Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial
The aim of this study was to determine the effectiveness of prune juice on chronic constipation. We conducted a double-blind, randomized, placebo-controlled trial in Japanese subjects with chronic constipation. Prune intake significantly decreased hard and lumpy stools while increasing normal stool...
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| Published in | The American journal of gastroenterology Vol. 117; no. 10; pp. 1714 - 1717 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer
01.10.2022
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-9270 1572-0241 1572-0241 |
| DOI | 10.14309/ajg.0000000000001931 |
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| Abstract | The aim of this study was to determine the effectiveness of prune juice on chronic constipation.
We conducted a double-blind, randomized, placebo-controlled trial in Japanese subjects with chronic constipation.
Prune intake significantly decreased hard and lumpy stools while increasing normal stool and not increasing loose and watery stools. Prune intake also ameliorated subjective complaints of constipation and hard stools, without alteration of flatulence, diarrhea, loose stools, or urgent need for defecation. There were no adverse events or laboratory abnormalities of liver or renal function after prune intake.
Prune juice exerted an effective and safe natural food therapy for chronic constipation. |
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| AbstractList | The aim of this study was to determine the effectiveness of prune juice on chronic constipation.INTRODUCTIONThe aim of this study was to determine the effectiveness of prune juice on chronic constipation.We conducted a double-blind, randomized, placebo-controlled trial in Japanese subjects with chronic constipation.METHODSWe conducted a double-blind, randomized, placebo-controlled trial in Japanese subjects with chronic constipation.Prune intake significantly decreased hard and lumpy stools while increasing normal stool and not increasing loose and watery stools. Prune intake also ameliorated subjective complaints of constipation and hard stools, without alteration of flatulence, diarrhea, loose stools, or urgent need for defecation. There were no adverse events or laboratory abnormalities of liver or renal function after prune intake.RESULTSPrune intake significantly decreased hard and lumpy stools while increasing normal stool and not increasing loose and watery stools. Prune intake also ameliorated subjective complaints of constipation and hard stools, without alteration of flatulence, diarrhea, loose stools, or urgent need for defecation. There were no adverse events or laboratory abnormalities of liver or renal function after prune intake.Prune juice exerted an effective and safe natural food therapy for chronic constipation.DISCUSSIONPrune juice exerted an effective and safe natural food therapy for chronic constipation. The aim of this study was to determine the effectiveness of prune juice on chronic constipation. INTRODUCTION:The aim of this study was to determine the effectiveness of prune juice on chronic constipation.METHODS:We conducted a double-blind, randomized, placebo-controlled trial in Japanese subjects with chronic constipation.RESULTS:Prune intake significantly decreased hard and lumpy stools while increasing normal stool and not increasing loose and watery stools. Prune intake also ameliorated subjective complaints of constipation and hard stools, without alteration of flatulence, diarrhea, loose stools, or urgent need for defecation. There were no adverse events or laboratory abnormalities of liver or renal function after prune intake.DISCUSSION:Prune juice exerted an effective and safe natural food therapy for chronic constipation. abstract-type="graphical"> The aim of this study was to determine the effectiveness of prune juice on chronic constipation. We conducted a double-blind, randomized, placebo-controlled trial in Japanese subjects with chronic constipation. Prune intake significantly decreased hard and lumpy stools while increasing normal stool and not increasing loose and watery stools. Prune intake also ameliorated subjective complaints of constipation and hard stools, without alteration of flatulence, diarrhea, loose stools, or urgent need for defecation. There were no adverse events or laboratory abnormalities of liver or renal function after prune intake. Prune juice exerted an effective and safe natural food therapy for chronic constipation. |
| Author | Miura, Naoki Nagata, Naoyoshi Kawai, Takashi Koyama, Taishi Yamamoto, Hirotaka Nishiura, Kengo |
| AuthorAffiliation | Department of Gastroenterological Endoscopy, Tokyo Medical University, Japan Miura Clinic, Medical Corporation Kanonkai, Osaka, Japan Department of Rehabilitation, Fujita Health University Hospital, Aichi, Japan Institute for Health Science, MIKI Corporation, Hyogo, Japan |
| AuthorAffiliation_xml | – name: Department of Rehabilitation, Fujita Health University Hospital, Aichi, Japan – name: Department of Gastroenterological Endoscopy, Tokyo Medical University, Japan – name: Miura Clinic, Medical Corporation Kanonkai, Osaka, Japan – name: Institute for Health Science, MIKI Corporation, Hyogo, Japan |
| Author_xml | – sequence: 1 givenname: Taishi surname: Koyama fullname: Koyama, Taishi organization: Institute for Health Science, MIKI Corporation, Hyogo, Japan – sequence: 2 givenname: Naoyoshi surname: Nagata fullname: Nagata, Naoyoshi organization: Department of Gastroenterological Endoscopy, Tokyo Medical University, Japan – sequence: 3 givenname: Kengo surname: Nishiura fullname: Nishiura, Kengo organization: Department of Rehabilitation, Fujita Health University Hospital, Aichi, Japan – sequence: 4 givenname: Naoki surname: Miura fullname: Miura, Naoki organization: Miura Clinic, Medical Corporation Kanonkai, Osaka, Japan – sequence: 5 givenname: Takashi surname: Kawai fullname: Kawai, Takashi organization: Department of Gastroenterological Endoscopy, Tokyo Medical University, Japan – sequence: 6 givenname: Hirotaka surname: Yamamoto fullname: Yamamoto, Hirotaka organization: Institute for Health Science, MIKI Corporation, Hyogo, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35971232$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1053/j.gastro.2016.02.031 10.1136/bmj.300.6722.439 10.1016/S0140-6736(76)92408-9 10.14309/ajg.0000000000001149 10.1016/j.nutres.2007.06.008 10.3390/medicina57111147 10.3109/00365529509101605 10.1159/000502815 10.14309/ajg.0000000000001222 10.1111/apt.12124 10.1111/bph.13632 10.1111/j.1365-2036.2011.04594.x 10.1016/0002-9343(90)90177-F |
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We conducted a double-blind, randomized, placebo-controlled... INTRODUCTION:The aim of this study was to determine the effectiveness of prune juice on chronic constipation.METHODS:We conducted a double-blind, randomized,... The aim of this study was to determine the effectiveness of prune juice on chronic constipation.INTRODUCTIONThe aim of this study was to determine the... The aim of this study was to determine the effectiveness of prune juice on chronic constipation. |
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| SubjectTerms | Brief Communication Clinical trials Constipation Constipation - drug therapy Defecation Diarrhea Diarrhea - drug therapy Dietary Fiber Double-Blind Method Feces Gastroenterology Humans Laboratories Natural & organic foods Pectins Polyphenols Quality of life Review boards Sorbitol |
| Title | Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial |
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