Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction
The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown. We sought to characterize subjects with severe asthma with and without chronic persistent airflow obstruction with respect to airway wall remodeling (histopathologic and radiologic)...
Saved in:
| Published in | Journal of allergy and clinical immunology Vol. 124; no. 1; pp. 45 - 51.e4 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Mosby, Inc
01.07.2009
Elsevier Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0091-6749 1097-6825 1097-6825 |
| DOI | 10.1016/j.jaci.2009.03.049 |
Cover
Loading…
| Abstract | The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown.
We sought to characterize subjects with severe asthma with and without chronic persistent airflow obstruction with respect to airway wall remodeling (histopathologic and radiologic) and specific sputum biomarkers.
Subjects with severe asthma with chronic persistent (n = 16) or intermittent (n = 18) obstruction were studied. Endobronchial biopsy specimens were analyzed for airway smooth muscle area, epithelial detachment, basement membrane thickness, and submucosal fibrosis. Levels of eosinophil cationic protein, myeloperoxidase, matrix metalloproteinase 9, tissue inhibitor of matrix metalloproteinase 1 (ELISA), and 27 cytokines (multiplex assay) and differential cell counts were measured in induced sputum. Airway thickness was measured by means of high-resolution computed tomographic scanning.
Chronic persistent obstruction was associated with earlier age of onset, longer disease duration, more inflammatory cells in the sputum, and greater smooth muscle area (15.65% ± 2.69% [n = 10] vs 8.96% ± 1.99% [n = 14],
P = .0325). No differences between groups were found for any of the biomarker molecules measured in sputum individually. However, principal component analysis revealed that the dominant variables in the chronic persistent obstruction group were IL-12, IL-13, and IFN-γ, whereas IL-9, IL-17, monocyte chemotactic protein 1, and RANTES were dominant in the other group. Airway imaging revealed no differences between groups.
Subjects with severe asthma with chronic persistent obstruction have increased airway smooth muscle with ongoing T
H1 and T
H2 inflammatory responses. Neither airway measurements on high-resolution computed tomographic scans nor sputum analysis seem able to identify such patients. |
|---|---|
| AbstractList | The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown.
We sought to characterize subjects with severe asthma with and without chronic persistent airflow obstruction with respect to airway wall remodeling (histopathologic and radiologic) and specific sputum biomarkers.
Subjects with severe asthma with chronic persistent (n = 16) or intermittent (n = 18) obstruction were studied. Endobronchial biopsy specimens were analyzed for airway smooth muscle area, epithelial detachment, basement membrane thickness, and submucosal fibrosis. Levels of eosinophil cationic protein, myeloperoxidase, matrix metalloproteinase 9, tissue inhibitor of matrix metalloproteinase 1 (ELISA), and 27 cytokines (multiplex assay) and differential cell counts were measured in induced sputum. Airway thickness was measured by means of high-resolution computed tomographic scanning.
Chronic persistent obstruction was associated with earlier age of onset, longer disease duration, more inflammatory cells in the sputum, and greater smooth muscle area (15.65% ± 2.69% [n = 10] vs 8.96% ± 1.99% [n = 14],
P = .0325). No differences between groups were found for any of the biomarker molecules measured in sputum individually. However, principal component analysis revealed that the dominant variables in the chronic persistent obstruction group were IL-12, IL-13, and IFN-γ, whereas IL-9, IL-17, monocyte chemotactic protein 1, and RANTES were dominant in the other group. Airway imaging revealed no differences between groups.
Subjects with severe asthma with chronic persistent obstruction have increased airway smooth muscle with ongoing T
H1 and T
H2 inflammatory responses. Neither airway measurements on high-resolution computed tomographic scans nor sputum analysis seem able to identify such patients. Background The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown. Objectives We sought to characterize subjects with severe asthma with and without chronic persistent airflow obstruction with respect to airway wall remodeling (histopathologic and radiologic) and specific sputum biomarkers. Methods Subjects with severe asthma with chronic persistent (n = 16) or intermittent (n = 18) obstruction were studied. Endobronchial biopsy specimens were analyzed for airway smooth muscle area, epithelial detachment, basement membrane thickness, and submucosal fibrosis. Levels of eosinophil cationic protein, myeloperoxidase, matrix metalloproteinase 9, tissue inhibitor of matrix metalloproteinase 1 (ELISA), and 27 cytokines (multiplex assay) and differential cell counts were measured in induced sputum. Airway thickness was measured by means of high-resolution computed tomographic scanning. Results Chronic persistent obstruction was associated with earlier age of onset, longer disease duration, more inflammatory cells in the sputum, and greater smooth muscle area (15.65% ± 2.69% [n = 10] vs 8.96% ± 1.99% [n = 14], P = .0325). No differences between groups were found for any of the biomarker molecules measured in sputum individually. However, principal component analysis revealed that the dominant variables in the chronic persistent obstruction group were IL-12, IL-13, and IFN-γ, whereas IL-9, IL-17, monocyte chemotactic protein 1, and RANTES were dominant in the other group. Airway imaging revealed no differences between groups. Conclusion Subjects with severe asthma with chronic persistent obstruction have increased airway smooth muscle with ongoing TH 1 and TH 2 inflammatory responses. Neither airway measurements on high-resolution computed tomographic scans nor sputum analysis seem able to identify such patients. The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown. We sought to characterize subjects with severe asthma with and without chronic persistent airflow obstruction with respect to airway wall remodeling (histopathologic and radiologic) and specific sputum biomarkers. Subjects with severe asthma with chronic persistent (n = 16) or intermittent (n = 18) obstruction were studied. Endobronchial biopsy specimens were analyzed for airway smooth muscle area, epithelial detachment, basement membrane thickness, and submucosal fibrosis. Levels of eosinophil cationic protein, myeloperoxidase, matrix metalloproteinase 9, tissue inhibitor of matrix metalloproteinase 1 (ELISA), and 27 cytokines (multiplex assay) and differential cell counts were measured in induced sputum. Airway thickness was measured by means of high-resolution computed tomographic scanning. Chronic persistent obstruction was associated with earlier age of onset, longer disease duration, more inflammatory cells in the sputum, and greater smooth muscle area (15.65% +/- 2.69% [n = 10] vs 8.96% +/- 1.99% [n = 14], P = .0325). No differences between groups were found for any of the biomarker molecules measured in sputum individually. However, principal component analysis revealed that the dominant variables in