Fluorescent activity-based probe for the selective detection of Factor VII activating protease (FSAP) in human plasma

• Published in: Thrombosis research Vol. 182; pp. 124 - 132
• Main Authors: Rut, Wioletta, Nielsen, Nis Valentin, Czarna, Justyna, Poreba, Marcin, Kanse, Sandip M., Drag, Marcin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.10.2019
• Subjects: Active site; Amino Acids - chemistry; Carbocyanines - chemistry; Enzyme Assays - methods; Fluorescent Dyes - chemistry; FSAP; HABP2; Hematology, Oncology, and Palliative Medicine; Humans; Oligopeptides - chemistry; Probe; Serine Endopeptidases - analysis; Serine Endopeptidases - blood; Serine protease; Substrate Specificity; Serine protease; Probe; FSAP; Active site; HABP2

The zymogen form of circulating Factor VII activating protease (FSAP) is activated by histones that are released as a consequence of tissue damage or excessive inflammation. This is likely to have consequences in a number of disease conditions such as stroke, atherosclerosis, liver fibrosis, thrombo...