Composition of the mitochondrial electron transport chain in Acanthamoeba castellanii: Structural and evolutionary insights

• Published in: Biochimica et biophysica acta Vol. 1817; no. 11; pp. 2027 - 2037
• Main Authors: Gawryluk, Ryan M.R., Chisholm, Kenneth A., Pinto, Devanand M., Gray, Michael W.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2012
• Subjects: Acanthamoeba castellanii; Acanthamoeba castellanii - genetics; Acanthamoeba castellanii - metabolism; adenosine triphosphate; Amino Acid Sequence; animals; bacteria; bioinformatics; Computational Biology; electron transfer; Electron Transport; Electron transport chain; Electron Transport Chain Complex Proteins - analysis; Electron Transport Chain Complex Proteins - chemistry; Electron Transport Chain Complex Proteins - physiology; Electron Transport Complex I - analysis; Electron Transport Complex I - chemistry; Electron Transport Complex I - physiology; Electron Transport Complex II - analysis; Electron Transport Complex II - physiology; Electron Transport Complex III - analysis; Electron Transport Complex III - physiology; Electron Transport Complex IV - analysis; Electron Transport Complex IV - physiology; eukaryotic cells; Evolution, Molecular; fungi; Mass spectrometry; mitochondria; Mitochondria - metabolism; Mitochondrion; Molecular Sequence Data; oxidation; phylogeny; plants (botany); polyacrylamide gel electrophoresis; proteins; Proteome; Protist; Mitochondrion; Electron transport chain; Mass spectrometry; Protist

The mitochondrion, derived in evolution from an α-proteobacterial progenitor, plays a key metabolic role in eukaryotes. Mitochondria house the electron transport chain (ETC) that couples oxidation of organic substrates and electron transfer to proton pumping and synthesis of ATP. The ETC comprises s...