Suppression of HIV-specific T cell activity by lymph node CD25⁺ regulatory T cells from HIV-infected individuals

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 104; no. 9; pp. 3390 - 3395
• Main Authors: Kinter, Audrey, McNally, Jonathan, Riggin, Lindsey, Jackson, Robert, Roby, Gregg, Fauci, Anthony S
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.02.2007; National Acad Sciences
• Subjects: AIDS; Biological Sciences; Blood; CD4-positive T-lymphocytes; Cell Proliferation; Cells; Cultured cells; Cytokines; disease course; Disease Progression; HIV; HIV infections; HIV Infections - immunology; Human immunodeficiency virus; Humans; immune response; Lymph nodes; Lymph Nodes - cytology; Lymphatic system; Lymphocyte receptors; Lymphoid tissue; patients; T cell receptors; T lymphocytes; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - virology; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Cytotoxic - virology; T-Lymphocytes, Regulatory - immunology; Viral load; Viremia

CD25⁺ CD4⁺ FoxP3⁺ regulatory T (Treg) cells isolated from the peripheral blood of asymptomatic HIV-infected individuals have been demonstrated to significantly suppress HIV-specific immune responses in vitro. CD25⁺ Treg cell suppressor activity in the peripheral blood seems to diminish with progress...