Activated T follicular helper-like cells are released into blood after oral vaccination and correlate with vaccine specific mucosal B-cell memory
T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses ma...
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| Published in | Scientific reports Vol. 8; no. 1; pp. 2729 - 15 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Nature Publishing Group UK
09.02.2018
Nature Publishing Group |
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| Abstract | T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses may relate to IgA production are unknown. We investigated the frequencies, phenotype and function of circulating Tfh-like CD4
+
CXCR5
+
T cells (cTfh) in adults receiving an oral inactivated enterotoxigenic
Escherichia coli
vaccine. Subjects were classified as vaccine responders or weak/non-responders based on their intestine-derived antibody-secreting cell (ASC) IgA responses to major vaccine antigens. Oral immunization induced significantly increased proportions of cTfh cells expressing the cTfh activation marker inducible costimulator (ICOS) in ASC responders, but not in weak/non-responders. Vaccination also enhanced the expression of IL-21, Th17 markers and integrin β7 by activated cTfh cells, supporting functionality and gut homing potential. cTfh cells promoted total and vaccine specific IgA production from cocultured B cells. Magnitudes of cTfh responses assessed within a week after primary vaccinations correlated with memory intestine-derived vaccine specific IgA responses 1–2 years later. We conclude that activated ICOS
+
Tfh-like cells are mobilized into blood after oral vaccination and may be used as biomarkers of vaccine specific mucosal memory in humans. |
|---|---|
| AbstractList | T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses may relate to IgA production are unknown. We investigated the frequencies, phenotype and function of circulating Tfh-like CD4
+
CXCR5
+
T cells (cTfh) in adults receiving an oral inactivated enterotoxigenic
Escherichia coli
vaccine. Subjects were classified as vaccine responders or weak/non-responders based on their intestine-derived antibody-secreting cell (ASC) IgA responses to major vaccine antigens. Oral immunization induced significantly increased proportions of cTfh cells expressing the cTfh activation marker inducible costimulator (ICOS) in ASC responders, but not in weak/non-responders. Vaccination also enhanced the expression of IL-21, Th17 markers and integrin β7 by activated cTfh cells, supporting functionality and gut homing potential. cTfh cells promoted total and vaccine specific IgA production from cocultured B cells. Magnitudes of cTfh responses assessed within a week after primary vaccinations correlated with memory intestine-derived vaccine specific IgA responses 1–2 years later. We conclude that activated ICOS
+
Tfh-like cells are mobilized into blood after oral vaccination and may be used as biomarkers of vaccine specific mucosal memory in humans. T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses may relate to IgA production are unknown. We investigated the frequencies, phenotype and function of circulating Tfh-like CD4(+) CXCR5(+) T cells (cTfh) in adults receiving an oral inactivated enterotoxigenic Escherichia coli vaccine. Subjects were classified as vaccine responders or weak/non-responders based on their intestine-derived antibody-secreting cell (ASC) IgA responses to major vaccine antigens. Oral immunization induced significantly increased proportions of cTfh cells expressing the cTfh activation marker inducible costimulator (ICOS) in ASC responders, but not in weak/non-responders. Vaccination also enhanced the expression of IL-21, Th17 markers and integrin beta 7 by activated cTfh cells, supporting functionality and gut homing potential. cTfh cells promoted total and vaccine specific IgA production from cocultured B cells. Magnitudes of cTfh responses assessed within a week after primary vaccinations correlated with memory intestine-derived vaccine specific IgA responses 1-2 years later. We conclude that activated ICOS+ Tfh-like cells are mobilized into blood after oral vaccination and may be used as biomarkers of vaccine specific mucosal memory in humans. T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses may relate to IgA production are unknown. We investigated the frequencies, phenotype and function of circulating Tfh-like CD4 CXCR5 T cells (cTfh) in adults receiving an oral inactivated enterotoxigenic Escherichia coli vaccine. Subjects were classified as vaccine responders or weak/non-responders based on their intestine-derived antibody-secreting cell (ASC) IgA responses to major vaccine antigens. Oral immunization induced significantly increased proportions of cTfh cells expressing the cTfh activation marker inducible costimulator (ICOS) in ASC responders, but not in weak/non-responders. Vaccination also