The Histone Variant H3.3 in Transcriptional Regulation and Human Disease

• Published in: Journal of molecular biology Vol. 429; no. 13; pp. 1934 - 1945
• Main Authors: Shi, Leilei, Wen, Hong, Shi, Xiaobing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 30.06.2017
• Subjects: Chromatin - metabolism; DAXX; DNA; epigenetics; Gene Expression Regulation; H3.3; HIRA; histones; Histones - genetics; Histones - metabolism; human cancer; human diseases; Humans; Mutant Proteins - genetics; Mutant Proteins - metabolism; mutation; neoplasms; Neoplasms - genetics; Neoplasms - pathology; nucleosomes; transcription (genetics); Transcription, Genetic; DAXX; SET; PTM; HGG; GCTB; RNA Pol II; CHD1; PML; H3K36me3; epigenetics; HIRA; H3.3; GBM; ESC; PRC2; human cancer; UBN1; ChIP-seq; non-BS-PG; Fas; ZMYND11; DIPG

Histone proteins wrap around DNA to form nucleosomes, which further compact into the higher-order structure of chromatin. In addition to the canonical histones, there are also variant histones that often have pivotal roles in regulating chromatin dynamics and in the accessibility of the underlying D...