Saliva proteome profiling reveals potential salivary biomarkers for detection of oral cavity squamous cell carcinoma

Oral cavity squamous cell carcinoma (OSCC), which is frequently associated with poor prognosis and mortality, is a leading cause of cancer‐related death worldwide. Discovery of body fluid accessible biomarkers is needed to improve OSCC screening. To this end, we profiled proteomes of saliva from the...

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Published inProteomics (Weinheim) Vol. 15; no. 19; pp. 3394 - 3404
Main Authors Wu, Chih-Ching, Chu, Hao-Wei, Hsu, Chia-Wei, Chang, Kai-Ping, Liu, Hao-Ping
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 01.10.2015
Wiley Subscription Services, Inc
Subjects
Adult
Aged
Biomarker
Biomarkers
Biomarkers, Tumor
Biomedicine
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Chromatography, Liquid
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Mouth Neoplasms - secondary
Neoplasm Metastasis
Neoplasm Staging
Oral cancer
Proteome - analysis
Resistin
Saliva - metabolism
Salivary proteome
Tandem Mass Spectrometry
Biomarker
Biomedicine
Salivary proteome
Oral cancer
Resistin
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Abstract Oral cavity squamous cell carcinoma (OSCC), which is frequently associated with poor prognosis and mortality, is a leading cause of cancer‐related death worldwide. Discovery of body fluid accessible biomarkers is needed to improve OSCC screening. To this end, we profiled proteomes of saliva from the healthy volunteers, the individuals with oral potentially malignant disorders (OPMD), and the OSCC patients by means of SDS‐PAGE coupled with LC‐MS/MS. In the control, the OPMD, and the OSCC groups, 958, 845, and 1030 salivary proteins were detected, respectively. With spectral counting‐based label‐free quantification, 22 overexpressed salivary proteins were identified in the OSCC group compared with the healthy controls and the OPMD individuals. Among them, resistin (RETN) was subjected to further validation with an independent cohort using ELISA. The data confirmed that the salivary RETN levels in the OSCC patients were significantly higher than that in the healthy or in the OPMD group. Moreover, the elevated levels of salivary RETN were highly correlated with late‐stage primary tumors, advanced overall stage, and lymph‐node metastasis. Our results not only reveal that profiling of saliva proteome is feasible for discovery of OSCC biomarkers, but also identify RETN as a potential salivary biomarker for OSCC detection.
AbstractList Oral cavity squamous cell carcinoma (OSCC), which is frequently associated with poor prognosis and mortality, is a leading cause of cancer‐related death worldwide. Discovery of body fluid accessible biomarkers is needed to improve OSCC screening. To this end, we profiled proteomes of saliva from the healthy volunteers, the individuals with oral potentially malignant disorders (OPMD), and the OSCC patients by means of SDS‐PAGE coupled with LC‐MS/MS. In the control, the OPMD, and the OSCC groups, 958, 845, and 1030 salivary proteins were detected, respectively. With spectral counting‐based label‐free quantification, 22 overexpressed salivary proteins were identified in the OSCC group compared with the healthy controls and the OPMD individuals. Among them, resistin (RETN) was subjected to further validation with an independent cohort using ELISA. The data confirmed that the salivary RETN levels in the OSCC patients were significantly higher than that in the healthy or in the OPMD group. Moreover, the elevated levels of salivary RETN were highly correlated with late‐stage primary tumors, advanced overall stage, and lymph‐node metastasis. Our results not only reveal that profiling of saliva proteome is feasible for discovery of OSCC biomarkers, but also identify RETN as a potential salivary biomarker for OSCC detection.
Author Chang, Kai-Ping
Chu, Hao-Wei
Wu, Chih-Ching
Hsu, Chia-Wei
Liu, Hao-Ping
Author_xml – sequence: 1
  givenname: Chih-Ching
  surname: Wu
  fullname: Wu, Chih-Ching
  organization: Department of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan
– sequence: 2
  givenname: Hao-Wei
  surname: Chu
  fullname: Chu, Hao-Wei
  organization: Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
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  givenname: Chia-Wei
  surname: Hsu
  fullname: Hsu, Chia-Wei
  organization: Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
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  givenname: Kai-Ping
  surname: Chang
  fullname: Chang, Kai-Ping
  email: : Dr. Hao-Ping Liu, Department of Veterinary Medicine, National Chung Hsing University, No. 250, Guoguang Rd., South Dist., Taichung 402, Taiwan: Additional corresponding author: Dr. Kai-Ping Chang,, hpliu@dragon.nchu.edu.twdr.kpchang@gmail.com
  organization: Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan
– sequence: 5
  givenname: Hao-Ping
  surname: Liu
  fullname: Liu, Hao-Ping
  email: : Dr. Hao-Ping Liu, Department of Veterinary Medicine, National Chung Hsing University, No. 250, Guoguang Rd., South Dist., Taichung 402, Taiwan: Additional corresponding author: Dr. Kai-Ping Chang,, hpliu@dragon.nchu.edu.twdr.kpchang@gmail.com
  organization: Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26205615$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1007/s00432-009-0657-6
10.1155/2014/619649
10.1089/omi.2013.0064
10.1093/nar/gku1003
10.1073/pnas.1311249111
10.1021/pr4012377
10.1016/j.cca.2014.08.037
10.1016/j.oraloncology.2013.05.006
10.1074/mcp.M900398-MCP200
10.1186/1471-2407-9-260
10.1158/1055-9965.EPI-13-1269
10.1111/j.1349-7006.2008.00863.x
10.1021/pr500038k
10.1021/pr2004133
10.1007/s40496-014-0014-y
10.3322/caac.21254
10.1158/1078-0432.CCR-07-5037
10.1016/j.jprot.2011.02.023
10.1155/2013/983568
10.1111/j.1349-7006.2010.01518.x
10.1016/j.bbalip.2013.02.010
10.1074/mcp.M114.045914
10.1002/pmic.200701034
10.1016/j.ctrv.2013.06.005
10.1016/j.oraloncology.2010.01.008
10.1007/s00535-009-0063-5
10.1016/j.cca.2011.02.002
10.1016/j.oraloncology.2012.08.002
10.1002/path.1640
10.5005/jcdp-6-4-1
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Salivary proteome
Oral cancer
Resistin
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References Chen, C. D., Wang, C. L., Yu, C. J., Chien, K. Y. et al., Targeted proteomics pipeline reveals potential biomarkers for the diagnosis of metastatic lung cancer in pleural effusion. J. Proteome Res. 2014, 13, 2818-2829.
Chen, Y. J., Chang, J. T., Liao, C. T., Wang, H. M. et al., Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci. 2008, 99, 1507-1514.
Bsoul, S. A., Huber, M. A., Terezhalmy, G. T., Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers. J. Contemp. Dent. Pract. 2005, 6, 1-16.
Ho, P. S., Chen, P. L., Warnakulasuriya, S., Shieh, T. Y. et al., Malignant transformation of oral potentially malignant disorders in males: a retrospective cohort study. BMC Cancer 2009, 9, 260.
Chen, Y. J., Lin, S. C., Kao, T., Chang, C. S. et al., Genome-wide profiling of oral squamous cell carcinoma. J. Pathol. 2004, 204, 326-332.
Cuevas-Cordoba, B., Santiago-Garcia, J., Saliva: a fluid of study for OMICS. OMICS 2014, 18, 87-97.
Wu, C. C., Hsu, C. W., Chen, C. D., Yu, C. J. et al., Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. Mol. Cell. Proteomics 2010, 9, 1100-1117.
Nakajima, T. E., Yamada, Y., Hamano, T., Furuta, K. et al., Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer. J. Gastroenterol. 2009, 44, 685-690.
Ghazali, N., Shaw, R. J., Rogers, S. N., Risk, J. M., Genomic determinants of normal tissue toxicity after radiotherapy for head and neck malignancy: a systematic review. Oral Oncol. 2012, 48, 1090-1100.
Hu, S., Arellano, M., Boontheung, P., Wang, J. et al., Salivary proteomics for oral cancer biomarker discovery. Clin. Cancer. Res. 2008, 14, 6246-6252.
Szklarczyk, D., Franceschini, A., Wyder, S., Forslund, K. et al., STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015, 43, D447-D452.
Liu, P. J., Chen, C. D., Wang, C. L., Wu, Y. C. et al., In-depth proteomic analysis of six types of exudative pleural effusions for nonsmall cell lung cancer biomarker discovery. Mol. Cell. Proteomics 2015, 14, 917-932.
Hsu, C. W., Yu, J. S., Peng, P. H., Liu, S. C. et al., Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma. J. Proteome Res. 2014, 13, 4796-4807.
Cancer registration system annual report 2013. Department of Statistics, Ministry of Health and Welfare, Executive Yuan, Taiwan (http://www.mohw.gov.tw/EN/Ministry/Index.aspx).
Wang, H. J., Hsieh, Y. J., Cheng, W. C., Lin, C. P. et al., JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1alpha-mediated glucose metabolism. Proc. Natl. Acad. Sci. USA 2014, 111, 279-284.
Wang, Q., Yu, Q., Lin, Q., Duan, Y., Emerging salivary biomarkers by mass spectrometry. Clin. Chim. Acta 2015, 438, 214-221.
Wu, C. C., Chang, Y. T., Chang, K. P., Liu, Y. L. et al., Salivary auto-antibodies as noninvasive diagnostic markers of oral cavity squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev. 2014, 23, 1569-1578.
Siegel, R. L., Miller, K. D., Jemal, A., Cancer statistics, 2015. CA Cancer J. Clin. 2015, 65, 5-29.
Yu, C. J., Chang, K. P., Chang, Y. J., Hsu, C. W. et al., Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using omics-based analysis. J. Proteome Res. 2011, 10, 3778-3788.
Nakajima, T. E., Yamada, Y., Hamano, T., Furuta, K. et al., Adipocytokines as new promising markers of colorectal tumors: adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer. Cancer Sci. 2010, 101, 1286-1291.
Wu, C. C., Peng, P. H., Chang, Y. T., Huang, Y. S. et al., Identification of potential serum markers for nasopharyngeal carcinoma from a xenografted mouse model using Cy-dye labeling combined with three-dimensional fractionation. Proteomics 2008, 8, 3605-3620.
Li, Y. F., Sung, F. C., Tsai, M. H., Hua, C. H. et al., Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes: the risk of oral leukoplakia. Dis. Markers 2013, 34, 247-255.
Nieman, K. M., Romero, I. L., VanHouten, B., Lengyel, E., Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim. Biophys. Acta 2013, 1831, 1533-1541.
Liu, S. Y., Lu, C. L., Chiou, C. T., Yen, C. Y. et al., Surgical outcomes and prognostic factors of oral cancer associated with betel quid chewing and tobacco smoking in Taiwan. Oral Oncol. 2010, 46, 276-282.
Chang, K. P., Wu, C. C., Fang, K. H., Tsai, C. Y. et al., Serum levels of chemokine (C-X-C motif) ligand 9 (CXCL9) are associated with tumor progression and treatment outcome in patients with oral cavity squamous cell carcinoma. Oral Oncol. 2013, 49, 802-807.
Chang, K. P., Chang, Y. T., Liao, C. T., Yen, T. C. et al., Prognostic cytokine markers in peripheral blood for oral cavity squamous cell carcinoma identified by multiplexed immunobead-based profiling. Clin. Chim. Acta 2011, 412, 980-987.
Nakajima, T. E., Yamada, Y., Hamano, T., Furuta, K. et al., Adipocytokines and squamous cell carcinoma of the esophagus. J. Cancer Res. Clin. Oncol. 2010, 136, 261-266.
Diakowska, D., Markocka-Maczka, K., Szelachowski, P., Grabowski, K., Serum levels of resistin, adiponectin, and apelin in gastroesophageal cancer patients. Dis. Markers 2014, 2014, 619649.
Yakob, M., Fuentes, L., Wang, M. B., Abemayor, E., Wong, D. T., Salivary biomarkers for detection of oral squamous cell carcinoma - current state and recent advances. Curr. Oral Health Rep. 2014, 1, 133-141.
Peng, P. H., Wu, C. C., Liu, S. C., Chang, K. P. et al., Quantitative plasma proteome analysis reveals aberrant level of blood coagulation-related proteins in nasopharyngeal carcinoma. J. Proteomics 2011, 74, 744-757.
Ntikoudi, E., Kiagia, M., Boura, P., Syrigos, K. N., Hormones of adipose tissue and their biologic role in lung cancer. Cancer Treat. Rev. 2014, 40, 22-30.
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References_xml – reference: Yakob, M., Fuentes, L., Wang, M. B., Abemayor, E., Wong, D. T., Salivary biomarkers for detection of oral squamous cell carcinoma - current state and recent advances. Curr. Oral Health Rep. 2014, 1, 133-141.
– reference: Nakajima, T. E., Yamada, Y., Hamano, T., Furuta, K. et al., Adipocytokines as new promising markers of colorectal tumors: adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer. Cancer Sci. 2010, 101, 1286-1291.
– reference: Hu, S., Arellano, M., Boontheung, P., Wang, J. et al., Salivary proteomics for oral cancer biomarker discovery. Clin. Cancer. Res. 2008, 14, 6246-6252.
– reference: Siegel, R. L., Miller, K. D., Jemal, A., Cancer statistics, 2015. CA Cancer J. Clin. 2015, 65, 5-29.
– reference: Cancer registration system annual report 2013. Department of Statistics, Ministry of Health and Welfare, Executive Yuan, Taiwan (http://www.mohw.gov.tw/EN/Ministry/Index.aspx).
– reference: Ho, P. S., Chen, P. L., Warnakulasuriya, S., Shieh, T. Y. et al., Malignant transformation of oral potentially malignant disorders in males: a retrospective cohort study. BMC Cancer 2009, 9, 260.
– reference: Chang, K. P., Chang, Y. T., Liao, C. T., Yen, T. C. et al., Prognostic cytokine markers in peripheral blood for oral cavity squamous cell carcinoma identified by multiplexed immunobead-based profiling. Clin. Chim. Acta 2011, 412, 980-987.
– reference: Wang, Q., Yu, Q., Lin, Q., Duan, Y., Emerging salivary biomarkers by mass spectrometry. Clin. Chim. Acta 2015, 438, 214-221.
– reference: Li, Y. F., Sung, F. C., Tsai, M. H., Hua, C. H. et al., Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes: the risk of oral leukoplakia. Dis. Markers 2013, 34, 247-255.
– reference: Bsoul, S. A., Huber, M. A., Terezhalmy, G. T., Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers. J. Contemp. Dent. Pract. 2005, 6, 1-16.
– reference: Ntikoudi, E., Kiagia, M., Boura, P., Syrigos, K. N., Hormones of adipose tissue and their biologic role in lung cancer. Cancer Treat. Rev. 2014, 40, 22-30.
– reference: Nakajima, T. E., Yamada, Y., Hamano, T., Furuta, K. et al., Adipocytokines and squamous cell carcinoma of the esophagus. J. Cancer Res. Clin. Oncol. 2010, 136, 261-266.
– reference: Wu, C. C., Chang, Y. T., Chang, K. P., Liu, Y. L. et al., Salivary auto-antibodies as noninvasive diagnostic markers of oral cavity squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev. 2014, 23, 1569-1578.
– reference: Wang, H. J., Hsieh, Y. J., Cheng, W. C., Lin, C. P. et al., JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1alpha-mediated glucose metabolism. Proc. Natl. Acad. Sci. USA 2014, 111, 279-284.
– reference: Chang, K. P., Wu, C. C., Fang, K. H., Tsai, C. Y. et al., Serum levels of chemokine (C-X-C motif) ligand 9 (CXCL9) are associated with tumor progression and treatment outcome in patients with oral cavity squamous cell carcinoma. Oral Oncol. 2013, 49, 802-807.
– reference: Yu, C. J., Chang, K. P., Chang, Y. J., Hsu, C. W. et al., Identification of guanylate-binding protein 1 as a potential oral cancer marker involved in cell invasion using omics-based analysis. J. Proteome Res. 2011, 10, 3778-3788.
– reference: Cuevas-Cordoba, B., Santiago-Garcia, J., Saliva: a fluid of study for OMICS. OMICS 2014, 18, 87-97.
– reference: Liu, P. J., Chen, C. D., Wang, C. L., Wu, Y. C. et al., In-depth proteomic analysis of six types of exudative pleural effusions for nonsmall cell lung cancer biomarker discovery. Mol. Cell. Proteomics 2015, 14, 917-932.
– reference: Chen, C. D., Wang, C. L., Yu, C. J., Chien, K. Y. et al., Targeted proteomics pipeline reveals potential biomarkers for the diagnosis of metastatic lung cancer in pleural effusion. J. Proteome Res. 2014, 13, 2818-2829.