enhanced the expression of IL-21, Th17 markers and integrin β7 by activated cTfh cells, supporting functionality and gut homing potential. cTfh cells promoted total and vaccine specific IgA production from cocultured B cells. Magnitudes of cTfh responses assessed within a week after primary vaccinations correlated with memory intestine-derived vaccine specific IgA responses 1-2 years later. We conclude that activated ICOS Tfh-like cells are mobilized into blood after oral vaccination and may be used as biomarkers of vaccine specific mucosal memory in humans. T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses may relate to IgA production are unknown. We investigated the frequencies, phenotype and function of circulating Tfh-like CD4+CXCR5+ T cells (cTfh) in adults receiving an oral inactivated enterotoxigenic Escherichia coli vaccine. Subjects were classified as vaccine responders or weak/non-responders based on their intestine-derived antibody-secreting cell (ASC) IgA responses to major vaccine antigens. Oral immunization induced significantly increased proportions of cTfh cells expressing the cTfh activation marker inducible costimulator (ICOS) in ASC responders, but not in weak/non-responders. Vaccination also enhanced the expression of IL-21, Th17 markers and integrin β7 by activated cTfh cells, supporting functionality and gut homing potential. cTfh cells promoted total and vaccine specific IgA production from cocultured B cells. Magnitudes of cTfh responses assessed within a week after primary vaccinations correlated with memory intestine-derived vaccine specific IgA responses 1-2 years later. We conclude that activated ICOS+ Tfh-like cells are mobilized into blood after oral vaccination and may be used as biomarkers of vaccine specific mucosal memory in humans.T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses may relate to IgA production are unknown. We investigated the frequencies, phenotype and function of circulating Tfh-like CD4+CXCR5+ T cells (cTfh) in adults receiving an oral inactivated enterotoxigenic Escherichia coli vaccine. Subjects were classified as vaccine responders or weak/non-responders based on their intestine-derived antibody-secreting cell (ASC) IgA responses to major vaccine antigens. Oral immunization induced significantly increased proportions of cTfh cells expressing the cTfh activation marker inducible costimulator (ICOS) in ASC responders, but not in weak/non-responders. Vaccination also enhanced the expression of IL-21, Th17 markers and integrin β7 by activated cTfh cells, supporting functionality and gut homing potential. cTfh cells promoted total and vaccine specific IgA production from cocultured B cells. Magnitudes of cTfh responses assessed within a week after primary vaccinations correlated with memory intestine-derived vaccine specific IgA responses 1-2 years later. We conclude that activated ICOS+ Tfh-like cells are mobilized into blood after oral vaccination and may be used as biomarkers of vaccine specific mucosal memory in humans. T follicular helper (Tfh)-like cells with potent B-cell helping ability are mobilized into human circulation after parenteral vaccination and are generally held to reflect ongoing germinal center reactions. However, whether mucosal vaccination induces systemic Tfh responses and how such responses may relate to IgA production are unknown. We investigated the frequencies, phenotype and function of circulating Tfh-like CD4+CXCR5+ T cells (cTfh) in adults receiving an oral inactivated enterotoxigenic Escherichia coli vaccine. Subjects were classified as vaccine responders or weak/non-responders based on their intestine-derived antibody-secreting cell (ASC) IgA responses to major vaccine antigens. Oral immunization induced significantly increased proportions of cTfh cells expressing the cTfh activation marker inducible costimulator (ICOS) in ASC responders, but not in weak/non-responders. Vaccination also enhanced the expression of IL-21, Th17 markers and integrin β7 by activated cTfh cells, supporting functionality and gut homing potential. cTfh cells promoted total and vaccine specific IgA production from cocultured B cells. Magnitudes of cTfh responses assessed within a week after primary vaccinations correlated with memory intestine-derived vaccine specific IgA responses 1–2 years later. We conclude that activated ICOS+ Tfh-like cells are mobilized into blood after oral vaccination and may be used as biomarkers of vaccine specific mucosal memory in humans. |
| ArticleNumber | 2729 |
| Author | Lundgren, Anna Cárdeno, Ana Quiding-Järbrink, Marianne Magnusson, Maria K. |
