Microfluidic Synthesis of Magnetite Nanoparticles for the Controlled Release of Antibiotics

Magnetite nanoparticles (MNPs) have been intensively studied for biomedical applications, especially as drug delivery systems for the treatment of infections. Additionally, they are characterized by intrinsic antimicrobial properties owing to their capacity to disrupt or penetrate the microbial cell...

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Published inPharmaceutics Vol. 15; no. 9; p. 2215
Main Authors Chircov, Cristina, Dumitru, Iulia Alexandra, Vasile, Bogdan Stefan, Oprea, Ovidiu-Cristian, Holban, Alina Maria, Popescu, Roxana Cristina
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 27.08.2023
MDPI
Subjects
Analysis
Antibiotics
Antimicrobial agents
Cell death
Drug delivery systems
Drugs
Fibroblasts
Health aspects
Investigations
Magnetite
magnetite nanoparticles
Mercury cadmium telluride detectors
microfluidics
Nanoparticles
Neomycin
Nosocomial infections
Particle size
Radiation
Software
Spectrum analysis
Vehicles
Germany
Romania
United States > US
Netherlands
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Abstract Magnetite nanoparticles (MNPs) have been intensively studied for biomedical applications, especially as drug delivery systems for the treatment of infections. Additionally, they are characterized by intrinsic antimicrobial properties owing to their capacity to disrupt or penetrate the microbial cell wall and induce cell death. However, the current focus has shifted towards increasing the control of the synthesis reaction to ensure more uniform nanoparticle sizes and shapes. In this context, microfluidics has emerged as a potential candidate method for the controlled synthesis of nanoparticles. Thus, the aim of the present study was to obtain a series of antibiotic-loaded MNPs through a microfluidic device. The structural properties of the nanoparticles were investigated through X-ray diffraction (XRD) and, selected area electron diffraction (SAED), the morphology was evaluated through transmission electron microscopy (TEM) and high-resolution TEM (HR-TEM), the antibiotic loading was assessed through Fourier-transform infrared spectroscopy (FT-IR) and, and thermogravimetry and differential scanning calorimetry (TG-DSC) analyses, and. the release profiles of both antibiotics was determined through UV-Vis spectroscopy. The biocompatibility of the nanoparticles was assessed through the MTT assay on a BJ cell line, while the antimicrobial properties were investigated against the S. aureus, P. aeruginosa, and C. albicans strains. Results proved considerable uniformity of the antibiotic-containing nanoparticles, good biocompatibility, and promising antimicrobial activity. Therefore, this study represents a step forward towards the microfluidic development of highly effective nanostructured systems for antimicrobial therapies.
AbstractList Magnetite nanoparticles (MNPs) have been intensively studied for biomedical applications, especially as drug delivery systems for the treatment of infections. Additionally, they are characterized by intrinsic antimicrobial properties owing to their capacity to disrupt or penetrate the microbial cell wall and induce cell death. However, the current focus has shifted towards increasing the control of the synthesis reaction to ensure more uniform nanoparticle sizes and shapes. In this context, microfluidics has emerged as a potential candidate method for the controlled synthesis of nanoparticles. Thus, the aim of the present study was to obtain a series of antibiotic-loaded MNPs through a microfluidic device. The structural properties of the nanoparticles were investigated through X-ray diffraction (XRD) and, selected area electron diffraction (SAED), the morphology was evaluated through transmission electron microscopy (TEM) and high-resolution TEM (HR-TEM), the antibiotic loading was assessed through Fourier-transform infrared spectroscopy (FT-IR) and, and thermogravimetry and differential scanning calorimetry (TG-DSC) analyses, and. the release profiles of both antibiotics was determined through UV-Vis spectroscopy. The biocompatibility of the nanoparticles was assessed through the MTT assay on a BJ cell line, while the antimicrobial properties were investigated against the S. aureus , P. aeruginosa , and C. albicans strains. Results proved considerable uniformity of the antibiotic-containing nanoparticles, good biocompatibility, and promising antimicrobial activity. Therefore, this study represents a step forward towards the microfluidic development of highly effective nanostructured systems for antimicrobial therapies.
