Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation

• Published in: Journal of experimental medicine Vol. 198; no. 2; pp. 223 - 233
• Main Authors: 大越 靖, 渋谷 和子, 田原 聡子, 本多 伸一郎, 渋谷 彰, Yotsumoto Katsumi, Okoshi Yasushi, Shibuya Kazuko, Yamazaki Satoshi, Tahara-Hanaoka Satoko, Honda Shin-ichiro, Osawa Mitsujiro, Kuroiwa Asato, Matsuda Yoichi, Tenen Daniel G., Iwama Atsushi, Nakauchi Hiromitsu, Shibuya Akira
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 21.07.2003; The Rockefeller University Press
• Subjects: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins - genetics; Carrier Proteins - immunology; Cloning, Molecular; DNA Primers; DNA, Complementary - genetics; Macrophage Activation - immunology; Macrophages - immunology; Mast Cells - immunology; Molecular Sequence Data; Protein Isoforms - genetics; Protein Isoforms - immunology; Rats; Receptors, Polymeric Immunoglobulin - genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Transcription, Genetic; Tumor Cells, Cultured
• ISSN: 0022-1007; 1540-9538
• DOI: 10.1084/jem.20021825

Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domain and mediates endocytosis of the receptor and inhibition of IgE-mediated degranulation from mast cells. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12 and stimulates proinflammatory cytokines and chemokine secretions from macrophages. Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses.