Study on the Sampling of Methadone from Exhaled Breath

• Published in: Journal of analytical toxicology Vol. 35; no. 5; pp. 257 - 263
• Main Authors: Beck, Olof, Sandqvist, Sören, Böttcher, Michael, Eriksen, Paul, Franck, Johan, Palmskog, Göran
• Format: Journal Article
• Language: English
• Published: Niles, IL Oxford University Press 01.06.2011; Preston Publications
• Subjects: Adult; Analysis; Biological and medical sciences; Breath Tests - instrumentation; Breath Tests - methods; Contamination; Drug abuse; Drug addictions; Exhalation; Female; Fibers; Filters; General pharmacology; Humans; Male; Mass spectroscopy; Medical sciences; Medicin och hälsovetenskap; Methadone; Methadone - analysis; Methadone - chemistry; Middle Aged; Mouth; Narcotics - analysis; Narcotics - chemistry; Pharmacology. Drug treatments; Pressure; Saliva; Saliva - chemistry; Sampling; Solid Phase Extraction; Solid phase methods; Substance Abuse Detection - methods; Toxicology; Human; Expired air; Drug addiction; Tandem mass spectrometry; Chemical analysis; Coupled method; HPLC chromatography; Opiates; Patient; Methadone; Narcotic analgesic; Electrospray; Therapeutic drug monitoring; Reversed phase chromatography; Sampling; Quantitative analysis

This study aimed at develop and validate the procedure for collecting exhaled breath for drug testing. Patients receiving methadone maintenance treatment were recruited for the study. Methadone levels were measured using liquid chromatography-electrospray-tandem mass spectrometry. The sampling devic...