Discovery of farnesoid X receptor and its role in bile acid metabolism

• Published in: Molecular and cellular endocrinology Vol. 548; p. 111618
• Main Authors: Chiang, John Y.L., Ferrell, Jessica M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.05.2022
• Subjects: adrenal glands; Animals; bile; Bile acid receptors; bile acids; Bile Acids and Salts - metabolism; Cholestasis; cholesterol; diabetes; drugs; endocrinology; energy; energy metabolism; enzymes; farnesol; fatty liver; Fatty liver diseases; FXR; glucose; Glucose - metabolism; homeostasis; intestinal microorganisms; intestines; kidneys; ligands; Lipid Metabolism; Lipids; liver; Liver - metabolism; Metabolic disease; obesity; Rats; Receptors, Cytoplasmic and Nuclear - metabolism; resorption; secretion; FXR; NAFLD; NR; UDCA; CYP7A1; Metabolic disease; PBC; Bile acid receptors; CA; CDCA; PSC; DCA; HCC; MCA; LCA; CYP7B1; NASH; OCA; CYP27A1; TGR5; FGF15; PFIC; FGF19; FGFR4; Fatty liver diseases; Cholestasis

In 1995, the nuclear hormone orphan receptor farnesoid X receptor (FXR, NR1H4) was identified as a farnesol receptor expressed mainly in liver, kidney, and adrenal gland of rats. In 1999, bile acids were identified as endogenous FXR ligands. Subsequently, FXR target genes involved in the regulation...