Ribosome and Translational Control in Stem Cells

Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic...

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Published inCells (Basel, Switzerland) Vol. 9; no. 2; p. 497
Main Authors Gabut, Mathieu, Bourdelais, Fleur, Durand, Sébastien
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 21.02.2020
MDPI AG
Subjects
Adult Stem Cells - metabolism
Animals
Cell Differentiation
Embryonic Stem Cells - metabolism
Homeostasis
Humans
Life Sciences
Mice
Protein Biosynthesis
Review
ribosomal proteins
Ribosomal Proteins - metabolism
ribosome biogenesis
ribosomes
Ribosomes - metabolism
RNA Processing, Post-Transcriptional
RNA, Messenger - metabolism
RNA, Ribosomal - metabolism
rrna modifications
specialized ribosomes
stem cells
translational regulation
ribosomal proteins
ribosomes
stem cells
rRNA modifications
specialized ribosomes
translational regulation
ribosome biogenesis
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Abstract Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic programs, which are dynamically orchestrated at different steps of gene expression, including chromatin remodeling, mRNA transcription, processing, and stability. In addition to maintaining stem cell homeostasis, these molecular processes need to be rapidly rewired to coordinate complex physiological modifications required to redirect cell fate in response to environmental clues, such as differentiation signals or tissue injuries. Although chromatin remodeling and mRNA expression have been extensively studied in stem cells, accumulating evidence suggests that stem cell transcriptomes and proteomes are poorly correlated and that stem cell properties require finely tuned protein synthesis. In addition, many studies have shown that the biogenesis of the translation machinery, the ribosome, is decisive for sustaining ESC and ASC properties. Therefore, these observations emphasize the importance of translational control in stem cell homeostasis and fate decisions. In this review, we will provide the most recent literature describing how ribosome biogenesis and translational control regulate stem cell functions and are crucial for accommodating proteome remodeling in response to changes in stem cell fate.
AbstractList Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic programs, which are dynamically orchestrated at different steps of gene expression, including chromatin remodeling, mRNA transcription, processing, and stability. In addition to maintaining stem cell homeostasis, these molecular processes need to be rapidly rewired to coordinate complex physiological modifications required to redirect cell fate in response to environmental clues, such as differentiation signals or tissue injuries. Although chromatin remodeling and mRNA expression have been extensively studied in stem cells, accumulating evidence suggests that stem cell transcriptomes and proteomes are poorly correlated and that stem cell properties require finely tuned protein synthesis. In addition, many studies have shown that the biogenesis of the translation machinery, the ribosome, is decisive for sustaining ESC and ASC properties. Therefore, these observations emphasize the importance of translational control in stem cell homeostasis and fate decisions. In this review, we will provide the most recent literature describing how ribosome biogenesis and translational control regulate stem cell functions and are crucial for accommodating proteome remodeling in response to changes in stem cell fate.
Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic programs, which are dynamically orchestrated at different steps of gene expression, including chromatin remodeling, mRNA transcription, processing, and stability. In addition to maintaining stem cell homeostasis, these molecular processes need to be rapidly rewired to coordinate complex physiological modifications required to redirect cell fate in response to environmental clues, such as differentiation signals or tissue injuries. Although chromatin remodeling and mRNA expression have been extensively studied in stem cells, accumulating evidence suggests that stem cell transcriptomes and proteomes are poorly correlated and that stem cell properties require finely tuned protein synthesis. In addition, many studies have shown that the biogenesis of the translation machinery, the ribosome, is decisive for sustaining ESC and ASC properties. Therefore, these observations emphasize the importance of translational control in stem cell homeostasis and fate decisions. In this review, we will provide the most recent literature describing how ribosome biogenesis and translational control regulate stem cell functions and are crucial for accommodating proteome remodeling in response to changes in stem cell fate.Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple progenies in the context of a rapidly developing embryo or in steady-state tissues, respectively. This ability is controlled by complex genetic programs, which are dynamically orchestrated at different steps of gene expression, including chromatin remodeling, mRNA transcription, processing, and stability. In addition to maintaining stem cell homeostasis, these molecular processes need to be rapidly rewired to coordinate complex physiological modifications required to redirect cell fate in response to environmental clues, such as differentiation signals or tissue injuries. Although chromatin remodeling and mRNA expression have been extensively studied in stem cells, accumulating evidence suggests that stem cell transcriptomes and proteomes are poorly correlated and that stem cell properties require finely tuned protein synthesis. In addition, many studies have shown that the biogenesis of the translation machinery, the ribosome, is decisive for sustaining ESC and ASC properties. Therefore, these observations emphasize the importance of translational control in stem cell homeostasis and fate decisions. In this review, we will provide the most recent literature describing how ribosome biogenesis and translational control regulate stem cell functions and are crucial for accommodating proteome remodeling in response to changes in stem cell fate.
Author Durand, Sébastien
Bourdelais, Fleur
Gabut, Mathieu
AuthorAffiliation 2 Université Claude Bernard Lyon 1, 69100 Villeurbanne, France
1 Equipe ‘Transcriptome Diversity in Stem Cells’, Cancer Cell Plasticity Department, INSERM 1052, CNRS 5286, Cancer Research Center of Lyon, Centre Léon Bérard, 69008 Lyon, France fleur.bourdelais@gmail.com (F.B.)
AuthorAffiliation_xml – name: 1 Equipe ‘Transcriptome Diversity in Stem Cells’, Cancer Cell Plasticity Department, INSERM 1052, CNRS 5286, Cancer Research Center of Lyon, Centre Léon Bérard, 69008 Lyon, France fleur.bourdelais@gmail.com (F.B.)
– name: 2 Université Claude Bernard Lyon 1, 69100 Villeurbanne, France
Author_xml – sequence: 1
  givenname: Mathieu
  orcidid: 0000-0001-7343-5361
  surname: Gabut
  fullname: Gabut, Mathieu
– sequence: 2
  givenname: Fleur
  orcidid: 0000-0001-7394-8714
  surname: Bourdelais
  fullname: Bourdelais, Fleur
– sequence: 3
  givenname: Sébastien
  orcidid: 0000-0002-9960-9099
  surname: Durand
  fullname: Durand, Sébastien
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Issue 2
Keywords ribosomal proteins
ribosomes
stem cells
rRNA modifications
specialized ribosomes
translational regulation
ribosome biogenesis
Language English
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Snippet Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity to self-renew while remaining poised to differentiate into multiple...
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StartPage 497
SubjectTerms Adult Stem Cells - metabolism
Animals
Cell Differentiation
Embryonic Stem Cells - metabolism
Homeostasis
Humans
Life Sciences
Mice
Protein Biosynthesis
Review
ribosomal proteins
Ribosomal Proteins - metabolism
ribosome biogenesis
ribosomes
Ribosomes - metabolism
RNA Processing, Post-Transcriptional
RNA, Messenger - metabolism
RNA, Ribosomal - metabolism
rrna modifications
specialized ribosomes
stem cells
translational regulation
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Title Ribosome and Translational Control in Stem Cells
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