Mesenchymal stromal cells in human immunodeficiency virus‐infected patients with discordant immune response: Early results of a phase I/II clinical trial

• Published in: Stem cells translational medicine Vol. 10; no. 4; pp. 534 - 541
• Main Authors: Trujillo‐Rodríguez, María, Viciana, Pompeyo, Rivas‐Jeremías, Inmaculada, Álvarez‐Ríos, Ana I., Ruiz‐García, Antonio, Espinosa‐Ibáñez, Olga, Arias‐Santiago, Salvador, Martínez‐Atienza, Juliana, Mata, Rosario, Fernández‐López, Olga, Ruiz‐Mateos, Ezequiel, Gutiérrez‐Valencia, Alicia, López‐Cortés, Luis F.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2021; Oxford University Press
• Subjects: Acquired immune deficiency syndrome; Adipose tissue; AIDS; Antiretroviral drugs; CD4 antigen; CD8 antigen; clinical trial; Clinical trials; Dendritic cells; Drug therapy; Hepatitis; HIV; HIV infection; Hospitals; Human Clinical; Human immunodeficiency virus; Immune response; immunological nonresponders; Immunology; Immunoregulation; Infections; Inflammation; Leukocytes (mononuclear); Lymphocytes; Lymphocytes T; Mesenchymal stem cells; mesenchymal stromal cells; Mesenchyme; Morbidity; Natural killer cells; Patients; Peripheral blood mononuclear cells; Phenotypes; Stromal cells; Thrombosis; clinical trial; immunological nonresponders; HIV infection; mesenchymal stromal cells

Between 15% and 30% of HIV‐infected subjects fail to increase their CD4+ T‐cell counts despite continuous viral suppression (immunological nonresponders [INRs]). These subjects have a higher morbidity and mortality rate, but there are no effective treatments to reverse this situation so far. This st...