B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing

• Published in: Immunity (Cambridge, Mass.) Vol. 55; no. 12; pp. 2336 - 2351.e12
• Main Authors: Frede, Annika, Czarnewski, Paulo, Monasterio, Gustavo, Tripathi, Kumar P., Bejarano, David A., Ramirez Flores, Ricardo O., Sorini, Chiara, Larsson, Ludvig, Luo, Xinxin, Geerlings, Laura, Novella-Rausell, Claudio, Zagami, Chiara, Kuiper, Raoul, Morales, Rodrigo A., Castillo, Francisca, Hunt, Matthew, Mariano, Livia Lacerda, Hu, Yue O.O., Engblom, Camilla, Lennon-Duménil, Ana-Maria, Mittenzwei, Romy, Westendorf, Astrid M., Hövelmeyer, Nadine, Lundeberg, Joakim, Saez-Rodriguez, Julio, Schlitzer, Andreas, Das, Srustidhar, Villablanca, Eduardo J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.12.2022
• Subjects: Animals; B cell; Colitis; Disease Models, Animal; Epithelial Cells - metabolism; Epithelium; fibroblasts; inflammation; Intestinal Mucosa; mucosal healing; organoids; single cell; spatial transcriptomics; stromal cell; tissue repair; Wound Healing; stromal cell; B cell; single cell; fibroblasts; inflammation; spatial transcriptomics; organoids; epithelium; tissue repair; mucosal healing

Therapeutic promotion of intestinal regeneration holds great promise, but defining the cellular mechanisms that influence tissue regeneration remains an unmet challenge. To gain insight into the process of mucosal healing, we longitudinally examined the immune cell composition during intestinal dama...