Magnetite nanoparticles (MNPs) have been intensively studied for biomedical applications, especially as drug delivery systems for the treatment of infections. Additionally, they are characterized by intrinsic antimicrobial properties owing to their capacity to disrupt or penetrate the microbial cell wall and induce cell death. However, the current focus has shifted towards increasing the control of the synthesis reaction to ensure more uniform nanoparticle sizes and shapes. In this context, microfluidics has emerged as a potential candidate method for the controlled synthesis of nanoparticles. Thus, the aim of the present study was to obtain a series of antibiotic-loaded MNPs through a microfluidic device. The structural properties of the nanoparticles were investigated through X-ray diffraction (XRD) and, selected area electron diffraction (SAED), the morphology was evaluated through transmission electron microscopy (TEM) and high-resolution TEM (HR-TEM), the antibiotic loading was assessed through Fourier-transform infrared spectroscopy (FT-IR) and, and thermogravimetry and differential scanning calorimetry (TG-DSC) analyses, and. the release profiles of both antibiotics was determined through UV-Vis spectroscopy. The biocompatibility of the nanoparticles was assessed through the MTT assay on a BJ cell line, while the antimicrobial properties were investigated against the S. aureus, P. aeruginosa, and C. albicans strains. Results proved considerable uniformity of the antibiotic-containing nanoparticles, good biocompatibility, and promising antimicrobial activity. Therefore, this study represents a step forward towards the microfluidic development of highly effective nanostructured systems for antimicrobial therapies.
Audience Academic
Author Holban, Alina Maria
Chircov, Cristina
Popescu, Roxana Cristina
Oprea, Ovidiu-Cristian
Vasile, Bogdan Stefan
Dumitru, Iulia Alexandra
AuthorAffiliation 1 Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania; cristina.chircov@yahoo.com
2 National Research Center for Micro and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania; bogdan.vasile@upb.ro (B.S.V.); ovidiu.oprea@upb.ro (O.-C.O.)
6 Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, National University of Science and Technology Politehnica Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania
4 Research Center for Advanced Materials, Products and Processes, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania
8 Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania
3 Faculty of Engineering in Foreign Languages, National University of Science and Technolo
AuthorAffiliation_xml – name: 9 Department of Life and Environmental Science, National Institute for R&D in Physics and Nuclear Engineering Horia Hulubei, 30 Reactorului, 077125 Magurele, Romania
– name: 4 Research Center for Advanced Materials, Products and Processes, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania
– name: 8 Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania
– name: 3 Faculty of Engineering in Foreign Languages, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania; iulia.dumitru2212@stud.fim.upb.ro
– name: 5 National Research Center for Food Safety, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania
– name: 1 Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania; cristina.chircov@yahoo.com
– name: 2 National Research Center for Micro and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania; bogdan.vasile@upb.ro (B.S.V.); ovidiu.oprea@upb.ro (O.-C.O.)
– name: 6 Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, National University of Science and Technology Politehnica Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania
– name: 7 Microbiology and Immunology Department, Faculty of Biology, Research Institute of the University of Bucharest, University of Bucharest, 060101 Bucharest, Romania; alina_m_h@yahoo.com
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CitedBy_id crossref_primary_10_3390_ijms25010246
crossref_primary_10_3390_nano14110902
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Cites_doi 10.3390/magnetochemistry6040068
10.3390/nano12183160
10.3390/ma12132158
10.1016/j.apsb.2023.01.018
10.3390/nano11020360
10.3390/nano12111855
10.3390/nano11040864
10.3390/pharmaceutics14051057