the chronic persistent obstruction group were IL-12, IL-13, and IFN-gamma, whereas IL-9, IL-17, monocyte chemotactic protein 1, and RANTES were dominant in the other group. Airway imaging revealed no differences between groups. Subjects with severe asthma with chronic persistent obstruction have increased airway smooth muscle with ongoing T(H)1 and T(H)2 inflammatory responses. Neither airway measurements on high-resolution computed tomographic scans nor sputum analysis seem able to identify such patients. The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown.BACKGROUNDThe patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown.We sought to characterize subjects with severe asthma with and without chronic persistent airflow obstruction with respect to airway wall remodeling (histopathologic and radiologic) and specific sputum biomarkers.OBJECTIVESWe sought to characterize subjects with severe asthma with and without chronic persistent airflow obstruction with respect to airway wall remodeling (histopathologic and radiologic) and specific sputum biomarkers.Subjects with severe asthma with chronic persistent (n = 16) or intermittent (n = 18) obstruction were studied. Endobronchial biopsy specimens were analyzed for airway smooth muscle area, epithelial detachment, basement membrane thickness, and submucosal fibrosis. Levels of eosinophil cationic protein, myeloperoxidase, matrix metalloproteinase 9, tissue inhibitor of matrix metalloproteinase 1 (ELISA), and 27 cytokines (multiplex assay) and differential cell counts were measured in induced sputum. Airway thickness was measured by means of high-resolution computed tomographic scanning.METHODSSubjects with severe asthma with chronic persistent (n = 16) or intermittent (n = 18) obstruction were studied. Endobronchial biopsy specimens were analyzed for airway smooth muscle area, epithelial detachment, basement membrane thickness, and submucosal fibrosis. Levels of eosinophil cationic protein, myeloperoxidase, matrix metalloproteinase 9, tissue inhibitor of matrix metalloproteinase 1 (ELISA), and 27 cytokines (multiplex assay) and differential cell counts were measured in induced sputum. Airway thickness was measured by means of high-resolution computed tomographic scanning.Chronic persistent obstruction was associated with earlier age of onset, longer disease duration, more inflammatory cells in the sputum, and greater smooth muscle area (15.65% +/- 2.69% [n = 10] vs 8.96% +/- 1.99% [n = 14], P = .0325). No differences between groups were found for any of the biomarker molecules measured in sputum individually. However, principal component analysis revealed that the dominant variables in the chronic persistent obstruction group were IL-12, IL-13, and IFN-gamma, whereas IL-9, IL-17, monocyte chemotactic protein 1, and RANTES were dominant in the other group. Airway imaging revealed no differences between groups.RESULTSChronic persistent obstruction was associated with earlier age of onset, longer disease duration, more inflammatory cells in the sputum, and greater smooth muscle area (15.65% +/- 2.69% [n = 10] vs 8.96% +/- 1.99% [n = 14], P = .0325). No differences between groups were found for any of the biomarker molecules measured in sputum individually. However, principal component analysis revealed that the dominant variables in the chronic persistent obstruction group were IL-12, IL-13, and IFN-gamma, whereas IL-9, IL-17, monocyte chemotactic protein 1, and RANTES were dominant in the other group. Airway imaging revealed no differences between groups.Subjects with severe asthma with chronic persistent obstruction have increased airway smooth muscle with ongoing T(H)1 and T(H)2 inflammatory responses. Neither airway measurements on high-resolution computed tomographic scans nor sputum analysis seem able to identify such patients.CONCLUSIONSubjects with severe asthma with chronic persistent obstruction have increased airway smooth muscle with ongoing T(H)1 and T(H)2 inflammatory responses. Neither airway measurements on high-resolution computed tomographic scans nor sputum analysis seem able to identify such patients. Background The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown. Objectives We sought to characterize subjects with severe asthma with and without chronic persistent airflow obstruction with respect to airway wall remodeling (histopathologic and radiologic) and specific sputum biomarkers. Methods Subjects with severe asthma with chronic persistent (n = 16) or intermittent (n = 18) obstruction were studied. Endobronchial biopsy specimens were analyzed for airway smooth muscle area, epithelial detachment, basement membrane thickness, and submucosal fibrosis. Levels of eosinophil cationic protein, myeloperoxidase, matrix metalloproteinase 9, tissue inhibitor of matrix metalloproteinase 1 (ELISA), and 27 cytokines (multiplex assay) and differential cell counts were measured in induced sputum. Airway thickness was measured by means of high-resolution computed tomographic scanning. Results Chronic persistent obstruction was associated with earlier age of onset, longer disease duration, more inflammatory cells in the sputum, and greater smooth muscle area (15.65% ± 2.69% [n = 10] vs 8.96% ± 1.99% [n = 14],P= .0325). No differences between groups were found for any of the biomarker molecules measured in sputum individually. However, principal component analysis revealed that the dominant variables in the chronic persistent obstruction group were IL-12, IL-13, and IFN-γ, whereas IL-9, IL-17, monocyte chemotactic protein 1, and RANTES were dominant in the other group. Airway imaging revealed no differences between groups. Conclusion Subjects with severe asthma with chronic persistent obstruction have increased airway smooth muscle with ongoing TH1 and TH2 inflammatory responses. Neither airway measurements on high-resolution computed tomographic scans nor sputum analysis seem able to identify such patients. |
| Author | Storness-Bliss, Claudine Lemière, Catherine Hamid, Qutayba Kaminska, Marta Ghezzo, Heberto Olivenstein, Ronald Ernst, Pierre Coxson, Harvey Maghni, Karim Martin, James Foley, Susan |
| Author_xml | – sequence: 1 givenname: Marta surname: Kaminska fullname: Kaminska, Marta organization: Meakins-Christie Laboratories, Montreal, Quebec, Canada – sequence: 2 givenname: Susan surname: Foley fullname: Foley, Susan organization: Meakins-Christie Laboratories, Montreal, Quebec, Canada – sequence: 3 givenname: Karim surname: Maghni fullname: Maghni, Karim organization: Centre de Recherche de l'Hopital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada – sequence: 4 givenname: Claudine surname: Storness-Bliss fullname: Storness-Bliss, Claudine organization: Department of Radiology and the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver General Hospital, Vancouver, British Columbia, Canada – sequence: 5 givenname: Harvey surname: Coxson fullname: Coxson, Harvey organization: Department of Radiology and the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver General Hospital, Vancouver, British Columbia, Canada – sequence: 6 givenname: Heberto surname: Ghezzo fullname: Ghezzo, Heberto organization: Meakins-Christie Laboratories, Montreal, Quebec, Canada – sequence: 7 givenname: Catherine surname: Lemière fullname: Lemière, Catherine organization: Centre