Stress-induced enhancement of fear learning: An animal model of posttraumatic stress disorder

• Published in: Neuroscience and biobehavioral reviews Vol. 29; no. 8; pp. 1207 - 1223
• Main Authors: Rau, Vinuta, DeCola, Joseph P., Fanselow, Michael S.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Elsevier Ltd 2005; Elsevier
• Subjects: 2-Amino-5-phosphonovalerate - pharmacology; Adult and adolescent clinical studies; Analysis of Variance; Animal; Animal ethology; Animals; Anxiety disorders. Neuroses; Avoidance Learning - drug effects; Avoidance Learning - physiology; Behavior, Animal; Biological and medical sciences; Conditioning (Psychology) - drug effects; Conditioning (Psychology) - physiology; Disease Models, Animal; Electroshock - adverse effects; Excitatory Amino Acid Antagonists - pharmacology; Extinction, Psychological - drug effects; Extinction, Psychological - physiology; Fear; Fear conditioning; Freezing; Freezing Reaction, Cataleptic - physiology; Freezing Reaction, Cataleptic - radiation effects; Fundamental and applied biological sciences. Psychology; Injections, Intraventricular - methods; Learning; Learning. Memory; Male; Mammalia; Medical sciences; Post-traumatic stress disorder; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; PTSD; Random Allocation; Rats; Rats, Long-Evans; Sensitization; Stress; Stress Disorders, Post-Traumatic - physiopathology; Time Factors; Vertebrata; Learning; PTSD; Sensitization; Freezing; Stress; Fear conditioning; Affect affectivity; Animal model; Posttraumatic syndrome; Rodentia; Anxiety disorder; Rattus norvegicus; Emotion emotionality; Posttraumatic stress disorder; Fear; Vertebrata; Mammalia; Acquisition process; Conditioning

Fear is an adaptive response that initiates defensive behavior to protect animals and humans from danger. However, anxiety disorders, such as Posttraumatic Stress Disorder (PTSD), can occur when fear is inappropriately regulated. Fear conditioning can be used to study aspects of PTSD, and we have de...