Cognitive and Cerebral Metabolic Effects of Celecoxib Versus Placebo in People With Age-Related Memory Loss: Randomized Controlled Study - Small, Gary W.; Siddarth, Prabha; Silverman, Daniel H.S.; Ercoli, Linda M.; Miller, Karen J.; Lavretsky, Helen; Bookheimer, Susan Y.; Huang, S-C; Barrio, Jorge R.; Phelps, Michael E. (The American journal of geriatric psychiatry, 2008)
Keywords: Adult; Age Factors; age-related memory complaints; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Apolipoprotein E4 - genetics; Apolipoprotein E4 - metabolism; Celecoxib; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cognition Disorders - drug therapy; Cognition Disorders - metabolism; Cyclooxygenase 2 Inhibitors - metabolism; Cyclooxygenase 2 Inhibitors - pharmacology; Cyclooxygenase 2 Inhibitors - therapeutic use; Cyclooxygenase-2 inhibitor; Double-Blind Method; Female; Fluorodeoxyglucose F18 - metabolism; Fluorodeoxyglucose F18 - pharmacology; Humans; Internal Medicine; Male; Memory Disorders - drug therapy; Memory Disorders - metabolism; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Pyrazoles - administration & dosage; Pyrazoles - adverse effects; Pyrazoles - therapeutic use; Radiopharmaceuticals; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - therapeutic use; Treatment Outcome; Cyclooxygenase-2 inhibitor; age-related memory complaints; positron emission tomography; celecoxib