de Recherche de l'Hopital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada – sequence: 8 givenname: Ronald surname: Olivenstein fullname: Olivenstein, Ronald organization: Meakins-Christie Laboratories, Montreal, Quebec, Canada – sequence: 9 givenname: Pierre surname: Ernst fullname: Ernst, Pierre organization: Meakins-Christie Laboratories, Montreal, Quebec, Canada – sequence: 10 givenname: Qutayba surname: Hamid fullname: Hamid, Qutayba organization: Meakins-Christie Laboratories, Montreal, Quebec, Canada – sequence: 11 givenname: James surname: Martin fullname: Martin, James email: james.martin@mcgill.ca organization: Meakins-Christie Laboratories, Montreal, Quebec, Canada |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21699090$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19481790$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkl2L1DAYhYOsuLOrf8ALCYh61ZqPfkVEWJb1Axa8UMG7kKZvd1I7yZikO8y_33RnXGHA8Sq0fc7bnHPeM3RinQWEnlOSU0Krt0M-KG1yRojICc9JIR6hBSWizqqGlSdokT7QrKoLcYrOQhhIeuaNeIJOqSgaWguyQDcXxm_UFntYuQ5GY2-wsThM7QA6BrwxcYkD3IIHrEJcrtTulfP3p5si1kvvrNF4DT6YEMFGrIzvR7fBrg3RTzoaZ5-ix70aAzzbn-fox8er75efs-uvn75cXlxnuixJzMp0P-iAV33FVSsItHUJRJVFKwThrWh7RXvacVVqxlinuuSkh4rVnDYN5SU_R292c9fe_Z4gRLkyQcM4KgtuCrKpK8abRtSJfH2UTLmxui6qBL48AAc3eZtcSFqSFGTBGU3Uiz01tSvo5NqblfJb-SfqBLzaAypoNfZeWW3CA8dolSzec82O096F4KGX2kQ1Zxi9MqOkRM7ty0HO7cu5fUm4TO0nKTuQPtzimOj9TgSpllsDXgZtwGrojE87IDtnjss_HMh12iKTHP6CLYS_UcnAJJHf5p2cVzJZJRWvf6YB7_494H9_vwPpGPES |
| CODEN | JACIBY |
| CitedBy_id | crossref_primary_10_1016_j_ccm_2012_06_008 crossref_primary_10_1111_all_13390 crossref_primary_10_1016_j_intimp_2018_12_061 crossref_primary_10_1016_j_waojou_2023_100848 crossref_primary_10_1111_resp_12198 crossref_primary_10_4049_jimmunol_1201827 crossref_primary_10_1155_2016_9868704 crossref_primary_10_1007_s00330_018_5913_1 crossref_primary_10_1007_s10753_015_0121_5 crossref_primary_10_1183_09031936_00002314 crossref_primary_10_1111_all_15739 crossref_primary_10_1165_rcmb_2010_0300OC crossref_primary_10_3389_fphys_2023_1113100 crossref_primary_10_1111_joim_12382 crossref_primary_10_1172_JCI90890 crossref_primary_10_1177_0300985817741729 crossref_primary_10_1016_j_rmed_2015_09_009 crossref_primary_10_22246_jikm_2023_44_3_294 crossref_primary_10_1016_S2213_2600_22_00185_0 crossref_primary_10_3390_cells11193047 crossref_primary_10_1164_rccm_201202_0203ED crossref_primary_10_1016_j_jaip_2015_05_005 crossref_primary_10_1016_j_jaip_2019_10_044 crossref_primary_10_1016_j_jaci_2009_11_028 crossref_primary_10_1165_rcmb_2014_0176OC crossref_primary_10_4168_aair_2010_2_3_165 crossref_primary_10_1016_j_rmed_2018_07_006 crossref_primary_10_1111_jgs_12218 crossref_primary_10_1007_s10753_022_01621_4 crossref_primary_10_1152_japplphysiol_01168_2009 crossref_primary_10_3109_02770903_2013_860164 crossref_primary_10_1111_all_13323 crossref_primary_10_1186_s12931_023_02529_9 crossref_primary_10_1016_j_jep_2020_113558 crossref_primary_10_1016_j_phrs_2015_12_018 crossref_primary_10_1186_s12931_017_0640_8 crossref_primary_10_1016_j_pharmthera_2011_02_001 crossref_primary_10_1016_j_rmed_2009_12_005 crossref_primary_10_1016_j_ejphar_2021_174692 crossref_primary_10_1016_j_jaci_2011_08_009 crossref_primary_10_1016_j_jaci_2011_12_1002 crossref_primary_10_1152_ajplung_00115_2011 crossref_primary_10_3109_02770903_2014_921196 crossref_primary_10_1152_japplphysiol_00468_2014 crossref_primary_10_1165_rcmb_2023_0469OC crossref_primary_10_2147_JAA_S403645 crossref_primary_10_1371_journal_pone_0048493 crossref_primary_10_1111_j_1440_1843_2009_01702_x crossref_primary_10_1038_srep02301 crossref_primary_10_1586_ers_12_12 crossref_primary_10_1159_000353427 crossref_primary_10_1164_rccm_201512_2452OC crossref_primary_10_1016_j_jaci_2013_09_039 crossref_primary_10_1186_1465_9921_15_57 crossref_primary_10_1111_cea_13714 crossref_primary_10_2147_JAA_S267222 crossref_primary_10_4168_aair_2010_2_2_59 crossref_primary_10_1016_S0140_6736_10_61087_2 crossref_primary_10_1080_02770903_2019_1611844 crossref_primary_10_1097_ACI_0b013e32833363b2 crossref_primary_10_1016_j_freeradbiomed_2022_04_011 crossref_primary_10_1016_j_mam_2011_10_015 crossref_primary_10_1164_rccm_201409_1582OC crossref_primary_10_3390_jof8020159 crossref_primary_10_1016_j_pupt_2012_08_003 crossref_primary_10_1165_rcmb_2019_0240ED crossref_primary_10_1016_j_jaip_2021_08_006 crossref_primary_10_1016_j_jaci_2013_03_044 crossref_primary_10_1097_MCP_0000000000000341 crossref_primary_10_1183_09031936_00202013 crossref_primary_10_1038_nm_2356 crossref_primary_10_1183_09031936_00063510 crossref_primary_10_1038_mi_2014_56 crossref_primary_10_1513_AnnalsATS_201304_087AW crossref_primary_10_1164_rccm_201507_1404OC crossref_primary_10_1016_j_jaci_2015_10_031 crossref_primary_10_1111_cea_13143 crossref_primary_10_1165_rcmb_2018_0352OC crossref_primary_10_1016_j_jff_2021_104465 crossref_primary_10_1152_ajplung_00373_2015 crossref_primary_10_1016_j_intimp_2020_106333 crossref_primary_10_1016_j_jaci_2012_08_044 crossref_primary_10_1016_j_smim_2019_101301 crossref_primary_10_1002_jmri_22388 crossref_primary_10_1186_1472_6882_13_221 crossref_primary_10_1038_s41598_019_43927_8 crossref_primary_10_1186_s40733_016_0021_y crossref_primary_10_1586_1744666X_2015_1072049 crossref_primary_10_1164_rccm_201410_1874OC crossref_primary_10_1016_j_jaci_2022_11_016 crossref_primary_10_1111_resp_13483 crossref_primary_10_1371_journal_pone_0086945 crossref_primary_10_3389_fped_2021_610478 crossref_primary_10_1002_cti2_1205 crossref_primary_10_1016_j_ccm_2012_05_002 crossref_primary_10_1016_j_waojou_2019_100078 crossref_primary_10_1155_2022_6879539 crossref_primary_10_1111_cea_13813 crossref_primary_10_1111_j_1365_2222_2011_03917_x crossref_primary_10_1152_ajplung_00106_2017 crossref_primary_10_1097_MCP_0b013e32834d09a5 crossref_primary_10_1378_chest_09_1895 crossref_primary_10_1165_rcmb_2011_0363OC crossref_primary_10_1007_s11882_020_00935_3 crossref_primary_10_1111_j_1440_1843_2011_02097_x crossref_primary_10_1152_ajplung_00123_2011 crossref_primary_10_1016_j_celrep_2022_110571 crossref_primary_10_1016_j_jaci_2012_01_059 crossref_primary_10_1186_s12865_021_00464_2 crossref_primary_10_1111_all_13003 crossref_primary_10_1371_journal_pone_0136284 crossref_primary_10_3390_cells8040342 crossref_primary_10_1016_j_jaci_2017_09_035 crossref_primary_10_1146_annurev_pathol_012414_040343 crossref_primary_10_1080_01902148_2019_1610116 crossref_primary_10_2214_AJR_11_8396 crossref_primary_10_1016_j_mam_2021_100969 crossref_primary_10_1097_CM9_0000000000001990 crossref_primary_10_1111_j_1365_2222_2009_03356_x crossref_primary_10_1186_s12931_024_02948_2 crossref_primary_10_1111_imr_70007 crossref_primary_10_1183_16000617_0045_2015 crossref_primary_10_3389_fphys_2022_993406 crossref_primary_10_1016_j_etap_2019_03_021 crossref_primary_10_1186_s12890_023_02803_y crossref_primary_10_1016_j_jflm_2018_05_003 crossref_primary_10_1186_s12931_024_02665_w crossref_primary_10_1165_rcmb_2024_0120ED crossref_primary_10_1016_j_crad_2024_09_005 crossref_primary_10_1155_2011_742710 crossref_primary_10_1165_rcmb_2012_0103OC crossref_primary_10_1097_ACI_0b013e3283312f84 crossref_primary_10_1016_j_iac_2022_04_001 crossref_primary_10_3389_fimmu_2019_02998 crossref_primary_10_1038_s41598_018_30895_8 crossref_primary_10_1183_09031936_00019810 crossref_primary_10_1038_s41598_020_67781_1 crossref_primary_10_1016_j_aller_2011_11_002 crossref_primary_10_1183_13993003_02298_2016 crossref_primary_10_1378_chest_09_3058 crossref_primary_10_1038_mi_2017_84 crossref_primary_10_1186_cc12740 crossref_primary_10_1016_j_anai_2017_10_004 crossref_primary_10_1016_j_ddmec_2012_11_004 crossref_primary_10_1016_j_jaci_2015_12_1332 crossref_primary_10_1134_S0026893315030188 crossref_primary_10_4049_jimmunol_1200009 crossref_primary_10_1016_j_rmed_2010_02_018 crossref_primary_10_1002_cbf_2926 crossref_primary_10_1007_s12010_023_04434_9 crossref_primary_10_3892_etm_2016_3509 crossref_primary_10_1164_rccm_201105_0915OC crossref_primary_10_1016_j_jaci_2009_09_047 crossref_primary_10_1152_ajplung_00050_2011 crossref_primary_10_1016_j_anai_2018_08_006 crossref_primary_10_1186_s40733_022_00084_6 crossref_primary_10_1016_j_smim_2019_101346 crossref_primary_10_1097_ACI_0b013e3283300baf |
