Cells derived from iPSC can be immunogenic -- Yes or No

• Published in: Protein & cell Vol. 5; no. 1; pp. 1 - 3
• Main Authors: Cao, Jiani, Li, Xiaoyan, Lu, Xiao, Zhang, Chao, Yu, Honghao, Zhao, Tongbiao
• Format: Journal Article
• Language: English
• Published: Beijing Higher Education Press 2014
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Proteins - metabolism; Cell Transplantation - methods; Developmental Biology; Discussion; Graft Rejection - immunology; Human Genetics; Induced Pluripotent Stem Cells - immunology; Induced Pluripotent Stem Cells - transplantation; iPS; Life Sciences; Membrane Proteins - metabolism; Mice, Knockout; Protein Science; Stem Cells; Teratoma - immunology; Teratoma - metabolism; 体细胞; 免疫原性; 免疫排斥反应; 免疫耐受; 再生医学; 多能干细胞; 细胞分化; Immune Rejection; Pluripotent Stem Cell; Teratoma; Autologous Cell; iPSC

The induced pluripotent stem cells （iPSCs）, derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without...