Rapid Detection of Carbapenem-Resistant Klebsiella pneumoniae Using Machine Learning and MALDI-TOF MS Platform

• Published in: Infection and drug resistance Vol. 15; pp. 3703 - 3710
• Main Authors: Wang, Jinyu, Xia, Cuiping, Wu, Yue, Tian, Xin, Zhang, Ke, Wang, Zhongxin
• Format: Journal Article
• Language: English
• Published: Macclesfield Dove Medical Press Limited 01.01.2022; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Accuracy; Algorithms; Antibiotics; Antimicrobial agents; Bacterial pneumonia; Classification; Data processing; Drug resistance; Feature selection; Imipenem; Ionization; Ions; Klebsiella pneumoniae; Learning algorithms; Machine learning; maldi-tof ms; Mass spectrometry; Mass spectroscopy; Original Research; Pneumonia; Scientific imaging; Software; Support vector machines; svm; svm-k; China; France

Background: Rapid detection of carbapenem-resistant Klebsiella pneumoniae (CRKP) is essential for specific antimicrobial therapy. Machine learning techniques combined with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used as a rapid, reliable, se...