| Author_xml | – sequence: 1 givenname: Ana surname: Cárdeno fullname: Cárdeno, Ana organization: Department of Microbiology and Immunology, University of Gothenburg – sequence: 2 givenname: Maria K. surname: Magnusson fullname: Magnusson, Maria K. organization: Department of Microbiology and Immunology, University of Gothenburg – sequence: 3 givenname: Marianne surname: Quiding-Järbrink fullname: Quiding-Järbrink, Marianne organization: Department of Microbiology and Immunology, University of Gothenburg – sequence: 4 givenname: Anna surname: Lundgren fullname: Lundgren, Anna email: anna.lundgren@microbio.gu.se organization: Department of Microbiology and Immunology, University of Gothenburg |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29426881$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/264700$$DView record from Swedish Publication Index |
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| Cites_doi | 10.1172/JCI115270 10.1038/nri3447 10.1002/eji.200636136 10.1038/srep27944 10.1172/JCI76861 10.1128/IAI.66.7.3311-3316.1998 10.1016/j.vaccine.2016.11.059 10.1016/j.vaccine.2005.07.022 10.4049/jimmunol.1501524 10.1016/j.immuni.2013.09.007 10.1371/journal.pone.0176641 10.1016/j.immuni.2010.12.012 10.1172/JCI119286 10.3109/08820131003680369 10.4049/jimmunol.1600320 10.1016/j.vaccine.2008.12.041 10.1016/S0022-1759(03)00226-6 10.1186/1471-2172-12-53 10.1126/scitranslmed.3000448 10.1016/j.immuni.2013.08.031 10.1128/IAI.01407-12 10.1371/journal.pone.0137195 10.1126/scitranslmed.3005191 10.1016/j.vaccine.2013.03.027 10.1098/rstb.2015.0142 10.1016/j.immuni.2015.12.011 10.1038/mi.2010.54 10.1016/j.vaccine.2013.04.066 10.1016/j.jaci.2013.01.004 10.1016/j.vaccine.2012.12.063 10.1038/nprot.2013.058 10.1371/journal.pone.0051718 10.14348/molcells.2015.2331 10.1038/srep26494 10.1038/nri3251 10.1016/j.vaccine.2014.10.069 10.1016/j.it.2014.06.002 10.1016/j.vaccine.2016.04.055 10.4049/jimmunol.158.2.574 10.1146/annurev-immunol-041015-055605 10.1038/ni.3054 10.1016/j.jaci.2015.05.036 10.1084/jem.20161794 10.1016/j.celrep.2015.09.004 10.1128/CVI.00538-10 10.1016/j.vaccine.2017.05.005 10.4049/jimmunol.1401633 10.1084/jem.20091706 10.1038/mi.2012.56 10.1016/j.coi.2015.02.010 10.1128/JVI.02077-13 10.1016/j.vaccine.2009.05.005 |
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| References | MaCSMonogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficienciesJ Allergy Clin Immunol20151369931006 e10011:CAS:528:DC%2BC2MXhtFehtb3J10.1016/j.jaci.2015.05.036261625725042203 MatsuiKCirculating CXCR5(+)CD4(+) T Follicular-Like Helper Cell and Memory B Cell Responses to Human Papillomavirus VaccinesPLoS One201510e013719510.1371/journal.pone.0137195263330704557948 LundgrenAJertbornMSvennerholmAMInduction of long term mucosal immunological memory in humans by an oral inactivated multivalent enterotoxigenic Escherichia coli vaccineVaccine201634313231401:CAS:528:DC%2BC28XnsVWntrg%3D10.1016/j.vaccine.2016.04.05527133878 Havenar-DaughtonCCytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker TechniqueJ Immunol201619799410021:CAS:528:DC%2BC28XhtFOktLvE10.4049/jimmunol.1600320273355024955744 VinuesaCGLintermanMAYuDMacLennanICFollicular Helper T CellsAnnu Rev Immunol2016343353681:CAS:528:DC%2BC28XivFKlsrw%3D10.1146/annurev-immunol-041015-05560526907215 HeJCirculating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposureImmunity2013397707811:CAS:528:DC%2BC3sXhs1eqtLjJ10.1016/j.immuni.2013.09.00724138884 LarenaMHolmgrenJLebensMTerrinoniMLundgrenACholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signalingJ Immunol2015194382938391:CAS:528:DC%2BC2MXlvVejur4%3D10.4049/jimmunol.140163325786687 PaulosCMThe inducible costimulator (ICOS) is critical for the development of human T(H)17 cellsSci Transl Med2010255ra7810.1126/scitranslmed.300044820980695 AlamSKnowldenZASangsterMYSantAJCD4 T cell help is limiting and selective during the primary B cell response to influenza virus infectionJ Virol20148831432410.1128/JVI.02077-13241553793911719 Sjokvist OttsjoLFlachCFClementsJHolmgrenJRaghavanSA double mutant heat-labile toxin from Escherichia coli, LT(R192G/L211A), is an effective mucosal adjuvant for vaccination against Helicobacter pylori infectionInfect Immun2013811532154010.1128/IAI.01407-12234393053647992 BentebibelSEInduction of ICOS+ CXCR3+ CXCR5+ TH cells correlates with antibody responses to influenza vaccinationSci Transl Med20135176ra13210.1126/scitranslmed.3005191 SalettiGCuburuNYangJSDeyACzerkinskyCEnzyme-linked immunospot assays for direct ex vivo measurement of vaccine-induced human humoral immune responses in bloodNat Protoc201381073108710.1038/nprot.2013.05823660756 AveryDTB cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humansJ Exp Med20102071551711:CAS:528:DC%2BC3cXht1ekt78%3D10.1084/jem.20091706200482852812540 Quiding-JarbrinkMDifferential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responsesJ Clin Invest199799128112861:CAS:528:DyaK2sXhvFyhsLo%3D10.1172/JCI1192869077537507943 Czerkinsky, C. & Holmgren, J. Vaccines against enteric infections for the developing world. Philos Trans R Soc Lond B Biol Sci370, https://doi.org/10.1098/rstb.2015.0142 (2015). HolmgrenJCorrelates of protection for enteric vaccinesVaccine201735335533631:CAS:528:DC%2BC2sXnvFCqtLY%3D10.1016/j.vaccine.2017.05.00528504192 