– reference: Chen, Y. J., Chang, J. T., Liao, C. T., Wang, H. M. et al., Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci. 2008, 99, 1507-1514.
– reference: Wu, C. C., Peng, P. H., Chang, Y. T., Huang, Y. S. et al., Identification of potential serum markers for nasopharyngeal carcinoma from a xenografted mouse model using Cy-dye labeling combined with three-dimensional fractionation. Proteomics 2008, 8, 3605-3620.
– reference: Wu, C. C., Hsu, C. W., Chen, C. D., Yu, C. J. et al., Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas. Mol. Cell. Proteomics 2010, 9, 1100-1117.
– reference: Nakajima, T. E., Yamada, Y., Hamano, T., Furuta, K. et al., Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer. J. Gastroenterol. 2009, 44, 685-690.
– reference: Szklarczyk, D., Franceschini, A., Wyder, S., Forslund, K. et al., STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015, 43, D447-D452.
– reference: Peng, P. H., Wu, C. C., Liu, S. C., Chang, K. P. et al., Quantitative plasma proteome analysis reveals aberrant level of blood coagulation-related proteins in nasopharyngeal carcinoma. J. Proteomics 2011, 74, 744-757.
– reference: Ghazali, N., Shaw, R. J., Rogers, S. N., Risk, J. M., Genomic determinants of normal tissue toxicity after radiotherapy for head and neck malignancy: a systematic review. Oral Oncol. 2012, 48, 1090-1100.
– reference: Diakowska, D., Markocka-Maczka, K., Szelachowski, P., Grabowski, K., Serum levels of resistin, adiponectin, and apelin in gastroesophageal cancer patients. Dis. Markers 2014, 2014, 619649.
– reference: Hsu, C. W., Yu, J. S., Peng, P. H., Liu, S. C. et al., Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma. J. Proteome Res. 2014, 13, 4796-4807.
– reference: Liu, S. Y., Lu, C. L., Chiou, C. T., Yen, C. Y. et al., Surgical outcomes and prognostic factors of oral cancer associated with betel quid chewing and tobacco smoking in Taiwan. Oral Oncol. 2010, 46, 276-282.
– reference: Chen, Y. J., Lin, S. C., Kao, T., Chang, C. S. et al., Genome-wide profiling of oral squamous cell carcinoma. J. Pathol. 2004, 204, 326-332.
– reference: Nieman, K. M., Romero, I. L., VanHouten, B., Lengyel, E., Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim. Biophys. Acta 2013, 1831, 1533-1541.
– volume: 49
  start-page: 802
  year: 2013
  end-page: 807
  article-title: Serum levels of chemokine (C‐X‐C motif) ligand 9 (CXCL9) are associated with tumor progression and treatment outcome in patients with oral cavity squamous cell carcinoma
  publication-title: Oral Oncol
– volume: 438
  start-page: 214
  year: 2015
  end-page: 221
  article-title: Emerging salivary biomarkers by mass spectrometry
  publication-title: Clin. Chim. Acta
– volume: 9
  start-page: 1100
  year: 2010
  end-page: 1117
  article-title: Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas
  publication-title: Mol. Cell. Proteomics
– volume: 412
  start-page: 980
  year: 2011
  end-page: 987
  article-title: Prognostic cytokine markers in peripheral blood for oral cavity squamous cell carcinoma identified by multiplexed immunobead‐based profiling
  publication-title: Clin. Chim. Acta
– volume: 204
  start-page: 326
  year: 2004
  end-page: 332
  article-title: Genome‐wide profiling of oral squamous cell carcinoma
  publication-title: J. Pathol.
– volume: 65
  start-page: 5
  year: 2015
  end-page: 29
  article-title: Cancer statistics
  publication-title: CA Cancer J. Clin.
– volume: 111
  start-page: 279
  year: 2014
  end-page: 284
  article-title: JMJD5 regulates PKM2 nuclear translocation and reprograms HIF‐1alpha‐mediated glucose metabolism
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 18
  start-page: 87
  year: 2014
  end-page: 97
  article-title: Saliva: a fluid of study for OMICS
  publication-title: OMICS
– volume: 9
  start-page: 260
  year: 2009
  article-title: Malignant transformation of oral potentially malignant disorders in males: a retrospective cohort study
  publication-title: BMC Cancer
– volume: 14
  start-page: 6246
  year: 2008
  end-page: 6252
  article-title: Salivary proteomics for oral cancer biomarker discovery
  publication-title: Clin. Cancer. Res.
