Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation
Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunogl...
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| Published in | Journal of experimental medicine Vol. 198; no. 2; pp. 223 - 233 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Rockefeller University Press
21.07.2003
The Rockefeller University Press |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-1007 1540-9538 |
| DOI | 10.1084/jem.20021825 |
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| Abstract | Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domain and mediates endocytosis of the receptor and inhibition of IgE-mediated degranulation from mast cells. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12 and stimulates proinflammatory cytokines and chemokine secretions from macrophages. Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses. |
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| AbstractList | Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domain and mediates endocytosis of the receptor and inhibition of IgE-mediated degranulation from mast cells. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12 and stimulates proinflammatory cytokines and chemokine secretions from macrophages. Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses. Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domain and mediates endocytosis of the receptor and inhibition of IgE-mediated degranulation from mast cells. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12 and stimulates proinflammatory cytokines and chemokine secretions from macrophages. Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses.Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domain and mediates endocytosis of the receptor and inhibition of IgE-mediated degranulation from mast cells. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12 and stimulates proinflammatory cytokines and chemokine secretions from macrophages. Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses. |
| Author | Nakauchi Hiromitsu 大越 靖 渋谷 和子 Yamazaki Satoshi Iwama Atsushi 渋谷 彰 Okoshi Yasushi Yotsumoto Katsumi 本多 伸一郎 Honda Shin-ichiro 田原 聡子 Tahara-Hanaoka Satoko Osawa Mitsujiro Kuroiwa Asato Matsuda Yoichi Shibuya Kazuko Tenen Daniel G. Shibuya Akira |
| AuthorAffiliation | 1 Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan 3 Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, Tsukuba, Ibaraki 305-8575, Japan 2 Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, Tsukuba, Ibaraki 305-0034, Japan 4 Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tsukuba, Ibaraki 305-8575, Japan 5 Laboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science and Chromosome Research Unit, Faculty of Science, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan 6 Harvard Institute of Medicine, Harvard Medical School, Boston, MA 02115 |
| AuthorAffiliation_xml | – name: 4 Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tsukuba, Ibaraki 305-8575, Japan – name: 1 Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan – name: 5 Laboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science and Chromosome Research Unit, Faculty of Science, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan – name: 2 Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, Tsukuba, Ibaraki 305-0034, Japan – name: 6 Harvard Institute of Medicine, Harvard Medical School, Boston, MA 02115 – name: 3 Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, Tsukuba, Ibaraki 305-8575, Japan |
| Author_xml | – sequence: 1 fullname: 大越 靖 – sequence: 2 fullname: 渋谷 和子 – sequence: 3 fullname: 田原 聡子 – sequence: 4 fullname: 本多 伸一郎 – sequence: 5 fullname: 渋谷 彰 – sequence: 6 fullname: Yotsumoto Katsumi – sequence: 7 fullname: Okoshi Yasushi – sequence: 8 fullname: Shibuya Kazuko – sequence: 9 fullname: Yamazaki Satoshi – sequence: 10 fullname: Tahara-Hanaoka Satoko – sequence: 11 fullname: Honda Shin-ichiro – sequence: 12 fullname: Osawa Mitsujiro – sequence: 13 orcidid: 0000-0002-3942-3372 fullname: Kuroiwa Asato – sequence: 14 fullname: Matsuda Yoichi – sequence: 15 fullname: Tenen Daniel G. – sequence: 16 fullname: Iwama Atsushi – sequence: 17 fullname: Nakauchi Hiromitsu – sequence: 18 fullname: Shibuya Akira |
| BackLink | https://cir.nii.ac.jp/crid/1572824502479130112$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/12874256$$D View this record in MEDLINE/PubMed |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 The present address of M. Osawa, A. Iwama, and H. Nakauchi is the Laboratory of Stem Cell Therapy, Center for Experimental Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, 108-8639 Japan. |
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| SubjectTerms | Amino Acid Sequence Animals Base Sequence Carrier Proteins - genetics Carrier Proteins - immunology Cloning, Molecular DNA Primers DNA, Complementary - genetics Macrophage Activation - immunology Macrophages - immunology Mast Cells - immunology Molecular Sequence Data Protein Isoforms - genetics Protein Isoforms - immunology Rats Receptors, Polymeric Immunoglobulin - genetics Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid Transcription, Genetic Tumor Cells, Cultured |
| Title | Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation |
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