Chromosomal location targets different MYC family gene members for oncogenic translocations

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 7; pp. 2265 - 2270
• Main Authors: Gostissa, Monica, Ranganath, Sheila, Bianco, Julia M, Alt, Frederick W
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 17.02.2009; National Acad Sciences
• Subjects: Alleles; Animal models; Animals; Apoptosis; Biological Sciences; c-Myc protein; Cancer; Cell culture; Cell growth; Cell proliferation; Cells; Chromosome Aberrations; Chromosome translocation; Chromosome translocations; Chromosomes; Chromosomes - ultrastructure; Coding; Deoxyribonucleic acid; DNA; DNA - metabolism; DNA Ligase ATP; DNA Ligases - genetics; DNA Ligases - metabolism; DNA probes; Enzymes; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes; Genetic loci; Heterozygote; Homozygote; Humans; LIG4 protein; Lymphoma; Malignancy; Mice; myc genes; Myc protein; N-Myc protein; Neuroblastoma; Oncogenes; p53 protein; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Stem cells; Transcription; Transcription activation; Tumor suppressor genes; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumors

The MYC family of cellular oncogenes includes c-Myc, N-myc, and L-myc, which encode transcriptional regulators involved in the control of cell proliferation and death. Accordingly, these genes become aberrantly activated and expressed in specific types of cancers. For example, c-Myc translocations o...