RasheedAURahnHPSallustoFLippMMullerGFollicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expressionEur J Immunol200636189219031:CAS:528:DC%2BD28XnslOms74%3D10.1002/eji.20063613616791882 TangyeSGMaCSBrinkRDeenickEKThe good, the bad and the ugly - TFH cells in human health and diseaseNat Rev Immunol2013134124261:CAS:528:DC%2BC3sXnslansL0%3D10.1038/nri344723681096 LeachSLundgrenASvennerholmAMDifferent kinetics of circulating antibody-secreting cell responses after primary and booster oral immunizations: a tool for assessing immunological memoryVaccine201331303530381:CAS:528:DC%2BC3sXosVOntbk%3D10.1016/j.vaccine.2013.04.06623664997 CubasRReversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV InfectionJ Immunol2015195562556361:CAS:528:DC%2BC2MXhvFGnt73N10.4049/jimmunol.1501524265466094670798 RombergNGain-of-function STAT1 mutations are associated with PD-L1 overexpression and a defect in B-cell survivalJ Allergy Clin Immunol2013131169116931:CAS:528:DC%2BC3sXisVGmtbY%3D10.1016/j.jaci.2013.01.004234030483672340 NortonEBLawsonLBFreytagLCClementsJDCharacterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvantClin Vaccine Immunol2011185465511:CAS:528:DC%2BC3MXkvVaisbo%3D10.1128/CVI.00538-10212889943122563 BergqvistPRe-utilization of germinal centers in multiple Peyer’s patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responsesMucosal Immunol201361221351:CAS:528:DC%2BC38XhtVSgtLvI10.1038/mi.2012.5622785230 WangCHillsamerPKimCHPhenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsetsBMC Immunol201112531:CAS:528:DC%2BC3MXhtlGqsLjJ10.1186/1471-2172-12-53219141883184275 LocciMHuman circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responsesImmunity2013397587691:CAS:528:DC%2BC3sXhsVertbjL10.1016/j.immuni.2013.08.031240353653996844 Obeng-AdjeiNCirculating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in ChildrenCell Rep2015134254391:CAS:528:DC%2BC2MXhs1SqsLrN10.1016/j.celrep.2015.09.004264408974607674 BrandtzaegPFunction of mucosa-associated lymphoid tissue in antibody formationImmunol Invest2010393033551:CAS:528:DC%2BC3cXlslegtbk%3D10.3109/0882013100368036920450282 QuidingMIntestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memoryJ Clin Invest1991881431481:CAS:528:DyaK3MXltFags7w%3D10.1172/JCI1152701905327296014 LyckeNRecent progress in mucosal vaccine development: potential and limitationsNature Reviews Immunology2012125926051:CAS:528:DC%2BC38XhtV2itbjM10.1038/nri325122828912 Carpenter, C. M. et al. Comparison of the antibody in lymphocyte supernatant (ALS) and ELISPOT assays for detection of mucosal immune responses to antigens of enterotoxigenic Escherichia coli in challenged and vaccinated volunteers. Vaccine24, 3709–3718, https://doi.org/10.1016/j.vaccine.2005.07.022 (2006). UenoHBanchereauJVinuesaCGPathophysiology of T follicular helper cells in humans and miceNat Immunol2015161421521:CAS:528:DC%2BC2MXpvFSisQ%3D%3D10.1038/ni.3054255944654459756 LundgrenASafety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I studyVaccine201432707770841:CAS:528:DC%2BC2cXhvVOkt77L10.1016/j.vaccine.2014.10.06925444830 LundgrenAKaimJJertbornMParallel analysis of mucosally derived B- and T-cell responses to an oral typhoid vaccine using simplified methodsVaccine200927452945361:CAS:528:DC%2BD1MXotFCrt7Y%3D10.1016/j.vaccine.2009.05.00519446596 PilkintonMAGreater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversionVaccine2017353293361:CAS:528:DC%2BC28XhvF2mtbvM10.1016/j.vaccine.2016.11.05927919633 ShamsuzzamanSRobust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic responsesVaccine200927138613921:CAS:528:DC%2BD1MXhvF2it7c%3D10.1016/j.vaccine.2008.12.04119146897 SchmittNBentebibelSEUenoHPhenotype and functions of memory Tfh cells in human bloodTrends Immunol2014354364421:CAS:528:DC%2BC2cXhtFSls7rI10.1016/j.it.2014.06.002249989034152409 MoritaRHuman blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretionImmunity2011341081211:CAS:528:DC%2BC3MXht1Wlu78%3D10.1016/j.immuni.2010.12.012212156583046815 AbudulaiLNProduction of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infectionPLoS One201712e017664110.1371/journal.pone.0176641284639775413043 SuhWKLife of T follicular helper cellsMol Cells2015381952011:CAS:528:DC%2BC2MXks1ektLg%3D10.14348/molcells.2015.233125537859 HolmgrenJDevelopment and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvantVaccine201331245724641:CAS:528:DC%2BC3sXls1SjtLk%3D10.1016/j.vaccine.2013.03.02723541621 KreherCRDittrichMTGuerkovRBoehmBOTary-LehmannMCD4+ and CD8+ cells in cryopreserved human PBMC maintain full functionality in cytokine ELISPOT assaysJ Immunol Methods200327879931:CAS:528:DC%2BD3sXmvVOhsbk%3D10.1016/S0022-1759(03)00226-612957398 BentebibelSEICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccinationSci Rep201662016NatSR...626494B1:CAS:528:DC%2BC28XptVSmtr0%3D10.1038/srep26494272311244882544 HeitAVaccination establishes clonal relatives of