Cells derived from iPSC can be immunogenic -- Yes or No
The induced pluripotent stem cells （iPSCs）, derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without...
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| Published in | Protein & cell Vol. 5; no. 1; pp. 1 - 3 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Beijing
Higher Education Press
2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The induced pluripotent stem cells （iPSCs）, derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syn- geneic iPSC-derived cells can be immunogenic in syn- geneic hosts by using a teratoma transplantation model （Nature 474：212-215, 2011）. Recently two research groups differentiated the iPSCs into different germ lay- ers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either ＂negli- gible＂ or ＂lack of＂ immunogenicity in iPSC derivatives （Nature 494：100-104, 2013; Cell Stem Cell 12：407-412, 2013）. To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergenUy required for translation of iPSC technology to clinics. |
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| AbstractList | The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syngeneic iPSC-derived cells can be immunogenic in syngeneic hosts by using a teratoma transplantation model (Nature 474:212-215, 2011). Recently two research groups differentiated the iPSCs into different germ layers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either "negligible" or "lack of" immunogenicity in iPSC derivatives (Nature 494:100-104, 2013; Cell Stem Cell 12:407-412, 2013). To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergently required for translation of iPSC technology to clinics.The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syngeneic iPSC-derived cells can be immunogenic in syngeneic hosts by using a teratoma transplantation model (Nature 474:212-215, 2011). Recently two research groups differentiated the iPSCs into different germ layers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either "negligible" or "lack of" immunogenicity in iPSC derivatives (Nature 494:100-104, 2013; Cell Stem Cell 12:407-412, 2013). To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergently required for translation of iPSC technology to clinics. The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syngeneic iPSC-derived cells can be immunogenic in syngeneic hosts by using a teratoma transplantation model (Nature 474:212-215, 2011). Recently two research groups differentiated the iPSCs into different germ layers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either "negligible" or "lack of" immunogenicity in iPSC derivatives (Nature 494:100-104, 2013; Cell Stem Cell 12:407-412, 2013). To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergently required for translation of iPSC technology to clinics. The induced pluripotent stem cells （iPSCs）, derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syn- geneic iPSC-derived cells can be immunogenic in syn- geneic hosts by using a teratoma transplantation model （Nature 474：212-215, 2011）. Recently two research groups differentiated the iPSCs into different germ lay- ers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either ＂negli- gible＂ or ＂lack of＂ immunogenicity in iPSC derivatives （Nature 494：100-104, 2013; Cell Stem Cell 12：407-412, 2013）. To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergenUy required for translation of iPSC technology to clinics. The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syngeneic iPSC-derived cells can be immunogenic in syngeneic hosts by using a teratoma transplantation model (Nature 474:212–215, 2011 ). Recently two research groups differentiated the iPSCs into different germ layers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either “negligible” or “lack of” immunogenicity in iPSC derivatives (Nature 494:100–104, 2013 ; Cell Stem Cell 12:407–412, 2013 ). To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergently required for translation of iPSC technology to clinics. |
| Author | Lu, Xiao Cao, Jiani Yu, Honghao Zhang, Chao Zhao, Tongbiao Li, Xiaoyan |
| AuthorAffiliation | State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China |
| Author_xml | – sequence: 1 givenname: Jiani surname: Cao fullname: Cao, Jiani organization: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 2 givenname: Xiaoyan surname: Li fullname: Li, Xiaoyan organization: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 3 givenname: Xiao surname: Lu fullname: Lu, Xiao organization: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 4 givenname: Chao surname: Zhang fullname: Zhang, Chao organization: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 5 givenname: Honghao surname: Yu fullname: Yu, Honghao organization: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China – sequence: 6 givenname: Tongbiao surname: Zhao fullname: Zhao, Tongbiao email: tbzhao@ioz.ac.cn organization: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24474200$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/ajcp/82.1.115 10.1038/nature09798 10.1634/stemcells.2007-0151 10.1038/ng.471 10.1038/nbt.1667 10.1038/nature10135 10.1016/j.tcb.2009.12.004 10.1038/nature09342 10.1038/nature11807 10.1016/j.stem.2013.01.006 10.1097/00000658-198309000-00016 10.1016/j.cell.2006.07.024 10.1038/nature09805 |
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| Keywords | Immune Rejection Pluripotent Stem Cell Teratoma Autologous Cell iPSC |
| Language | English |
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| Notes | The induced pluripotent stem cells （iPSCs）, derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syn- geneic iPSC-derived cells can be immunogenic in syn- geneic hosts by using a teratoma transplantation model （Nature 474：212-215, 2011）. Recently two research groups differentiated the iPSCs into different germ lay- ers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either ＂negli- gible＂ or ＂lack of＂ immunogenicity in iPSC derivatives （Nature 494：100-104, 2013; Cell Stem Cell 12：407-412, 2013）. To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergenUy required for translation of iPSC technology to clinics. 11-5886/Q ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
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| Snippet | The induced pluripotent stem cells （iPSCs）, derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited... The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited... |
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| SubjectTerms | Animals Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Proteins - metabolism Cell Transplantation - methods Developmental Biology Discussion Graft Rejection - immunology Human Genetics Induced Pluripotent Stem Cells - immunology Induced Pluripotent Stem Cells - transplantation iPS Life Sciences Membrane Proteins - metabolism Mice, Knockout Protein Science Stem Cells Teratoma - immunology Teratoma - metabolism 体细胞 免疫原性 免疫排斥反应 免疫耐受 再生医学 多能干细胞 细胞分化 |
| Title | Cells derived from iPSC can be immunogenic -- Yes or No |
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