Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates - Lyon, Robert P; Setter, Jocelyn R; Bovee, Tim D; Doronina, Svetlana O; Hunter, Joshua H; Anderson, Martha E; Balasubramanian, Cindy L; Duniho, Steven M; Leiske, Chris I; Li, Fu; Senter, Peter D (Nature biotechnology, 2014)
Keywords: 631/154/152; 692/699/67/1059/602; 82/1; Acids; Agriculture; Animals; Antibodies - chemistry; Antibody-drug conjugates; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Bioinformatics; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Catalysis; Cell Proliferation - drug effects; Drug therapy; Excipients - chemistry; Female; Humans; Hydrogen-Ion Concentration; Hydrolysis; Immunoconjugates - chemistry; Immunoconjugates - pharmacology; letter; Life Sciences; Maleimides - chemistry; Mice; Mice, SCID; Monoclonal antibodies; Pharmacology; Pharmacology, Experimental; Plasma; Tumors; Xenograft Model Antitumor Assays