Construction of circRNA-Mediated Immune-Related ceRNA Network and Identification of Circulating circRNAs as Diagnostic Biomarkers in Acute Ischemic Stroke

• Published in: Journal of inflammation research Vol. 15; pp. 4087 - 4104
• Main Authors: Wang, Xing-Zhi, Li, Shuo, Liu, Yun, Cui, Gui-Yun, Yan, Fu-Ling
• Format: Journal Article
• Language: English
• Published: Macclesfield Dove Medical Press Limited 01.01.2022; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: acute ischemic stroke; Bioinformatics; Biological markers; biomarker; Biomarkers; circular rna; competing endogenous rna; Cytokines; Datasets; Disease; Gene expression; Genes; Health care; immune mechanism; Inflammation; Ischemia; Magnetic resonance imaging; Medical diagnosis; Medical imaging; Medical research; Medicine, Experimental; MicroRNA; MicroRNAs; Neuroimaging; Original Research; Plasma levels; Polymerase chain reaction; Proteins; Risk factors; Somatotropin; Stroke; Stroke (Disease); Transient ischemic attack; China; Taiwan

Background and Purpose: Accumulating evidence suggests that circular RNAs (circRNAs) are involved in immune and inflammatory processes after acute ischemic stroke (AIS). However, the roles of circRNA-mediated competing endogenous RNA (ceRNA) in modulating immune inflammation of AIS have not yet been...