10.1016/j.matchemphys.2021.125384
10.3389/fmolb.2021.677547
10.1179/2047773215Y.0000000030
10.3390/nano12203598
10.3390/ma14195906
10.3390/pharmaceutics11110601
10.3390/molecules26082189
10.1016/j.jcis.2021.03.035
10.1039/D0RA02470H
10.1007/s10967-006-0346-8
10.3390/antibiotics11050623
10.1039/C5RA17729D
10.3390/pharmaceutics14122620
10.3390/ma15072601
10.3390/pharmaceutics14112292
10.1016/j.mtadv.2022.100205
10.1371/journal.pone.0274248
10.3390/ma14071612
10.3390/ijms21197355
10.1016/S0076-6879(09)65007-2
10.1016/j.matpr.2019.02.166
10.1021/acs.analchem.8b02374
10.1038/s41598-017-05184-5
10.1007/s10965-023-03468-1
10.3390/antibiotics11030412
10.1002/adma.201904106
10.1016/j.compositesb.2018.12.075
10.1016/j.apsadv.2021.100163
10.3390/molecules28135198
10.1002/smll.202106580
10.1016/j.ajic.2020.01.009
10.3390/catal12040446
10.1002/anie.200462551
10.1186/s12951-018-0339-0
10.3390/antibiotics11020200
10.1049/mnl.2014.0344
10.1039/b719436f
10.1046/j.1469-0691.2000.00142.x
10.3390/antibiotics10091138
10.3390/ma14051153
10.3390/ijms22094595
10.1186/s40201-016-0262-y
10.1038/s41598-019-51065-4
10.3390/ma6125549
10.3390/polym13050724
10.3390/ijms24076249
10.1088/1468-6996/16/2/023501
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References ref_14
Kakavandi (ref_31) 2016; 14
ref_13
ref_12
Zhang (ref_36) 2023; 13
Mascolo (ref_49) 2013; 6
Zhang (ref_48) 2006; 270
ref_19
ref_18
ref_17
ref_16
Xu (ref_55) 2017; 7
ref_15
Mukhopadhyay (ref_44) 2015; 5
Damiati (ref_54) 2021; 8
Deng (ref_24) 2005; 44
Chellappa (ref_30) 2019; 9
ref_23
ref_22
Koyuncu (ref_35) 2020; 10
Cao (ref_26) 2008; 32
Sun (ref_25) 2015; 10
ref_29
Liu (ref_39) 2022; 18
ref_28
ref_27
Abdullah (ref_20) 2019; 162
Despotovic (ref_5) 2020; 48
Yu (ref_34) 2009; Volume 465
ref_33
ref_32
Ficai (ref_45) 2011; 6
Bendre (ref_37) 2022; 13
Bemetz (ref_51) 2018; 90
Miyazaki (ref_11) 2021; 6
ref_38
Wang (ref_10) 2020; 32
ref_47
ref_46
ref_43
ref_42
ref_41
Wu (ref_21) 2015; 16
ref_40
Baby (ref_52) 2021; 594
Prestinaci (ref_1) 2015; 109
ref_3
ref_2
Elsana (ref_53) 2019; 9
Zou (ref_50) 2022; 276
Zamani (ref_57) 2023; 30
ref_9
ref_8
Gdowski (ref_56) 2018; 16
ref_4
ref_7
ref_6
References_xml – ident: ref_22
  doi: 10.3390/magnetochemistry6040068
– ident: ref_33
  doi: 10.3390/nano12183160
– ident: ref_17
  doi: 10.3390/ma12132158
– volume: 13
  start-page: 3277
  year: 2023
  ident: ref_36
  article-title: Microfluidics for nano-drug delivery systems: From fundamentals to industrialization
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2023.01.018
  contributor:
    fullname: Zhang
– ident: ref_27
  doi: 10.3390/nano11020360
– ident: ref_8
  doi: 10.3390/nano12111855
– ident: ref_38
  doi: 10.3390/nano11040864
– ident: ref_13
  doi: 10.3390/pharmaceutics14051057
– volume: 276
  start-page: 125384
  year: 2022
  ident: ref_50
  article-title: Microfluidic synthesis of magnetic nanoparticles in droplet-based microreactors
  publication-title: Mater. Chem. Phys.
  doi: 10.1016/j.matchemphys.2021.125384
  contributor:
    fullname: Zou
– volume: 8
  start-page: 67754
  year: 2021
  ident: ref_54
  article-title: Microfluidic synthesis of indomethacin-loaded plga microparticles optimized by machine learning
  publication-title: Front. Mol. Biosci.
  doi: 10.3389/fmolb.2021.677547
  contributor:
    fullname: Damiati
– volume: 109
  start-page: 309
  year: 2015
  ident: ref_1
  article-title: Antimicrobial resistance: A global multifaceted phenomenon
  publication-title: Pathog. Glob. Health
  doi: 10.1179/2047773215Y.0000000030
  contributor:
    fullname: Prestinaci
– ident: ref_16
  doi: 10.3390/nano12203598
– ident: ref_32
  doi: 10.3390/ma14195906
– ident: ref_19
  doi: 10.3390/pharmaceutics11110601
– ident: ref_23
– ident: ref_46
  doi: 10.3390/molecules26082189
– volume: 594
  start-page: 474
  year: 2021
  ident: ref_52
  article-title: Microfluidic synthesis of curcumin loaded polymer nanoparticles with tunable drug loading and ph-triggered release
  publication-title: J. Colloid Interface Sci.
  doi: 10.1016/j.jcis.2021.03.035
  contributor:
    fullname: Baby
– volume: 10
  start-page: 15179
  year: 2020
  ident: ref_35
  article-title: Influence of channel height on mixing efficiency and synthesis of iron oxide nanoparticles using droplet-based microfluidics
  publication-title: RSC Adv.