– volume: 46
  start-page: 276
  year: 2010
  end-page: 282
  article-title: Surgical outcomes and prognostic factors of oral cancer associated with betel quid chewing and tobacco smoking in Taiwan
  publication-title: Oral Oncol
– volume: 74
  start-page: 744
  year: 2011
  end-page: 757
  article-title: Quantitative plasma proteome analysis reveals aberrant level of blood coagulation‐related proteins in nasopharyngeal carcinoma
  publication-title: J. Proteomics
– volume: 13
  start-page: 4796
  year: 2014
  end-page: 4807
  article-title: Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma
  publication-title: J. Proteome Res.
– volume: 136
  start-page: 261
  year: 2010
  end-page: 266
  article-title: Adipocytokines and squamous cell carcinoma of the esophagus
  publication-title: J. Cancer Res. Clin. Oncol.
– volume: 2014
  start-page: 619649
  year: 2014
  article-title: Serum levels of resistin, adiponectin, and apelin in gastroesophageal cancer patients
  publication-title: Dis. Markers
– volume: 10
  start-page: 3778
  year: 2011
  end-page: 3788
  article-title: Identification of guanylate‐binding protein 1 as a potential oral cancer marker involved in cell invasion using omics‐based analysis
  publication-title: J. Proteome Res.
– volume: 13
  start-page: 2818
  year: 2014
  end-page: 2829
  article-title: Targeted proteomics pipeline reveals potential biomarkers for the diagnosis of metastatic lung cancer in pleural effusion
  publication-title: J. Proteome Res.
– volume: 99
  start-page: 1507
  year: 2008
  end-page: 1514
  article-title: Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis
  publication-title: Cancer Sci
– volume: 44
  start-page: 685
  year: 2009
  end-page: 690
  article-title: Adipocytokine levels in gastric cancer patients: resistin and visfatin as biomarkers of gastric cancer
  publication-title: J. Gastroenterol.
– volume: 8
  start-page: 3605
  year: 2008
  end-page: 3620
  article-title: Identification of potential serum markers for nasopharyngeal carcinoma from a xenografted mouse model using Cy‐dye labeling combined with three‐dimensional fractionation
  publication-title: Proteomics
– volume: 48
  start-page: 1090
  year: 2012
  end-page: 1100
  article-title: Genomic determinants of normal tissue toxicity after radiotherapy for head and neck malignancy: a systematic review
  publication-title: Oral Oncol
– volume: 101
  start-page: 1286
  year: 2010
  end-page: 1291
  article-title: Adipocytokines as new promising markers of colorectal tumors: adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer
  publication-title: Cancer Sci
– volume: 34
  start-page: 247
  year: 2013
  end-page: 255
  article-title: Interactions between cigarette smoking and polymorphisms of xenobiotic‐metabolizing genes: the risk of oral leukoplakia
  publication-title: Dis. Markers
– volume: 14
  start-page: 917
  year: 2015
  end-page: 932
  article-title: In‐depth proteomic analysis of six types of exudative pleural effusions for nonsmall cell lung cancer biomarker discovery
  publication-title: Mol. Cell. Proteomics
– volume: 40
  start-page: 22
  year: 2014
  end-page: 30
  article-title: Hormones of adipose tissue and their biologic role in lung cancer
  publication-title: Cancer Treat. Rev.
– volume: 1831
  start-page: 1533
  year: 2013
  end-page: 1541
  article-title: Adipose tissue and adipocytes support tumorigenesis and metastasis
  publication-title: Biochim. Biophys. Acta
– volume: 1
  start-page: 133
  year: 2014
  end-page: 141
  article-title: Salivary biomarkers for detection of oral squamous cell carcinoma ‐ current state and recent advances
  publication-title: Curr. Oral Health Rep.
– volume: 6
  start-page: 1
  year: 2005
  end-page: 16
  article-title: Squamous cell carcinoma of the oral tissues: a comprehensive review for oral healthcare providers
  publication-title: J. Contemp. Dent. Pract.
– volume: 23
  start-page: 1569
  year: 2014
  end-page: 1578
  article-title: Salivary auto‐antibodies as noninvasive diagnostic markers of oral cavity squamous cell carcinoma
  publication-title: Cancer Epidemiol. Biomarkers Prev.
