Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran

• Published in: British journal of cancer Vol. 111; no. 12; pp. 2235 - 2241
• Main Authors: Roshandel, G, Merat, S, Sotoudeh, M, Khoshnia, M, Poustchi, H, Lao-Sirieix, P, Malhotra, S, O'Donovan, M, Etemadi, A, Nickmanesh, A, Pourshams, A, Norouzi, A, Debiram, I, Semnani, S, Abnet, C C, Dawsey, S M, Fitzgerald, R C, Malekzadeh, R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.12.2014; Nature Publishing Group
• Subjects: 692/699/67/1504/1477; 692/699/67/2322; 692/699/67/2324; Accuracy; Asymptomatic; Biological and medical sciences; Biomarkers; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Carcinoma in Situ - diagnosis; Carcinoma in Situ - pathology; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - pathology; Clinical Study; Cohort analysis; Cohort Studies; Disease; Drug Resistance; Endoscopy; Epidemiology; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma; Esophagus; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Iodine; Iran; Male; Medical research; Medical sciences; Methods; Middle Aged; Molecular Medicine; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Oncology; Pilot Projects; Precancerous Conditions - diagnosis; Precancerous Conditions - pathology; Risk Factors; Tumors; Iran; Asia; screening; oesophageal squamous cell carcinoma; cytological examination; Northern Iran; p53; High risk; Esophageal squamous dysplasia; Esophageal disease; Esophagus squamous cell carcinoma; Cytology; Malignant tumor; Medical screening; Esophagus cancer; Cancerology; TP53 Gene; Digestive diseases; Cell; Cancer; Tumor suppressor gene

Background: Oesophageal squamous cell carcinoma (ESCC) is a fatal disease with 5-year survival rates of <5% in Northern Iran. Oesophageal squamous dysplasia (ESD) is the precursor histologic lesion of ESCC. This pilot study was conducted to assess the feasibility, safety, and acceptability of non...