  doi: 10.1039/D0RA02470H
  contributor:
    fullname: Koyuncu
– volume: 270
  start-page: 285
  year: 2006
  ident: ref_48
  article-title: Influence of precipitator agents naoh and NH4OH on the preparation of Fe3O4 nano-particles synthesized by electron beam irradiation
  publication-title: J. Radioanal. Nucl. Chem.
  doi: 10.1007/s10967-006-0346-8
  contributor:
    fullname: Zhang
– ident: ref_41
  doi: 10.3390/antibiotics11050623
– volume: 5
  start-page: 93995
  year: 2015
  ident: ref_44
  article-title: Chitosan-graft-pamam–alginate core–shell nanoparticles: A safe and promising oral insulin carrier in an animal model
  publication-title: RSC Adv.
  doi: 10.1039/C5RA17729D
  contributor:
    fullname: Mukhopadhyay
– ident: ref_14
  doi: 10.3390/pharmaceutics14122620
– ident: ref_18
  doi: 10.3390/ma15072601
– ident: ref_15
  doi: 10.3390/pharmaceutics14112292
– volume: 13
  start-page: 100205
  year: 2022
  ident: ref_37
  article-title: Recent developments in microfluidic technology for synthesis and toxicity-efficiency studies of biomedical nanomaterials
  publication-title: Mater. Today Adv.
  doi: 10.1016/j.mtadv.2022.100205
  contributor:
    fullname: Bendre
– ident: ref_6
  doi: 10.1371/journal.pone.0274248
– ident: ref_47
  doi: 10.3390/ma14071612
– ident: ref_4
  doi: 10.3390/ijms21197355
– volume: Volume 465
  start-page: 129
  year: 2009
  ident: ref_34
  article-title: Chapter 7—Microfluidic methods for production of liposomes
  publication-title: Methods in Enzymology
  doi: 10.1016/S0076-6879(09)65007-2
  contributor:
    fullname: Yu
– volume: 9
  start-page: 371
  year: 2019
  ident: ref_30
  article-title: Fabrication of Fe3O4-silica core-shell magnetic nano-particles and its characterization for biomedical applications
  publication-title: Mater. Today Proc.
  doi: 10.1016/j.matpr.2019.02.166
  contributor:
    fullname: Chellappa
– volume: 90
  start-page: 9975
  year: 2018
  ident: ref_51
  article-title: Microfluidic-based synthesis of magnetic nanoparticles coupled with miniaturized nmr for online relaxation studies
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.8b02374
  contributor:
    fullname: Bemetz
– volume: 7
  start-page: 4794
  year: 2017
  ident: ref_55
  article-title: Controllable microfluidic production of drug-loaded plga nanoparticles using partially water-miscible mixed solvent microdroplets as a precursor
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-05184-5
  contributor:
    fullname: Xu
– volume: 30
  start-page: 86
  year: 2023
  ident: ref_57
  article-title: Characterization of drug-loaded alginate-chitosan polyelectrolyte nanoparticles synthesized by microfluidics
  publication-title: J. Polym. Res.
  doi: 10.1007/s10965-023-03468-1
  contributor:
    fullname: Zamani
– volume: 6
  start-page: 943
  year: 2011
  ident: ref_45
  article-title: Synthesis of rod-like magnetite by using low magnetic field
  publication-title: Dig. J. Nanomater. Biostructures
  contributor:
    fullname: Ficai
– ident: ref_9
  doi: 10.3390/antibiotics11030412
– volume: 32
  start-page: 1904106
  year: 2020
  ident: ref_10
  article-title: Antibiotic-free antibacterial strategies enabled by nanomaterials: Progress and perspectives
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201904106
  contributor:
    fullname: Wang
– volume: 162
  start-page: 538
  year: 2019
  ident: ref_20
  article-title: Solid matrices for fabrication of magnetic iron oxide nanocomposites: Synthesis, properties, and application for the adsorption of heavy metal ions and dyes
  publication-title: Compos. Part B Eng.
  doi: 10.1016/j.compositesb.2018.12.075
  contributor:
    fullname: Abdullah
– volume: 6
  start-page: 100163
  year: 2021
  ident: ref_11
  article-title: Magnetic nanoparticles in biomedical applications: A review
  publication-title: Appl. Surf. Sci. Adv.
