Cognitive and Cerebral Metabolic Effects of Celecoxib Versus Placebo in People With Age-Related Memory Loss: Randomized Controlled Study

• Published in: The American journal of geriatric psychiatry Vol. 16; no. 12; pp. 999 - 1009
• Main Authors: Small, Gary W., Siddarth, Prabha, Silverman, Daniel H.S., Ercoli, Linda M., Miller, Karen J., Lavretsky, Helen, Bookheimer, Susan Y., Huang, S-C, Barrio, Jorge R., Phelps, Michael E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.12.2008; Elsevier Limited
• Subjects: Adult; Age Factors; age-related memory complaints; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Apolipoprotein E4 - genetics; Apolipoprotein E4 - metabolism; Celecoxib; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cognition Disorders - drug therapy; Cognition Disorders - metabolism; Cyclooxygenase 2 Inhibitors - metabolism; Cyclooxygenase 2 Inhibitors - pharmacology; Cyclooxygenase 2 Inhibitors - therapeutic use; Cyclooxygenase-2 inhibitor; Double-Blind Method; Female; Fluorodeoxyglucose F18 - metabolism; Fluorodeoxyglucose F18 - pharmacology; Humans; Internal Medicine; Male; Memory Disorders - drug therapy; Memory Disorders - metabolism; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Pyrazoles - administration & dosage; Pyrazoles - adverse effects; Pyrazoles - therapeutic use; Radiopharmaceuticals; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - therapeutic use; Treatment Outcome; Cyclooxygenase-2 inhibitor; age-related memory complaints; positron emission tomography; celecoxib

Because anti-inflammatory drugs may delay cognitive decline and influence brain metabolism in normal aging, the authors determined the effects of the cyclooxygenase-2 inhibitor, celecoxib, on cognitive performance and regional cerebral glucose metabolism in nondemented volunteers with mild age-relat...