germinal center T cells in the blood of humansJ Exp Med2017214213921521:CAS:528:DC%2BC2sXhsFKlsb%2FL10.1084/jem.20161794286378845502430 TangyeSGAdvances in IL-21 biology - enhancing our understandi A Lundgren (20740_CR25) 2013; 31 C Havenar-Daughton (20740_CR39) 2016; 197 LN Abudulai (20740_CR30) 2017; 12 CR Kreher (20740_CR50) 2003; 278 L Sjokvist Ottsjo (20740_CR49) 2013; 81 MA Pilkinton (20740_CR33) 2017; 35 A Lundgren (20740_CR16) 2014; 32 S Alam (20740_CR36) 2014; 88 N Romberg (20740_CR45) 2013; 131 H Ueno (20740_CR7) 2015; 16 N Lycke (20740_CR2) 2012; 12 N Obeng-Adjei (20740_CR42) 2015; 13 AU Rasheed (20740_CR6) 2006; 36 S Leach (20740_CR27) 2013; 31 CM Paulos (20740_CR9) 2010; 2 SG Tangye (20740_CR11) 2015; 34 CG Vinuesa (20740_CR5) 2016; 34 P Bergqvist (20740_CR37) 2013; 6 R Morita (20740_CR12) 2011; 34 J Holmgren (20740_CR18) 2013; 31 J Holmgren (20740_CR51) 2017; 35 S Leach (20740_CR47) 2012; 7 G Saletti (20740_CR24) 2013; 8 M Quiding-Jarbrink (20740_CR19) 1997; 99 A Lundgren (20740_CR28) 2009; 27 20740_CR1 WK Suh (20740_CR4) 2015; 38 J He (20740_CR13) 2013; 39 K Matsui (20740_CR29) 2015; 10 A Heit (20740_CR34) 2017; 214 F Farooq (20740_CR41) 2016; 6 BT Schultz (20740_CR40) 2016; 44 M Larena (20740_CR48) 2015; 194 CS Ma (20740_CR32) 2015; 136 N Lycke (20740_CR46) 2010; 3 M Quiding (20740_CR23) 1991; 88 C Wang (20740_CR8) 2011; 12 S Shamsuzzaman (20740_CR22) 2009; 27 20740_CR26 A Kantele (20740_CR20) 1997; 158 A Lundgren (20740_CR17) 2016; 34 R Cubas (20740_CR43) 2015; 195 N Schmitt (20740_CR10) 2014; 35 SG Tangye (20740_CR3) 2013; 13 SE Bentebibel (20740_CR15) 2016; 6 PT Sage (20740_CR38) 2014; 124 P Brandtzaeg (20740_CR35) 2010; 39 EB Norton (20740_CR52) 2011; 18 C Ahren (20740_CR21) 1998; 66 SE Bentebibel (20740_CR14) 2013; 5 M Locci (20740_CR31) 2013; 39 DT Avery (20740_CR44) 2010; 207 |
| References_xml | – reference: BentebibelSEICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccinationSci Rep201662016NatSR...626494B1:CAS:528:DC%2BC28XptVSmtr0%3D10.1038/srep26494272311244882544 – reference: BergqvistPRe-utilization of germinal centers in multiple Peyer’s patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responsesMucosal Immunol201361221351:CAS:528:DC%2BC38XhtVSgtLvI10.1038/mi.2012.5622785230 – reference: LundgrenAClinical trial to evaluate safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli prototype vaccine containing CFA/I overexpressing bacteria and recombinantly produced LTB/CTB hybrid proteinVaccine201331116311701:CAS:528:DC%2BC3sXovFWhsg%3D%3D10.1016/j.vaccine.2012.12.06323306362 – reference: FarooqFCirculating follicular T helper cells and cytokine profile in humans following vaccination with the rVSV-ZEBOV Ebola vaccineSci Rep201662016NatSR...627944F1:CAS:528:DC%2BC28XhtVKit77O10.1038/srep27944273236854914957 – reference: AveryDTB cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humansJ Exp Med20102071551711:CAS:528:DC%2BC3cXht1ekt78%3D10.1084/jem.20091706200482852812540 – reference: UenoHBanchereauJVinuesaCGPathophysiology of T follicular helper cells in humans and miceNat Immunol2015161421521:CAS:528:DC%2BC2MXpvFSisQ%3D%3D10.1038/ni.3054255944654459756 – reference: LundgrenAKaimJJertbornMParallel analysis of mucosally derived B- and T-cell responses to an oral typhoid vaccine using simplified methodsVaccine200927452945361:CAS:528:DC%2BD1MXotFCrt7Y%3D10.1016/j.vaccine.2009.05.00519446596 – reference: RombergNGain-of-function STAT1 mutations are associated with PD-L1 overexpression and a defect in B-cell survivalJ Allergy Clin Immunol2013131169116931:CAS:528:DC%2BC3sXisVGmtbY%3D10.1016/j.jaci.2013.01.004234030483672340 – reference: MaCSMonogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficienciesJ Allergy Clin Immunol20151369931006 e10011:CAS:528:DC%2BC2MXhtFehtb3J10.1016/j.jaci.2015.05.036261625725042203 – reference: BentebibelSEInduction of ICOS+ CXCR3+ CXCR5+ TH cells correlates with antibody responses to influenza vaccinationSci Transl Med20135176ra13210.1126/scitranslmed.3005191 – reference: VinuesaCGLintermanMAYuDMacLennanICFollicular Helper T CellsAnnu Rev Immunol2016343353681:CAS:528:DC%2BC28XivFKlsrw%3D10.1146/annurev-immunol-041015-05560526907215 – reference: Havenar-DaughtonCCytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker TechniqueJ Immunol201619799410021:CAS:528:DC%2BC28XhtFOktLvE10.4049/jimmunol.1600320273355024955744 – reference: LarenaMHolmgrenJLebensMTerrinoniMLundgrenACholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signalingJ Immunol2015194382938391:CAS:528:DC%2BC2MXlvVejur4%3D10.4049/jimmunol.140163325786687 – reference: SalettiGCuburuNYangJSDeyACzerkinskyCEnzyme-linked immunospot assays for direct ex vivo measurement of vaccine-induced human humoral immune responses in bloodNat Protoc201381073108710.1038/nprot.2013.05823660756 – reference: AhrenCJertbornMSvennerholmAMIntestinal immune responses to an inactivated oral enterotoxigenic Escherichia coli vaccine and associated