Sanguinarine induces apoptosis in Eimeria tenella sporozoites via the generation of reactive oxygen species

• Published in: Poultry science Vol. 101; no. 5; p. 101771
• Main Authors: Li, Jun-Yi, Huang, Hai-Bin, Pan, Tian-Xu, Wang, Nan, Shi, Chun-Wei, Zhang, Bo, Wang, Chun-Feng, Yang, Gui-Lian
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2022; Elsevier
• Subjects: Animals; Apoptosis; Benzophenanthridines; calcium; Calcium - pharmacology; caspase-3; Chickens; Coccidiosis - drug therapy; Coccidiosis - veterinary; drugs; Eimeria tenella; Eimeria tenella - physiology; flow cytometry; fluorescent antibody technique; IMMUNOLOGY, HEALTH AND DISEASE; Isoquinolines; membrane potential; mitochondrial membrane; oxygen; Poultry Diseases - drug therapy; poultry industry; Reactive Oxygen Species; sanguinarine; sporozoite; sporozoites; Sporozoites - physiology; veterinary medicine; Eimeria tenella; sanguinarine; apoptosis; sporozoite

Eimeria tenella (E. tenella) is the most pathogenic genus in Eimeria and can lead to a huge number of deaths of chickens, causing significant economic losses in the poultry industry worldwide. As a natural alkaloid, sanguinarine has many medicinal effects; to a certain extent, it can replace antibio...