Assessment of genomic alterations in non-syndromic von Hippel-Lindau: Insight from integrating somatic and germline next generation sequencing genomic data

• Published in: Data in brief Vol. 39; p. 107653
• Main Authors: Manning, Danielle K., Shivdasani, Priyanka, Koeller, Diane R., Schwartz, Alison, Rana, Huma Q., Garber, Judy E., Lindeman, Neal I., Ghazani, Arezou A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.12.2021; Elsevier
• Subjects: blood; brain; chromosomes; Data; data collection; DNA; genetic profile; genomics; germ cells; Hemangioblastoma; heterozygosity; Matched tumor-germline data; Next generation sequencing; pathogenicity; patients; Rana; Renal cell carcinoma; retina; spinal cord; tumor suppressor genes; urinary bladder neoplasms; VHL gene; Von Hippel-Lindau; Von Hippel-Lindau; VHL gene; Renal cell carcinoma; Matched tumor-germline data; Next generation sequencing; Hemangioblastoma
• ISSN: 2352-3409; 2352-3409
• DOI: 10.1016/j.dib.2021.107653

Von Hippel-Lindau (VHL) syndrome is a hereditary cancer genetic condition associated with inactivating pathogenic alterations in the VHL tumor suppressor gene located at 3p (short arm of chromosome 3). Classic features of VHL include clear cell renal cell carcinoma, hemangioblastomas of the brain, s...