immunoglobulin A responses in bloodInfect Immun199866331133161:CAS:528:DyaK1cXktFCjsrY%3D9632600108347 – reference: KreherCRDittrichMTGuerkovRBoehmBOTary-LehmannMCD4+ and CD8+ cells in cryopreserved human PBMC maintain full functionality in cytokine ELISPOT assaysJ Immunol Methods200327879931:CAS:528:DC%2BD3sXmvVOhsbk%3D10.1016/S0022-1759(03)00226-612957398 – reference: LyckeNRecent progress in mucosal vaccine development: potential and limitationsNature Reviews Immunology2012125926051:CAS:528:DC%2BC38XhtV2itbjM10.1038/nri325122828912 – reference: NortonEBLawsonLBFreytagLCClementsJDCharacterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvantClin Vaccine Immunol2011185465511:CAS:528:DC%2BC3MXkvVaisbo%3D10.1128/CVI.00538-10212889943122563 – reference: LeachSClementsJDKaimJLundgrenAThe adjuvant double mutant Escherichia coli heat labile toxin enhances IL-17A production in human T cells specific for bacterial vaccine antigensPLoS One20127e517182012PLoSO...751718L1:CAS:528:DC%2BC3sXlsVCktA%3D%3D10.1371/journal.pone.0051718232847533527457 – reference: HolmgrenJCorrelates of protection for enteric vaccinesVaccine201735335533631:CAS:528:DC%2BC2sXnvFCqtLY%3D10.1016/j.vaccine.2017.05.00528504192 – reference: Quiding-JarbrinkMDifferential expression of tissue-specific adhesion molecules on human circulating antibody-forming cells after systemic, enteric, and nasal immunizations. A molecular basis for the compartmentalization of effector B cell responsesJ Clin Invest199799128112861:CAS:528:DyaK2sXhvFyhsLo%3D10.1172/JCI1192869077537507943 – reference: PaulosCMThe inducible costimulator (ICOS) is critical for the development of human T(H)17 cellsSci Transl Med2010255ra7810.1126/scitranslmed.300044820980695 – reference: Sjokvist OttsjoLFlachCFClementsJHolmgrenJRaghavanSA double mutant heat-labile toxin from Escherichia coli, LT(R192G/L211A), is an effective mucosal adjuvant for vaccination against Helicobacter pylori infectionInfect Immun2013811532154010.1128/IAI.01407-12234393053647992 – reference: KanteleAHoming potentials of circulating lymphocytes in humans depend on the site of activation: oral, but not parenteral, typhoid vaccination induces circulating antibody-secreting cells that all bear homing receptors directing them to the gutJ Immunol19971585745791:CAS:528:DyaK2sXmtFequg%3D%3D8992970 – reference: ShamsuzzamanSRobust gut associated vaccine-specific antibody-secreting cell responses are detected at the mucosal surface of Bangladeshi subjects after immunization with an oral killed bivalent V. cholerae O1/O139 whole cell cholera vaccine: comparison with other mucosal and systemic responsesVaccine200927138613921:CAS:528:DC%2BD1MXhvF2it7c%3D10.1016/j.vaccine.2008.12.04119146897 – reference: LocciMHuman circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responsesImmunity2013397587691:CAS:528:DC%2BC3sXhsVertbjL10.1016/j.immuni.2013.08.031240353653996844 – reference: BrandtzaegPFunction of mucosa-associated lymphoid tissue in antibody formationImmunol Invest2010393033551:CAS:528:DC%2BC3cXlslegtbk%3D10.3109/0882013100368036920450282 – reference: SagePTAlvarezDGodecJvon AndrianUHSharpeAHCirculating T follicular regulatory and helper cells have memory-like propertiesJ Clin Invest20141245191520410.1172/JCI76861253474694348955 – reference: Obeng-AdjeiNCirculating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in ChildrenCell Rep2015134254391:CAS:528:DC%2BC2MXhs1SqsLrN10.1016/j.celrep.2015.09.004264408974607674 – reference: TangyeSGMaCSBrinkRDeenickEKThe good, the bad and the ugly - TFH cells in human health and diseaseNat Rev Immunol2013134124261:CAS:528:DC%2BC3sXnslansL0%3D10.1038/nri344723681096 – reference: TangyeSGAdvances in IL-21 biology - enhancing our understanding of human diseaseCurr Opin Immunol2015341071151:CAS:528:DC%2BC2MXktFemu7o%3D10.1016/j.coi.2015.02.01025801685 – reference: Carpenter, C. M. et al. Comparison of the antibody in lymphocyte supernatant (ALS) and ELISPOT assays for detection of mucosal immune responses to antigens of enterotoxigenic Escherichia coli in challenged and vaccinated volunteers. Vaccine24, 3709–3718, https://doi.org/10.1016/j.vaccine.2005.07.022 (2006). – reference: HeJCirculating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposureImmunity2013397707811:CAS:528:DC%2BC3sXhs1eqtLjJ10.1016/j.immuni.2013.09.00724138884 – reference: HeitAVaccination establishes clonal relatives of germinal center T cells in the blood of humansJ Exp Med2017214213921521:CAS:528:DC%2BC2sXhsFKlsb%2FL10.1084/jem.20161794286378845502430 – reference: QuidingMIntestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-gamma production and evokes local immunological memoryJ Clin Invest1991881431481:CAS:528:DyaK3MXltFags7w%3D10.1172/JCI1152701905327296014 – reference: LyckeNBemarkMMucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxinsMucosal Immunol201035565661:CAS:528:DC%2BC3cXhtlSgsL%2FL10.1038/mi.2010.5420844480 – reference: