Differences In Hepatic Expression of Iron, Inflammation and Stress-Related Genes in Patients with Nonalcoholic Steatohepatitis

• Published in: Annals of hepatology Vol. 16; no. 1; pp. 77 - 85
• Main Authors: Handa, Priya, Maliken, Bryan D., Nelson, James E., Hennessey, Kelly A., Akhila Vemulakonda, L., Morgan-Stevenson, Vicki, Dhillon, Barjinder K., Gupta, Rohit, Yeh, Matthew M., Kowdley, Kris V.
• Format: Journal Article
• Language: English
• Published: Mexico Elsevier España, S.L.U 01.01.2017; Asociación Mexicana de Hepatología, A.C; Elsevier
• Subjects: Adult; Female; Gastroenterology & Hepatology; Gastroenterology and Hepatology; Gene Expression Regulation; Hepcidin; Hepcidins - genetics; Humans; Inflammation; Inflammation - blood; Inflammation - diagnosis; Inflammation - genetics; Inflammation Mediators - blood; Interleukin-1beta - blood; Interleukin-1beta - genetics; Iron; Iron - analysis; Iron Overload - blood; Iron Overload - diagnosis; Iron Overload - genetics; Liver - chemistry; Liver - pathology; Male; Membrane Proteins - genetics; Middle Aged; Non-alcoholic Fatty Liver Disease - blood; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - genetics; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Oxidative Stress - genetics; Real-Time Polymerase Chain Reaction; Serine Endopeptidases - genetics; STAT3 Transcription Factor - genetics; TMPRSS6; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - genetics; Nonalcoholic fatty liver disease; Iron; Inflammation; Nonalcoholic steatohepatitis; TMPRSS6; Hepcidin

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. We have previously shown that hepatic reticuloendothelial system (RES) iron deposition is associated with an advanced degree of nonalcoholic steatohepatitis (NASH) in humans. In this study, we aimed...