  doi: 10.1016/j.apsadv.2021.100163
  contributor:
    fullname: Miyazaki
– ident: ref_29
  doi: 10.3390/molecules28135198
– volume: 18
  start-page: 2106580
  year: 2022
  ident: ref_39
  article-title: Microfluidic nanoparticles for drug delivery
  publication-title: Small
  doi: 10.1002/smll.202106580
  contributor:
    fullname: Liu
– volume: 48
  start-page: 1211
  year: 2020
  ident: ref_5
  article-title: Hospital-acquired infections in the adult intensive care unit—Epidemiology, antimicrobial resistance patterns, and risk factors for acquisition and mortality
  publication-title: Am. J. Infect. Control
  doi: 10.1016/j.ajic.2020.01.009
  contributor:
    fullname: Despotovic
– ident: ref_43
  doi: 10.3390/catal12040446
– volume: 44
  start-page: 2782
  year: 2005
  ident: ref_24
  article-title: Monodisperse magnetic single-crystal ferrite microspheres
  publication-title: Angew. Chem. Int. Ed.
  doi: 10.1002/anie.200462551
  contributor:
    fullname: Deng
– volume: 16
  start-page: 12
  year: 2018
  ident: ref_56
  article-title: Optimization and scale up of microfluidic nanolipomer production method for preclinical and potential clinical trials
  publication-title: J. Nanobiotechnology
  doi: 10.1186/s12951-018-0339-0
  contributor:
    fullname: Gdowski
– ident: ref_7
  doi: 10.3390/antibiotics11020200
– volume: 10
  start-page: 99
  year: 2015
  ident: ref_25
  article-title: Hydrothermal synthesis of magnetite: Investigation of influence of aging time and mechanism
  publication-title: Micro Nano Lett.
  doi: 10.1049/mnl.2014.0344
  contributor:
    fullname: Sun
– volume: 32
  start-page: 1526
  year: 2008
  ident: ref_26
  article-title: Fe3O4 polyhedral nanoparticles with a high magnetization synthesized in mixed solvent ethylene glycol–water system
  publication-title: New J. Chem.
  doi: 10.1039/b719436f
  contributor:
    fullname: Cao
– ident: ref_42
  doi: 10.1046/j.1469-0691.2000.00142.x
– ident: ref_28
  doi: 10.3390/antibiotics10091138
– ident: ref_40
  doi: 10.3390/ma14051153
– ident: ref_2
  doi: 10.3390/ijms22094595
– volume: 14
  start-page: 21
  year: 2016
  ident: ref_31
  article-title: Silica-coated magnetite nanoparticles core-shell spheres (Fe3O4@SiO2) for natural organic matter removal
  publication-title: J. Environ. Health Sci. Eng.
  doi: 10.1186/s40201-016-0262-y
  contributor:
    fullname: Kakavandi
– volume: 9
  start-page: 15120
  year: 2019
  ident: ref_53
  article-title: Evaluation of novel cationic gene based liposomes with cyclodextrin prepared by thin film hydration and microfluidic systems
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-51065-4
  contributor:
    fullname: Elsana
– volume: 6
  start-page: 5549
  year: 2013
  ident: ref_49
  article-title: Room temperature co-precipitation synthesis of magnetite nanoparticles in a large ph window with different bases
  publication-title: Materials
  doi: 10.3390/ma6125549
  contributor:
    fullname: Mascolo
– ident: ref_3
  doi: 10.3390/polym13050724
– ident: ref_12
  doi: 10.3390/ijms24076249
– volume: 16
  start-page: 023501
  year: 2015
  ident: ref_21
  article-title: Recent progress on magnetic iron oxide nanoparticles: Synthesis, surface functional strategies and biomedical applications
  publication-title: Sci. Technol. Adv. Mater.
  doi: 10.1088/1468-6996/16/2/023501
  contributor:
    fullname: Wu
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Snippet Magnetite nanoparticles (MNPs) have been intensively studied for biomedical applications, especially as drug delivery systems for the treatment of infections....
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SubjectTerms Analysis
Antibiotics
Antimicrobial agents
Cell death
Drug delivery systems
Drugs
Fibroblasts
Health aspects
Investigations
Magnetite
magnetite nanoparticles
Mercury cadmium telluride detectors
microfluidics
Nanoparticles
Neomycin
Nosocomial infections
Particle size
Radiation
Software
Spectrum analysis
Vehicles
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Title Microfluidic Synthesis of Magnetite Nanoparticles for the Controlled Release of Antibiotics
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Volume 15
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