LeachSLundgrenASvennerholmAMDifferent kinetics of circulating antibody-secreting cell responses after primary and booster oral immunizations: a tool for assessing immunological memoryVaccine201331303530381:CAS:528:DC%2BC3sXosVOntbk%3D10.1016/j.vaccine.2013.04.06623664997 – reference: CubasRReversible Reprogramming of Circulating Memory T Follicular Helper Cell Function during Chronic HIV InfectionJ Immunol2015195562556361:CAS:528:DC%2BC2MXhvFGnt73N10.4049/jimmunol.1501524265466094670798 – reference: SchmittNBentebibelSEUenoHPhenotype and functions of memory Tfh cells in human bloodTrends Immunol2014354364421:CAS:528:DC%2BC2cXhtFSls7rI10.1016/j.it.2014.06.002249989034152409 – reference: SchultzBTCirculating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper FunctionsImmunity2016441671781:CAS:528:DC%2BC28XmvVaqsA%3D%3D10.1016/j.immuni.2015.12.01126795249 – reference: WangCHillsamerPKimCHPhenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsetsBMC Immunol201112531:CAS:528:DC%2BC3MXhtlGqsLjJ10.1186/1471-2172-12-53219141883184275 – reference: MoritaRHuman blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretionImmunity2011341081211:CAS:528:DC%2BC3MXht1Wlu78%3D10.1016/j.immuni.2010.12.012212156583046815 – reference: AlamSKnowldenZASangsterMYSantAJCD4 T cell help is limiting and selective during the primary B cell response to influenza virus infectionJ Virol20148831432410.1128/JVI.02077-13241553793911719 – reference: HolmgrenJDevelopment and preclinical evaluation of safety and immunogenicity of an oral ETEC vaccine containing inactivated E. coli bacteria overexpressing colonization factors CFA/I, CS3, CS5 and CS6 combined with a hybrid LT/CT B subunit antigen, administered alone and together with dmLT adjuvantVaccine201331245724641:CAS:528:DC%2BC3sXls1SjtLk%3D10.1016/j.vaccine.2013.03.02723541621 – reference: AbudulaiLNProduction of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS+ circulating memory T follicular-helper cells which is impaired by HIV infectionPLoS One201712e017664110.1371/journal.pone.0176641284639775413043 – reference: LundgrenAJertbornMSvennerholmAMInduction of long term mucosal immunological memory in humans by an oral inactivated multivalent enterotoxigenic Escherichia coli vaccineVaccine201634313231401:CAS:528:DC%2BC28XnsVWntrg%3D10.1016/j.vaccine.2016.04.05527133878 – reference: PilkintonMAGreater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversionVaccine2017353293361:CAS:528:DC%2BC28XhvF2mtbvM10.1016/j.vaccine.2016.11.05927919633 – reference: RasheedAURahnHPSallustoFLippMMullerGFollicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expressionEur J Immunol200636189219031:CAS:528:DC%2BD28XnslOms74%3D10.1002/eji.20063613616791882 – reference: Czerkinsky, C. & Holmgren, J. Vaccines against enteric infections for the developing world. Philos Trans R Soc Lond B Biol Sci370, https://doi.org/10.1098/rstb.2015.0142 (2015). – reference: MatsuiKCirculating CXCR5(+)CD4(+) T Follicular-Like Helper Cell and Memory B Cell Responses to Human Papillomavirus VaccinesPLoS One201510e013719510.1371/journal.pone.0137195263330704557948 – reference: SuhWKLife of T follicular helper cellsMol Cells2015381952011:CAS:528:DC%2BC2MXks1ektLg%3D10.14348/molcells.2015.233125537859 – reference: LundgrenASafety and immunogenicity of an improved oral inactivated multivalent enterotoxigenic Escherichia coli (ETEC) vaccine administered alone and together with dmLT adjuvant in a double-blind, randomized, placebo-controlled Phase I studyVaccine201432707770841:CAS:528:DC%2BC2cXhvVOkt77L10.1016/j.vaccine.2014.10.06925444830 – volume: 88 start-page: 143 year: 1991 ident: 20740_CR23 publication-title: J Clin Invest doi: 10.1172/JCI115270 – volume: 13 start-page: 412 year: 2013 ident: 20740_CR3 publication-title: Nat Rev Immunol doi: 10.1038/nri3447 – volume: 36 start-page: 1892 year: 2006 ident: 20740_CR6 publication-title: Eur J Immunol doi: 10.1002/eji.200636136 – volume: 6 year: 2016 ident: 20740_CR41 publication-title: Sci Rep doi: 10.1038/srep27944 – volume: 124 start-page: 5191 year: 2014 ident: 20740_CR38 publication-title: J Clin Invest doi: 10.1172/JCI76861 – volume: 66 start-page: 3311 year: 1998 ident: 20740_CR21 publication-title: Infect Immun doi: 10.1128/IAI.66.7.3311-3316.1998 – volume: 35 start-page: 329 year: 2017 ident: 20740_CR33 publication-title: Vaccine doi: 10.1016/j.vaccine.2016.11.059 – ident: 20740_CR26 doi: 10.1016/j.vaccine.2005.07.022 – volume: 195 start-page: 5625 year: 2015 ident: 20740_CR43 publication-title: J Immunol doi: 10.4049/jimmunol.1501524 – volume: 39 start-page: 770 year: 2013 ident: 20740_CR13 publication-title: Immunity doi: 10.1016/j.immuni.2013.09.007 – volume: 12 start-page: e0176641 year: 2017 ident: 20740_CR30 publication-title: PLoS One doi: 10.1371/journal.pone.0176641 – volume: 34 start-page: 108 year: 2011 ident: 20740_CR12 publication-title: Immunity doi: 10.1016/j.immuni.2010.12.012 – volume: 99 start-page: 1281 