| Cites_doi | 10.1164/rccm.200406-710ST 10.1038/sj.bjp.0705883 10.1164/ajrccm.164.9.2102039 10.1378/chest.07-1881 10.1183/0903.1936.98.12051219 10.1164/ajrccm.152.3.7663797 10.1164/ajrccm.163.4.2007119 10.1164/ajrccm.162.2.9907151 10.1183/09031936.98.12040811 10.1159/000113517 10.1183/09031936.02.00002402 10.1164/ajrccm/142.3.563 10.1164/ajrccm.154.2.8756799 10.1186/1465-9921-7-46 10.1183/09031936.04.00004904 10.1164/ajrccm.162.4.9909044 10.1117/12.463615 10.1164/ajrccm.162.6.ats9-00 10.1111/j.1398-9995.2008.01656.x 10.1172/JCI5809 10.1002/jcp.20992 10.1136/thorax.57.3.242 10.1164/rccm.200207-710OC 10.1183/09031936.03.00085302 10.1164/rccm.200609-1317OC 10.1152/jappl.2001.90.2.734 10.1016/j.amjmed.2003.11.026 10.1164/ajrccm.162.4.9912138 10.1165/ajrcmb.17.3.2733 10.1016/j.jaci.2008.01.015 10.1016/j.jaci.2006.08.003 10.1038/nature06014 10.1152/japplphysiol.00884.2004 10.1056/NEJMoa064707 10.1164/rccm.200309-1238OC 10.1136/thorax.57.3.247 10.1085/jgp.105.1.73 10.1164/ajrccm.159.4.9806052 10.1164/ajrccm.152.5.7582278 10.1016/j.jaci.2005.08.018 10.1385/CRIAI:27:1:001 10.1152/ajplung.00363.2002 10.1164/ajrccm.152.3.7663792 10.1016/j.jaci.2005.06.011 10.1007/s00408-006-0007-2 10.1172/JCI17974 10.1152/jappl.1994.77.3.1206 10.1164/rccm.200209-1030OC 10.1164/ajrccm/147.2.405 |
| ContentType | Journal Article |
| Copyright | 2009 American Academy of Allergy, Asthma & Immunology American Academy of Allergy, Asthma & Immunology 2009 INIST-CNRS Copyright Elsevier Limited Jul 2009 |
| Copyright_xml | – notice: 2009 American Academy of Allergy, Asthma & Immunology – notice: American Academy of Allergy, Asthma & Immunology – notice: 2009 INIST-CNRS – notice: Copyright Elsevier Limited Jul 2009 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7SS 7T5 H94 K9. NAPCQ 7X8 |
| DOI | 10.1016/j.jaci.2009.03.049 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Entomology Abstracts (Full archive) Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Entomology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Immunology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Entomology Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1097-6825 |
| EndPage | 51.e4 |
| ExternalDocumentID | 3239329471 19481790 21699090 10_1016_j_jaci_2009_03_049 S009167490900637X 1_s2_0_S009167490900637X |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Canada Montreal Quebec Canada |
| GeographicLocations_xml | – name: Canada – name: Montreal Quebec Canada |
| GroupedDBID | --- --K --M -~X .1- .55 .FO .GJ .XZ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 354 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8F7 8FE 8FH 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABJNI ABLJU ABMAC ABMZM ABOCM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACPRK ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADFRT ADMUD ADNMO ADVLN ADXHL AEBSH AEIPS AEKER AENEX AEUPX AFFNX AFJKZ AFPUW AFRAH AFRHN AFTJW AFXIZ AGCQF AGEKW AGHFR AGQPQ AGUBO AGYEJ AHHHB AHMBA AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV BPHCQ BVXVI C45 CAG CJTIS COF CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDU HMK HMO HVGLF HZ~ IHE J1W J5H K-O KOM L7B LK8 LUGTX M27 M41 MO0 N4W N9A O-L O9- O9~ OAUVE OBH ODZKP OHH OHT OK0 OK1 OVD OZT P-8 P-9 P2P PC. PQQKQ PROAC Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SJN SPCBC SSH SSI SSZ T5K TEORI TWZ UGJ UNMZH UV1 WH7 WOW WUQ X7M XFW YOC YQI YQJ Z5R ZGI ZXP ZY1 ~02 ~G- ~KM AACTN RIG AAYXX AGRNS CITATION IQODW CGR CUY CVF ECM EIF NPM 7SS 7T5 H94 K9. NAPCQ 7X8 |
| ID | FETCH-LOGICAL-c550t-5389ede36f63ab90eb75e0a54b9903b9bfa1f1d3a5c222dad194fe62731881353 |
| IEDL.DBID | .~1 |
| ISSN | 0091-6749 1097-6825 |
| IngestDate | Thu Jul 10 22:40:31 EDT 2025 Tue Aug 05 11:01:30 EDT 2025 Wed Aug 13 09:46:12 EDT 2025 Mon Jul 21 05:52:41 EDT 2025 Mon Jul 21 09:17:13 EDT 2025 Tue Jul 01 04:31:51 EDT 2025 Thu Apr 24 22:56:54 EDT 2025 Sun Apr 06 06:54:17 EDT 2025 Wed Apr 02 07:27:49 EDT 2025 Tue Aug 26 17:58:53 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | reticular basement membrane ATS FeNO remodeling SMA airway smooth muscle sputum WA MPO high-resolution computed tomographic scan CT MMP ECP inflammation MIP biopsy fibrosis cytokines HRCT Severe asthma ASM MCP RBM TIMP Fraction of exhaled nitric oxide Matrix metalloproteinase Computed tomography Smooth muscle area Myeloperoxidase Wall area percentage Monocyte chemotactic protein High-resolution computed tomography American Thoracic Society Tissue inhibitor of matrix metalloproteinase Eosinophil cationic protein Macrophage inflammatory protein High resolution Smooth muscle Remodeling Respiratory system Obstruction Respiratory tract Immunology Human Immunopathology Radiodiagnosis Cytokine Inflammation Basement membrane Anatomic pathology Chronic Biopsy Sputum Fibrosis Medical imagery Computerized axial tomography |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c550t-5389ede36f63ab90eb75e0a54b9903b9bfa1f1d3a5c222dad194fe62731881353 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 19481790 |
| PQID | 1504814321 |
| PQPubID | 105664 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_876238897 proquest_miscellaneous_67427746 proquest_journals_1504814321 pubmed_primary_19481790 pascalfrancis_primary_21699090 crossref_citationtrail_10_1016_j_jaci_2009_03_049 crossref_primary_10_1016_j_jaci_2009_03_049 elsevier_sciencedirect_doi_10_1016_j_jaci_2009_03_049 elsevier_clinicalkeyesjournals_1_s2_0_S009167490900637X elsevier_clinicalkey_doi_10_1016_j_jaci_2009_03_049 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-07-01 |
| PublicationDateYYYYMMDD | 2009-07-01 |
| PublicationDate_xml | – month: 07 year: 2009 text: 2009-07-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States – name: St. Louis |
| PublicationTitle | Journal of allergy and clinical immunology |
| PublicationTitleAlternate | J Allergy Clin Immunol |
| PublicationYear | 2009 |
| Publisher | Mosby, Inc Elsevier Elsevier Limited |
| Publisher_xml | – name: Mosby, Inc – name: Elsevier – name: Elsevier Limited |
