  article-title: Codon usage in plant genes
  publication-title: Nucleic Acids Research
  doi: 10.1093/nar/17.2.477
– volume: 87
  start-page: 23
  issue: 1
  year: 1990
  ident: 10.7717/peerj.12173/ref-39
  article-title: The ‘effective number of codons’ used in a gene
  publication-title: Gene
  doi: 10.1016/0378-1119(90)90491-9
– volume: 37
  start-page: 677
  issue: 2
  year: 2010
  ident: 10.7717/peerj.12173/ref-15
  article-title: Analysis of synonymous codon usage in Zea mays
  publication-title: Molecular Biology Reports
  doi: 10.1007/s11033-009-9521-7
– volume: 40
  start-page: 318
  issue: 3
  year: 1995
  ident: 10.7717/peerj.12173/ref-34
  article-title: Intrastrand parity rules of DNA base composition and usage biases of synonymous codons
  publication-title: Journal of Molecular Evolution
  doi: 10.1007/BF00163236
– volume: 5
  start-page: e3919
  year: 2017
  ident: 10.7717/peerj.12173/ref-6
  article-title: The complete chloroplast genome sequence of strawberry (Fragaria × ananassa Duch.) and comparison with related species of Rosaceae
  publication-title: PeerJ
  doi: 10.7717/peerj.3919
– volume: 162
  start-page: 113248
  year: 2021
  ident: 10.7717/peerj.12173/ref-31
  article-title: The complete chloroplast genome sequences of five Miscanthus species, and comparative analyses with other grass plastomes
  publication-title: Industrial Crops and Products
  doi: 10.1016/j.indcrop.2021.113248
– volume: 10
  start-page: e0129223
  issue: 6
  year: 2015
  ident: 10.7717/peerj.12173/ref-41
  article-title: Comparative analysis of codon usage bias patterns in microsporidian genomes
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0129223
– volume: 19
  start-page: 293
  issue: 4
  year: 2008
  ident: 10.7717/peerj.12173/ref-47
  article-title: Analysis of synonymous codon usage in chloroplast genome of Populus alba
  publication-title: Journal of Forestry Research
  doi: 10.1007/s11676-008-0052-1
– volume: 84
  start-page: 55
  issue: 1
  year: 2005
  ident: 10.7717/peerj.12173/ref-17
  article-title: Comparative studies on codon usage pattern of chloroplasts and their host nuclear genes in four plant species
  publication-title: Journal of Genetics
  doi: 10.1007/BF02715890
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Snippet Miscanthus is not only a perennial fiber biomass crop, but also valuable breeding resource for its low-nutrient requirements, photosynthetic efficiency and...
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StartPage e12173
SubjectTerms Adaptability
Agricultural Science
Amino acids
Analysis
Arabidopsis thaliana
Bioinformatics
Chloroplast genome
Chloroplasts
Codon
Codon optimization
Codon usage pattern
Codons
Comparative analysis
Efficiency
Evolution & development
Flowers & plants
Gene expression
Genes
Genetic engineering
Genetically altered foods
Genomes
Genomics
Miscanthus
Miscanthus species
Molecular Biology
Nutrient requirements
Photosynthesis
Plant breeding
Plant Science
Sorghum
Species
Use statistics
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Title Comparative analysis of codon usage patterns in chloroplast genomes of five Miscanthus species and related species
URI https://www.proquest.com/docview/2575737241
https://www.proquest.com/docview/2580947091
https://pubmed.ncbi.nlm.nih.gov/PMC8466072
https://doaj.org/article/ceb325c07bd348619700b4a93acf2e87
Volume 9
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