year: 1997 ident: 20740_CR19 publication-title: J Clin Invest doi: 10.1172/JCI119286 – volume: 39 start-page: 303 year: 2010 ident: 20740_CR35 publication-title: Immunol Invest doi: 10.3109/08820131003680369 – volume: 197 start-page: 994 year: 2016 ident: 20740_CR39 publication-title: J Immunol doi: 10.4049/jimmunol.1600320 – volume: 27 start-page: 1386 year: 2009 ident: 20740_CR22 publication-title: Vaccine doi: 10.1016/j.vaccine.2008.12.041 – volume: 278 start-page: 79 year: 2003 ident: 20740_CR50 publication-title: J Immunol Methods doi: 10.1016/S0022-1759(03)00226-6 – volume: 12 start-page: 53 year: 2011 ident: 20740_CR8 publication-title: BMC Immunol doi: 10.1186/1471-2172-12-53 – volume: 2 start-page: 55ra78 year: 2010 ident: 20740_CR9 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3000448 – volume: 39 start-page: 758 year: 2013 ident: 20740_CR31 publication-title: Immunity doi: 10.1016/j.immuni.2013.08.031 – volume: 81 start-page: 1532 year: 2013 ident: 20740_CR49 publication-title: Infect Immun doi: 10.1128/IAI.01407-12 – volume: 10 start-page: e0137195 year: 2015 ident: 20740_CR29 publication-title: PLoS One doi: 10.1371/journal.pone.0137195 – volume: 5 start-page: 176ra132 year: 2013 ident: 20740_CR14 publication-title: Sci Transl Med doi: 10.1126/scitranslmed.3005191 – volume: 31 start-page: 2457 year: 2013 ident: 20740_CR18 publication-title: Vaccine doi: 10.1016/j.vaccine.2013.03.027 – ident: 20740_CR1 doi: 10.1098/rstb.2015.0142 – volume: 44 start-page: 167 year: 2016 ident: 20740_CR40 publication-title: Immunity doi: 10.1016/j.immuni.2015.12.011 – volume: 3 start-page: 556 year: 2010 ident: 20740_CR46 publication-title: Mucosal Immunol doi: 10.1038/mi.2010.54 – volume: 31 start-page: 3035 year: 2013 ident: 20740_CR27 publication-title: Vaccine doi: 10.1016/j.vaccine.2013.04.066 – volume: 131 start-page: 1691 year: 2013 ident: 20740_CR45 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2013.01.004 – volume: 31 start-page: 1163 year: 2013 ident: 20740_CR25 publication-title: Vaccine doi: 10.1016/j.vaccine.2012.12.063 – volume: 8 start-page: 1073 year: 2013 ident: 20740_CR24 publication-title: Nat Protoc doi: 10.1038/nprot.2013.058 – volume: 7 start-page: e51718 year: 2012 ident: 20740_CR47 publication-title: PLoS One doi: 10.1371/journal.pone.0051718 – volume: 38 start-page: 195 year: 2015 ident: 20740_CR4 publication-title: Mol Cells doi: 10.14348/molcells.2015.2331 – volume: 6 year: 2016 ident: 20740_CR15 publication-title: Sci Rep doi: 10.1038/srep26494 – volume: 12 start-page: 592 year: 2012 ident: 20740_CR2 publication-title: Nature Reviews Immunology doi: 10.1038/nri3251 – volume: 32 start-page: 7077 year: 2014 ident: 20740_CR16 publication-title: Vaccine doi: 10.1016/j.vaccine.2014.10.069 – volume: 35 start-page: 436 year: 2014 ident: 20740_CR10 publication-title: Trends Immunol doi: 10.1016/j.it.2014.06.002 – volume: 34 start-page: 3132 year: 2016 ident: 20740_CR17 publication-title: Vaccine doi: 10.1016/j.vaccine.2016.04.055 – volume: 158 start-page: 574 year: 1997 ident: 20740_CR20 publication-title: J Immunol doi: 10.4049/jimmunol.158.2.574 – volume: 34 start-page: 335 year: 2016 ident: 20740_CR5 publication-title: Annu Rev Immunol doi: 10.1146/annurev-immunol-041015-055605 – volume: 16 start-page: 142 year: 2015 ident: 20740_CR7 publication-title: Nat Immunol doi: 10.1038/ni.3054 – volume: 136 start-page: 993 year: 2015 ident: 20740_CR32 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2015.05.036 – volume: 214 start-page: 2139 year: 2017 ident: 20740_CR34 publication-title: J Exp Med doi: 10.1084/jem.20161794 – volume: 13 start-page: 425 year: 2015 ident: 20740_CR42 publication-title: Cell Rep doi: 10.1016/j.celrep.2015.09.004 – volume: 18 start-page: 546 year: 2011 ident: 20740_CR52 publication-title: Clin Vaccine Immunol doi: 10.1128/CVI.00538-10 – volume: 35 start-page: 3355 year: 2017 ident: 20740_CR51 publication-title: Vaccine doi: 10.1016/j.vaccine.2017.05.005 – volume: 194 start-page: 3829 year: 2015 ident: 20740_CR48 publication-title: J Immunol doi: 10.4049/jimmunol.1401633 – volume: 207 start-page: 155 year: 2010 ident: 20740_CR44 publication-title: J Exp Med doi: 10.1084/jem.20091706 – volume: 6 start-page: 122 year: 2013 ident: 20740_CR37 publication-title: Mucosal Immunol doi: 10.1038/mi.2012.56 – volume: 34 start-page: 107 year: 2015 ident: 20740_CR11 publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2015.02.010 – volume: 88 start-page: 314 year: 2014 ident: 20740_CR36 publication-title: J Virol doi: 10.1128/JVI.02077-13 – volume: 27 start-page: 4529 year: 2009 ident: 20740_CR28 publication-title: Vaccine doi: 10.1016/j.vaccine.2009.05.005 |
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| Title | Activated T follicular helper-like cells are released into blood after oral vaccination and correlate with vaccine specific mucosal B-cell memory |
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