| References | Minshall, Leung, Martin, Song, Cameron, Ernst (bib14) 1997; 17 Gono, Fujimoto, Kawakami, Kubo (bib34) 2003; 22 Liang, Lee, Lin, Lin, Wu, Luo (bib46) 2007; 211 Kasahara, Shiba, Ozawa, Okuda, Adachi (bib30) 2002; 57 Bai (bib24) 2004; 97 Sont, Willems, Bel, van Krieken, Vandenbroucke, Sterk (bib28) 1999; 159 Lemiere, Ernst, Olivenstein, Yamauchi, Govindaraju, Ludwig (bib9) 2006; 118 Capraz, Kunter, Cermik, Ilvan, Pocan (bib33) 2007; 185 Bosse, Thompson, Audette, Stankova, Rola-Pleszczynski (bib42) 2008; 146 Niimi, Matsumoto, Amitani, Nakano, Mishima, Minakuchi (bib35) 2000; 162 Niimi, Matsumoto, Amitani, Nakano, Sakai, Takemura (bib32) 2004; 116 Lambert, Codd, Alley, Pack (bib22) 1994; 77 Pizzichini, Pizzichini, Efthimiadis, Evans, Morris, Squillace (bib10) 1996; 154 (bib16) 2008 Little, Sproule, Cowan, Macleod, Robertson, Love (bib29) 2002; 57 Saglani, Papaioannou, Khoo, Ujita, Jeffery, Owens (bib31) 2006; 7 Pepe, Foley, Shannon, Lemiere, Olivenstein, Ernst (bib4) 2005; 116 Shannon, Ernst, Yamauchi, Olivenstein, Lemiere, Foley (bib12) 2008; 133 Noonan, Chervinsky, Busse, Weisberg, Pinnas, de Boisblanc (bib2) 1995; 152 Hakonarson, Maskeri, Carter, Grunstein (bib44) 1999; 103 (bib11) 2005; 171 Tillie-Leblond (bib21) 2008; 63 Benayoun, Druilhe, Dombret, Aubier, Pretolani (bib6) 2003; 167 Nakagawa, Hoshino (bib3) 2004; 27 Antonicelli, Bucca, Neri, De Benedetto, Sabbatani, Bonifazi (bib1) 2004; 23 Nakano, Whittall, Kalloger, Coxson, Pare (bib37) 2002; 4683 Carroll, Elliot, Morton, James (bib5) 1993; 147 Pratusevich, Seow, Ford (bib23) 1995; 105 Wang, Pare, Seow (bib25) 2001; 90 Brown RH, SN, Mudge B, Diemer FB, Permutt S, Togias A. High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma. Am J Respir Crit Care Med 2001;163:994-1001. (bib8) 2000; 162 Maghni, Lemiere, Ghezzo, Yuquan, Malo (bib15) 2004; 169 Bai, Cooper, Koelmeyer, Pare, Weir (bib18) 2000; 162 Kelly, Keatings, Leigh, Peterson, Shute, Venge (bib7) 2002; 20 Brown, Salome, Berend, Thorpe, King (bib38) 2007; 176 Amrani, Tliba, Choubey, Huang, Krymskaya, Eszterhas (bib43) 2003; 284 Moffatt, Kabesch, Liang, Dixon, Strachan, Heath (bib19) 2007; 448 Boulet, Belanger, Carrier (bib36) 1995; 152 Chetta, Zanini, Foresi, Del Donno, Castagnaro, D'Ippolito (bib27) 2003; 167 Flood-Page, Menzies-Gow, Phipps, Ying, Wangoo, Ludwig (bib41) 2003; 112 Elshaw, Henderson, Knox, Watson, Buttle, Johnson (bib45) 2004; 142 Tavendale, Macgregor, Mukhopadhyay, Palmer (bib20) 2008; 121 Ward, Johns, Bish, Pais, Reid, Ingram (bib40) 2001; 164 Sullivan, Stephens, Ansari, Costello, Jeffery (bib13) 1998; 12 Miller, Johnson, Miller, Deniz, Bleecker, Wenzel (bib17) 2005; 116 Cox, Thomson, Rubin, Niven, Corris, Siersted (bib47) 2007; 356 Pellegrino, Sterk, Sont, Brusaco (bib26) 1998; 12 Bosse (10.1016/j.jaci.2009.03.049_bib42) 2008; 146 Nakagawa (10.1016/j.jaci.2009.03.049_bib3) 2004; 27 Pizzichini (10.1016/j.jaci.2009.03.049_E4) 1996; 154 Gono (10.1016/j.jaci.2009.03.049_bib34) 2003; 22 Liang (10.1016/j.jaci.2009.03.049_bib46) 2007; 211 Flood-Page (10.1016/j.jaci.2009.03.049_bib41) 2003; 112 (10.1016/j.jaci.2009.03.049_E3) 1995; 152 Antonicelli (10.1016/j.jaci.2009.03.049_bib1) 2004; 23 Sullivan (10.1016/j.jaci.2009.03.049_bib13) 1998; 12 Cox (10.1016/j.jaci.2009.03.049_bib47) 2007; 356 Pellegrino (10.1016/j.jaci.2009.03.049_bib26) 1998; 12 Niimi (10.1016/j.jaci.2009.03.049_bib35) 2000; 162 Sont (10.1016/j.jaci.2009.03.049_bib28) 1999; 159 Little (10.1016/j.jaci.2009.03.049_bib29) 2002; 57 Ward (10.1016/j.jaci.2009.03.049_bib40) 2001; 164 Maghni (10.1016/j.jaci.2009.03.049_bib15) 2004; 169 Bai (10.1016/j.jaci.2009.03.049_bib18) 2000; 162 Nakano (10.1016/j.jaci.2009.03.049_bib37) 2002; 4683 Niimi (10.1016/j.jaci.2009.03.049_bib32) 2004; 116 Noonan (10.1016/j.jaci.2009.03.049_bib2) 1995; 152 Boulet (10.1016/j.jaci.2009.03.049_bib36) 1995; 152 Hakonarson (10.1016/j.jaci.2009.03.049_bib44) 1999; 103 Juniper (10.1016/j.jaci.2009.03.049_E2) 2000; 162 Lambert (10.1016/j.jaci.2009.03.049_bib22) 1994; 77 Kasahara (10.1016/j.jaci.2009.03.049_bib30) 2002; 57 Capraz (10.1016/j.jaci.2009.03.049_bib33) 2007; 185 Bosken (10.1016/j.jaci.2009.03.049_E5) 1990; 142 Pepe (10.1016/j.jaci.2009.03.049_bib4) 2005; 116 Kelly (10.1016/j.jaci.2009.03.049_bib7) 2002; 20 (10.1016/j.jaci.2009.03.049_bib16) 2008 Chetta (10.1016/j.jaci.2009.03.049_bib27) 2003; 167 Bai (10.1016/j.jaci.2009.03.049_bib24) 2004; 97 (10.1016/j.jaci.2009.03.049_E1) 2000; 162 Benayoun (10.1016/j.jaci.2009.03.049_bib6) 2003; 167 Saglani (10.1016/j.jaci.2009.03.049_bib31) 2006; 7 Moffatt (10.1016/j.jaci.2009.03.049_bib19) 2007; 448 Carroll (10.1016/j.jaci.2009.03.049_bib5) 1993; 147 10.1016/j.jaci.2009.03.049_bib39 Minshall (10.1016/j.jaci.2009.03.049_bib14) 1997; 17 (10.1016/j.jaci.2009.03.049_bib11) 2005; 171 Tillie-Leblond (10.1016/j.jaci.2009.03.049_bib21) 2008; 63 Brown (10.1016/j.jaci.2009.03.049_bib38) 2007; 176 (10.1016/j.jaci.2009.03.049_bib8) 2000; 162 Pizzichini (10.1016/j.jaci.2009.03.049_bib10) 1996; 154 Amrani (10.1016/j.jaci.2009.03.049_bib43) 2003; 284 Wang (10.1016/j.jaci.2009.03.049_bib25) 2001; 90 Elshaw (10.1016/j.jaci.2009.03.049_bib45) 2004; 142 Tavendale (10.1016/j.jaci.2009.03.049_bib20) 2008; 121 Miller (10.1016/j.jaci.2009.03.049_bib17) 2005; 116 Shannon (10.1016/j.jaci.2009.03.049_bib12) 2008; 133 Lemiere (10.1016/j.jaci.2009.03.049_bib9) 2006; 118 Nakano (10.1016/j.jaci.2009.03.049_E6) 2002; 4683 Pratusevich (10.1016/j.jaci.2009.03.049_bib23) 1995; 105 |
| References_xml | – volume: 12 start-page: 811 year: 1998 end-page: 815 ident: bib13 article-title: Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies publication-title: Eur Respir J – volume: 152 start-page: 1467 year: 1995 end-page: 1473 ident: bib2 article-title: Fluticasone propionate reduces oral prednisone use while it improves asthma control and quality of life publication-title: Am J Respir Crit Care Med – volume: 105 start-page: 73 year: 1995 end-page: 94 ident: bib23 article-title: Plasticity in canine airway smooth muscle publication-title: J Gen Physiol – volume: 159 start-page: 1043 year: 1999 end-page: 1051 ident: bib28 article-title: Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment publication-title: Am J Respir Crit Care Med – volume: 27 start-page: 1 year: 2004 end-page: 2 ident: bib3 article-title: Airway remodeling in asthma: an introduction publication-title: Clin Rev Allergy Immunol – volume: 133 start-page: 420 year: 2008 end-page: 426 ident: bib12 article-title: Differences in airway cytokine profile in severe asthma compared to moderate asthma publication-title: Chest – volume: 211 start-page: 759 year: 2007 end-page: 770 ident: bib46 article-title: Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells publication-title: J Cell Physiol – reference: Brown RH, SN, Mudge B, Diemer FB, Permutt S, Togias A. High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma. Am J Respir Crit Care Med 2001;163:994-1001. – volume: 22 start-page: 965 year: 2003 end-page: 971 ident: bib34 article-title: Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma publication-title: Eur J Respir Dis – volume: 169 start-page: 367 year: 2004 end-page: 372 ident: bib15 article-title: Airway inflammation after cessation of exposure to agents causing occupational asthma publication-title: Am J Respir Crit Care Med – volume: 17 start-page: 326 year: 1997 end-page: 333 ident: bib14 article-title: Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma publication-title: Am J Respir Cell Mol Biol – volume: 116 start-page: 544 year: 2005 end-page: 549 ident: bib4 article-title: Differences in airway remodeling between subjects with severe and moderate asthma publication-title: J Allergy Clin Immunol – volume: 116 start-page: 725 year: 2004 end-page: 731 ident: bib32 article-title: Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma publication-title: Am J Med – volume: 63 start-page: 533 year: 2008 end-page: 541 ident: bib21 article-title: Airway remodeling is correlated with obstruction in children with severe asthma publication-title: Allergy – volume: 176 start-page: 129 year: 2007 end-page: 137 ident: bib38 article-title: Airway distensibility in adults with asthma and healthy adults, measured by forced oscillation technique publication-title: Am J Respir Crit Care Med – volume: 154 start-page: 308 year: 1996 end-page: 317 ident: bib10 article-title: Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements publication-title: Am J Respir Crit Care Med – volume: 103 start-page: 1077 year: 1999 end-page: 1087 ident: bib44 article-title: Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle publication-title: J Clin Invest – volume: 112 start-page: 1029 year: 2003 end-page: 1036 ident: bib41 article-title: Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics publication-title: J Clin Invest – volume: 167 start-page: 1360 year: 2003 end-page: 1368 ident: bib6 article-title: Airway structural alterations selectively associated with severe asthma publication-title: Am J Respir Crit Care Med – volume: 57 start-page: 242 year: 2002 end-page: 246 ident: bib30 article-title: Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma publication-title: Thorax – volume: 284 start-page: L1063 year: 2003 end-page: L1071 ident: bib43 article-title: IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway publication-title: Am J Physiol Lung Cell Mol Physiol – volume: 162 start-page: 1518 year: 2000 end-page: 1523 ident: bib35 article-title: Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices publication-title: Am J Respir Crit Care Med – volume: 164 start-page: 1718 year: 2001 end-page: 1721 ident: bib40 article-title: Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma publication-title: Am J Respir Crit Care Med – volume: 162 start-page: 663 year: 2000 end-page: 669 ident: bib18 article-title: The effect of age and duration of disease on airway structure in fatal asthma publication-title: Am J Respir Crit Care Med – volume: 167 start-page: 751 year: 2003 end-page: 757 ident: bib27 article-title: Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone publication-title: Am J Respir Crit Care Med – volume: 152 start-page: 865 year: 1995 end-page: 871 ident: bib36 article-title: Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction publication-title: Am J Respir Crit Care Med – volume: 356 start-page: 1327 year: 2007 end-page: 1337 ident: bib47 article-title: Asthma control during the year after bronchial thermoplasty publication-title: N Engl J Med – volume: 7 start-page: 46 year: 2006 ident: bib31 article-title: Can HRCT be used as a marker of airway remodelling in children with difficult asthma? publication-title: Respir Res – volume: 90 start-page: 734 year: 2001 end-page: 740 ident: bib25 article-title: Plasticity in skeletal, cardiac, and smooth muscle: selected contribution: effect of chronic passive length change on airway smooth muscle length-tension relationship publication-title: J Appl Physiol – volume: 20 start-page: 24S year: 2002 end-page: 39S ident: bib7 article-title: Analysis of fluid-phase mediators publication-title: Eur Respir J – volume: 171 start-page: 912 year: 2005 end-page: 930 ident: bib11 article-title: ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 publication-title: Am J Respir Crit Care Med – volume: 4683 start-page: 460 year: 2002 end-page: 469 ident: bib37 article-title: Development and validation of human airway analysis algorithm using multidetector row CT publication-title: Proceedings of SPIE – volume: 97 start-page: 2029 year: 2004 end-page: 2034 ident: bib24 article-title: On the terminology for describing the length-force relationship and its changes in airway smooth muscle publication-title: J Appl Physiol – volume: 185 start-page: 89 year: 2007 end-page: 96 ident: bib33 article-title: The effect of inhaled budesonide and formoterol on bronchial remodeling and HRCT features in young asthmatics publication-title: Lung – volume: 142 start-page: 1318 year: 2004 end-page: 1324 ident: bib45 article-title: Matrix metalloproteinase expression and activity in human airway smooth muscle cells publication-title: Br J Pharmacol – volume: 23 start-page: 723 year: 2004 end-page: 729 ident: bib1 article-title: Asthma severity and medical resource utilization publication-title: Eur Respir J – volume: 116 start-page: 990 year: 2005 end-page: 995 ident: bib17 article-title: Severity assessment in asthma: an evolving concept publication-title: J Allergy Clin Immunol – volume: 12 start-page: 1219 year: 1998 end-page: 1227 ident: bib26 article-title: Assessing the effect of deep inhalation on airway calibre: a novel approach to lung function in bronchial asthma and COPD publication-title: Eur Respir J – volume: 77 start-page: 1206 year: 1994 end-page: 1216 ident: bib22 article-title: Physical determinants of bronchial mucosal folding publication-title: J Appl Physiol – volume: 147 start-page: 405 year: 1993 end-page: 410 ident: bib5 article-title: The structure of large and small airways in nonfatal and fatal asthma publication-title: Am Rev Respir Dis – year: 2008 ident: bib16 article-title: R: a language and environment for statistical computing publication-title: R Foundation for Statistical Computing – volume: 57 start-page: 247 year: 2002 end-page: 253 ident: bib29 article-title: High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity publication-title: Thorax – volume: 118 start-page: 1033 year: 2006 end-page: 1039 ident: bib9 article-title: Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes publication-title: J Allergy Clin Immunol – volume: 146 start-page: 138 year: 2008 end-page: 148 ident: bib42 article-title: Interleukin-4 and interleukin-13 enhance human bronchial smooth muscle cell proliferation publication-title: Int Arch Allergy Immunol – volume: 448 start-page: 470 year: 2007 end-page: 473 ident: bib19 article-title: Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma publication-title: Nature – volume: 121 start-page: 860 year: 2008 end-page: 863 ident: bib20 article-title: A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications publication-title: J Allergy Clin Immunol – volume: 162 start-page: 2341 year: 2000 end-page: 2351 ident: bib8 article-title: Current understanding, recommendations, and unanswered questions publication-title: Am J Respir Crit Care Med – volume: 171 start-page: 912 year: 2005 ident: 10.1016/j.jaci.2009.03.049_bib11 article-title: ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200406-710ST – volume: 142 start-page: 1318 year: 2004 ident: 10.1016/j.jaci.2009.03.049_bib45 article-title: Matrix metalloproteinase expression and activity in human airway smooth muscle cells publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0705883 – volume: 164 start-page: 1718 year: 2001 ident: 10.1016/j.jaci.2009.03.049_bib40 article-title: Reduced airway distensibility, fixed airflow limitation, and airway wall remodeling in asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.164.9.2102039 – volume: 133 start-page: 420 year: 2008 ident: 10.1016/j.jaci.2009.03.049_bib12 article-title: Differences in airway cytokine profile in severe asthma compared to moderate asthma publication-title: Chest doi: 10.1378/chest.07-1881 – volume: 12 start-page: 1219 year: 1998 ident: 10.1016/j.jaci.2009.03.049_bib26 article-title: Assessing the effect of deep inhalation on airway calibre: a novel approach to lung function in bronchial asthma and COPD publication-title: Eur Respir J doi: 10.1183/0903.1936.98.12051219 – volume: 152 start-page: 865 year: 1995 ident: 10.1016/j.jaci.2009.03.049_bib36 article-title: Airway responsiveness and bronchial-wall thickness in asthma with or without fixed airflow obstruction publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.152.3.7663797 – ident: 10.1016/j.jaci.2009.03.049_bib39 doi: 10.1164/ajrccm.163.4.2007119 – volume: 162 start-page: 663 year: 2000 ident: 10.1016/j.jaci.2009.03.049_bib18 article-title: The effect of age and duration of disease on airway structure in fatal asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.162.2.9907151 – volume: 12 start-page: 811 year: 1998 ident: 10.1016/j.jaci.2009.03.049_bib13 article-title: Variation in the measurements of basement membrane thickness and inflammatory cell number in bronchial biopsies publication-title: Eur Respir J doi: 10.1183/09031936.98.12040811 – volume: 146 start-page: 138 year: 2008 ident: 10.1016/j.jaci.2009.03.049_bib42 article-title: Interleukin-4 and interleukin-13 enhance human bronchial smooth muscle cell proliferation publication-title: Int Arch Allergy Immunol doi: 10.1159/000113517 – volume: 20 start-page: 24S issue: suppl year: 2002 ident: 10.1016/j.jaci.2009.03.049_bib7 article-title: Analysis of fluid-phase mediators publication-title: Eur Respir J doi: 10.1183/09031936.02.00002402 – volume: 142 start-page: 563 year: 1990 ident: 10.1016/j.jaci.2009.03.049_E5 article-title: Small airway dimensions in smokers with obstruction to airflow publication-title: Am Rev Respir Dis doi: 10.1164/ajrccm/142.3.563 – volume: 154 start-page: 308 year: 1996 ident: 10.1016/j.jaci.2009.03.049_E4 article-title: Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.154.2.8756799 – volume: 7 start-page: 46 year: 2006 ident: 10.1016/j.jaci.2009.03.049_bib31 article-title: Can HRCT be used as a marker of airway remodelling in children with difficult asthma? publication-title: Respir Res doi: 10.1186/1465-9921-7-46 – volume: 23 start-page: 723 year: 2004 ident: 10.1016/j.jaci.2009.03.049_bib1 article-title: Asthma severity and medical resource utilization publication-title: Eur Respir J doi: 10.1183/09031936.04.00004904 – volume: 162 start-page: 1518 year: 2000 ident: 10.1016/j.jaci.2009.03.049_bib35 article-title: Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.162.4.9909044 – volume: 4683 start-page: 460 year: 2002 ident: 10.1016/j.jaci.2009.03.049_bib37 article-title: Development and validation of human airway analysis algorithm using multidetector row CT publication-title: Proceedings of SPIE doi: 10.1117/12.463615 – volume: 162 start-page: 2341 year: 2000 ident: 10.1016/j.jaci.2009.03.049_E1 article-title: Current understanding, recommendations, and unanswered questions publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.162.6.ats9-00 – volume: 63 start-page: 533 year: 2008 ident: 10.1016/j.jaci.2009.03.049_bib21 article-title: Airway remodeling is correlated with obstruction in children with severe asthma publication-title: Allergy doi: 10.1111/j.1398-9995.2008.01656.x – volume: 103 start-page: 1077 year: 1999 ident: 10.1016/j.jaci.2009.03.049_bib44 article-title: Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle publication-title: J Clin Invest doi: 10.1172/JCI5809 – volume: 211 start-page: 759 year: 2007 ident: 10.1016/j.jaci.2009.03.049_bib46 article-title: Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells publication-title: J Cell Physiol doi: 10.1002/jcp.20992 – volume: 57 start-page: 242 year: 2002 ident: 10.1016/j.jaci.2009.03.049_bib30 article-title: Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma publication-title: Thorax doi: 10.1136/thorax.57.3.242 – volume: 154 start-page: 308 year: 1996 ident: 10.1016/j.jaci.2009.03.049_bib10 article-title: Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.154.2.8756799 – volume: 167 start-page: 751 year: 2003 ident: 10.1016/j.jaci.2009.03.049_bib27 article-title: Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200207-710OC – volume: 22 start-page: 965 year: 2003 ident: 10.1016/j.jaci.2009.03.049_bib34 article-title: Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma publication-title: Eur J Respir Dis doi: 10.1183/09031936.03.00085302 – volume: 176 start-page: 129 year: 2007 ident: 10.1016/j.jaci.2009.03.049_bib38 article-title: Airway distensibility in adults with asthma and healthy adults, measured by forced oscillation technique publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200609-1317OC – volume: 90 start-page: 734 year: 2001 ident: 10.1016/j.jaci.2009.03.049_bib25 article-title: Plasticity in skeletal, cardiac, and smooth muscle: selected contribution: effect of chronic passive length change on airway smooth muscle length-tension relationship publication-title: J Appl Physiol doi: 10.1152/jappl.2001.90.2.734 – volume: 116 start-page: 725 year: 2004 ident: 10.1016/j.jaci.2009.03.049_bib32 article-title: Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma publication-title: Am J Med doi: 10.1016/j.amjmed.2003.11.026 – volume: 162 start-page: 1330 year: 2000 ident: 10.1016/j.jaci.2009.03.049_E2 article-title: Measuring asthma control. Clinic questionnaire or daily diary? publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.162.4.9912138 – volume: 17 start-page: 326 year: 1997 ident: 10.1016/j.jaci.2009.03.049_bib14 article-title: Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma publication-title: Am J Respir Cell Mol Biol doi: 10.1165/ajrcmb.17.3.2733 – volume: 121 start-page: 860 year: 2008 ident: 10.1016/j.jaci.2009.03.049_bib20 article-title: A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2008.01.015 – volume: 118 start-page: 1033 year: 2006 ident: 10.1016/j.jaci.2009.03.049_bib9 article-title: Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.08.003 – volume: 448 start-page: 470 year: 2007 ident: 10.1016/j.jaci.2009.03.049_bib19 article-title: Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma publication-title: Nature doi: 10.1038/nature06014 – volume: 97 start-page: 2029 year: 2004 ident: 10.1016/j.jaci.2009.03.049_bib24 article-title: On the terminology for describing the length-force relationship and its changes in airway smooth muscle publication-title: J Appl Physiol doi: 10.1152/japplphysiol.00884.2004 – volume: 356 start-page: 1327 year: 2007 ident: 10.1016/j.jaci.2009.03.049_bib47 article-title: Asthma control during the year after bronchial thermoplasty publication-title: N Engl J Med doi: 10.1056/NEJMoa064707 – volume: 169 start-page: 367 year: 2004 ident: 10.1016/j.jaci.2009.03.049_bib15 article-title: Airway inflammation after cessation of exposure to agents causing occupational asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200309-1238OC – volume: 57 start-page: 247 year: 2002 ident: 10.1016/j.jaci.2009.03.049_bib29 article-title: High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity publication-title: Thorax doi: 10.1136/thorax.57.3.247 – volume: 105 start-page: 73 year: 1995 ident: 10.1016/j.jaci.2009.03.049_bib23 article-title: Plasticity in canine airway smooth muscle