– volume: 43
  start-page: D447
  year: 2015
  end-page: D452
  article-title: STRING v10: protein‐protein interaction networks, integrated over the tree of life
  publication-title: Nucleic Acids Res
– year: 2013
– ident: e_1_2_8_31_1
  doi: 10.1007/s00432-009-0657-6
– ident: e_1_2_8_27_1
  doi: 10.1155/2014/619649
– ident: e_1_2_8_11_1
  doi: 10.1089/omi.2013.0064
– ident: e_1_2_8_22_1
  doi: 10.1093/nar/gku1003
– ident: e_1_2_8_23_1
  doi: 10.1073/pnas.1311249111
– ident: e_1_2_8_19_1
  doi: 10.1021/pr4012377
– ident: e_1_2_8_13_1
  doi: 10.1016/j.cca.2014.08.037
– ident: e_1_2_8_6_1
  doi: 10.1016/j.oraloncology.2013.05.006
– ident: e_1_2_8_18_1
  doi: 10.1074/mcp.M900398-MCP200
– ident: e_1_2_8_16_1
  doi: 10.1186/1471-2407-9-260
– ident: e_1_2_8_9_1
  doi: 10.1158/1055-9965.EPI-13-1269
– ident: e_1_2_8_4_1
  doi: 10.1111/j.1349-7006.2008.00863.x
– ident: e_1_2_8_20_1
  doi: 10.1021/pr500038k
– ident: e_1_2_8_7_1
  doi: 10.1021/pr2004133
– ident: e_1_2_8_10_1
  doi: 10.1007/s40496-014-0014-y
– ident: e_1_2_8_2_1
  doi: 10.3322/caac.21254
– ident: e_1_2_8_12_1
  doi: 10.1158/1078-0432.CCR-07-5037
– ident: e_1_2_8_26_1
  doi: 10.1016/j.jprot.2011.02.023
– ident: e_1_2_8_25_1
  doi: 10.1155/2013/983568
– volume-title: Department of Statistics, Ministry of Health and Welfare, Executive Yuan
  year: 2013
  ident: e_1_2_8_3_1
– ident: e_1_2_8_30_1
  doi: 10.1111/j.1349-7006.2010.01518.x
– ident: e_1_2_8_29_1
  doi: 10.1016/j.bbalip.2013.02.010
– ident: e_1_2_8_21_1
  doi: 10.1074/mcp.M114.045914
– ident: e_1_2_8_17_1
  doi: 10.1002/pmic.200701034
– ident: e_1_2_8_28_1
  doi: 10.1016/j.ctrv.2013.06.005
– ident: e_1_2_8_5_1
  doi: 10.1016/j.oraloncology.2010.01.008
– ident: e_1_2_8_32_1
  doi: 10.1007/s00535-009-0063-5
– ident: e_1_2_8_8_1
  doi: 10.1016/j.cca.2011.02.002
– ident: e_1_2_8_24_1
  doi: 10.1016/j.oraloncology.2012.08.002
– ident: e_1_2_8_15_1
  doi: 10.1002/path.1640
– ident: e_1_2_8_14_1
  doi: 10.5005/jcdp-6-4-1
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Snippet Oral cavity squamous cell carcinoma (OSCC), which is frequently associated with poor prognosis and mortality, is a leading cause of cancer‐related death...
Oral cavity squamous cell carcinoma (OSCC), which is frequently associated with poor prognosis and mortality, is a leading cause of cancer-related death...
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StartPage 3394
SubjectTerms Adult
Aged
Biomarker
Biomarkers
Biomarkers, Tumor
Biomedicine
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Chromatography, Liquid
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Mouth Neoplasms - secondary
Neoplasm Metastasis
Neoplasm Staging
Oral cancer
Proteome - analysis
Resistin
Saliva - metabolism
Salivary proteome
Tandem Mass Spectrometry
Title Saliva proteome profiling reveals potential salivary biomarkers for detection of oral cavity squamous cell carcinoma
URI https://api.istex.fr/ark:/67375/WNG-4734R47R-C/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpmic.201500157
https://www.ncbi.nlm.nih.gov/pubmed/26205615
https://www.proquest.com/docview/1719050179
https://www.proquest.com/docview/1719976860
https://www.proquest.com/docview/1727698895
Volume 15
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