Saliva proteome profiling reveals potential salivary biomarkers for detection of oral cavity squamous cell carcinoma

• Published in: Proteomics (Weinheim) Vol. 15; no. 19; pp. 3394 - 3404
• Main Authors: Wu, Chih-Ching, Chu, Hao-Wei, Hsu, Chia-Wei, Chang, Kai-Ping, Liu, Hao-Ping
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.10.2015; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Biomarker; Biomarkers; Biomarkers, Tumor; Biomedicine; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - secondary; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Mouth Neoplasms - secondary; Neoplasm Metastasis; Neoplasm Staging; Oral cancer; Proteome - analysis; Resistin; Saliva - metabolism; Salivary proteome; Tandem Mass Spectrometry; Biomarker; Biomedicine; Salivary proteome; Oral cancer; Resistin

Oral cavity squamous cell carcinoma (OSCC), which is frequently associated with poor prognosis and mortality, is a leading cause of cancer‐related death worldwide. Discovery of body fluid accessible biomarkers is needed to improve OSCC screening. To this end, we profiled proteomes of saliva from the...