publication-title: J Gen Physiol doi: 10.1085/jgp.105.1.73 – volume: 159 start-page: 1043 year: 1999 ident: 10.1016/j.jaci.2009.03.049_bib28 article-title: Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.159.4.9806052 – volume: 152 start-page: 1467 year: 1995 ident: 10.1016/j.jaci.2009.03.049_bib2 article-title: Fluticasone propionate reduces oral prednisone use while it improves asthma control and quality of life publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.152.5.7582278 – volume: 116 start-page: 990 year: 2005 ident: 10.1016/j.jaci.2009.03.049_bib17 article-title: Severity assessment in asthma: an evolving concept publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2005.08.018 – volume: 27 start-page: 1 year: 2004 ident: 10.1016/j.jaci.2009.03.049_bib3 article-title: Airway remodeling in asthma: an introduction publication-title: Clin Rev Allergy Immunol doi: 10.1385/CRIAI:27:1:001 – volume: 284 start-page: L1063 year: 2003 ident: 10.1016/j.jaci.2009.03.049_bib43 article-title: IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway publication-title: Am J Physiol Lung Cell Mol Physiol doi: 10.1152/ajplung.00363.2002 – volume: 152 start-page: 1107 year: 1995 ident: 10.1016/j.jaci.2009.03.049_E3 article-title: Standardization of spirometry, 1994 update publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.152.3.7663792 – volume: 162 start-page: 2341 year: 2000 ident: 10.1016/j.jaci.2009.03.049_bib8 article-title: Current understanding, recommendations, and unanswered questions publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.162.6.ats9-00 – volume: 116 start-page: 544 year: 2005 ident: 10.1016/j.jaci.2009.03.049_bib4 article-title: Differences in airway remodeling between subjects with severe and moderate asthma publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2005.06.011 – volume: 185 start-page: 89 year: 2007 ident: 10.1016/j.jaci.2009.03.049_bib33 article-title: The effect of inhaled budesonide and formoterol on bronchial remodeling and HRCT features in young asthmatics publication-title: Lung doi: 10.1007/s00408-006-0007-2 – volume: 4683 start-page: 460 year: 2002 ident: 10.1016/j.jaci.2009.03.049_E6 article-title: Development and validation of human airway analysis algorithm using multidetector row CT publication-title: Proceedings of SPIE doi: 10.1117/12.463615 – year: 2008 ident: 10.1016/j.jaci.2009.03.049_bib16 article-title: R: a language and environment for statistical computing publication-title: R Foundation for Statistical Computing – volume: 112 start-page: 1029 year: 2003 ident: 10.1016/j.jaci.2009.03.049_bib41 article-title: Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics publication-title: J Clin Invest doi: 10.1172/JCI17974 – volume: 77 start-page: 1206 year: 1994 ident: 10.1016/j.jaci.2009.03.049_bib22 article-title: Physical determinants of bronchial mucosal folding publication-title: J Appl Physiol doi: 10.1152/jappl.1994.77.3.1206 – volume: 167 start-page: 1360 year: 2003 ident: 10.1016/j.jaci.2009.03.049_bib6 article-title: Airway structural alterations selectively associated with severe asthma publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200209-1030OC – volume: 147 start-page: 405 year: 1993 ident: 10.1016/j.jaci.2009.03.049_bib5 article-title: The structure of large and small airways in nonfatal and fatal asthma publication-title: Am Rev Respir Dis doi: 10.1164/ajrccm/147.2.405 |
| SSID | ssj0009389 |
| Score | 2.3876398 |
| Snippet | The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown.
We sought to characterize subjects with... Background The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown. Objectives We sought to... The patterns of airway remodeling and the biomarkers that distinguish different subtypes of severe asthma are unknown.BACKGROUNDThe patterns of airway... |
| SourceID | proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 45 |
| SubjectTerms | Adult Airway management airway smooth muscle Allergy and Immunology Asthma Asthma - pathology Biological and medical sciences biopsy Chemokines cytokines Female fibrosis Fundamental and applied biological sciences. Psychology Fundamental immunology Granulocytes - metabolism high-resolution computed tomographic scan Humans Immunopathology inflammation Male Matrix Metalloproteinase 9 - metabolism Medical sciences Methods Middle Aged Molecular weight Muscle, Smooth - pathology Muscular system Proteins Pulmonary Disease, Chronic Obstructive - pathology remodeling Respiratory System - diagnostic imaging Respiratory System - pathology reticular basement membrane Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severe asthma Smooth muscle sputum Sputum - immunology Tissue Inhibitor of Metalloproteinase-1 - metabolism Tomography, X-Ray Computed Values Vascular endothelial growth factor |
| Title | Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S009167490900637X https://www.clinicalkey.es/playcontent/1-s2.0-S009167490900637X https://dx.doi.org/10.1016/j.jaci.2009.03.049 https://www.ncbi.nlm.nih.gov/pubmed/19481790 https://www.proquest.com/docview/1504814321 https://www.proquest.com/docview/67427746 https://www.proquest.com/docview/876238897 |
| Volume | 124 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhhVIope-6Tbc69FacyJb80HEJDduW5NTA3oRkS61DYi-2l9BLf3tnLNtLaJJCTwZZsqXRaGYkzXxDyEcNWjGxNg6F0zoUuWShMdaFuStEEZdS68E35_QsXZ2Lr-tkvUeOp1gYdKscZb-X6YO0HkuORmoebaoKY3wlutBLJlHPZmuMYBcZ4ucf_t65eUieexNYRiHWHgNnvI_XhS6qEbOSHzLE07xdOT3e6A5I5nyui7uN0UEpnTwlT0Zrki59h5-RPVs_Jw9Px_vyF-THsmqv9S_a2iHjDagpWtW02xo8fekoHsJS-LttLdVd__NK-6KmHZ7NtqeFB8-lGzxXA46oe6qr1l0217QxM_jsS3J-8vn78SocUyuEBWxJ-hDEnLSl5alLuTaSWQMzxnQiDGgnbqRxOnJRyXVSgAFR6jKSwtkUbJ0ozzFVxiuyXze1fUNobuNYlrBrK0stIitMwlIt4ihlruQujwISTTRVxYg7jukvLtXkYHahcB4wIaZUjCuYh4B8mttsPOrGvbX5NFVqiicFCahAKdzbKrutle3GRdypSHWxYuovRgtIMre8wav__OPiBh_NQwNiSfx6QA4mxlK7XiQI6SN4DJT8ML8GIYA3O7q2zbZT0LsY7Pg0IPSOGqj0eJ7LLCCvPcfuCIuAPZlkb_9zWO_II3_Fhj7MB2QfWM--B0utN4thKS7Ig-WXb6uzPxQJPkg |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9sgEEddK22Tpmnf89a1POxt8goGO-Yxqlala5OnVsobAhs2V50d2Y6q_fc7DE5Ure2kPVnCnA3HcXfA8TuEPiuwiqkxScytUjHPBYm1NjbObcGLpBRKDbE580U2u-Tfl-lyBx2Pd2FcWGXQ_V6nD9o6lBwFbh6tqsrd8RUuhF4Q4ezsZPkI7Tl0KhD2venp2Wyxxd5lufeCBY0dQbg748O8rlRRBdhK9pU4SM277dOzleqAa9anu7jfHx3s0skL9Dw4lHjq2_wS7Zj6FXo8D0fmr9GPadXeqN-4NUPSG7BUuKpxt9ZuA6bDbh8Ww99Na7Dq-p-_lC9q2uHZrHtcePxcvHJbayAUdY9V1drr5gY3eoM_-wZdnny7OJ7FIbtCXMCqpI9B0wlTGpbZjCktiNEwaESlXIOBYlpoq6ilJVNpAT5EqUoquDUZuDs0z122jLdot25q8x7h3CSJKGHhVpaKU8N1SjLFE5oRWzKb0wjRkaeyCNDjLgPGtRxjzK6kGweXE1NIwiSMQ4S-bGhWHnjjwdpsHCo5XikFJSjBLjxINbmLynRhHneSyi6RRP4laxFKN5S3xPWffzy4JUebrgGzhPt6hPZHwZLbVqQO1YezBDh5uHkNesAd7qjaNOtOQusScOWzCOF7aji7x_JcTCL0zkvslrEOs2ciyIf_7NYhejK7mJ_L89PF2Uf01J-4uZDmfbQLYmg-gePW64MwMf8A2qFA-Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Airway+remodeling+in+subjects+with+severe+asthma+with+or+without+chronic+persistent+airflow+obstruction&rft.jtitle=Journal+of+allergy+and+clinical+immunology&rft.au=KAMINSKA%2C+Marta&rft.au=FOLEY%2C+Susan&rft.au=MARTIN%2C+James&rft.au=MAGHNI%2C+Karim&rft.date=2009-07-01&rft.pub=Elsevier&rft.issn=0091-6749&rft.volume=124&rft.issue=1&rft.spage=45&rft.epage=51&rft_id=info:doi/10.1016%2Fj.jaci.2009.03.049&rft.externalDBID=n%2Fa&rft.externalDocID=21699090 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00916749%2FS0091674909X00084%2Fcov150h.gif |