Progesterone Receptors: A Key for Neuroprotection in Experimental Stroke

• Published in: Endocrinology (Philadelphia) Vol. 153; no. 8; pp. 3747 - 3757
• Main Authors: Liu, Ailing, Margaill, Isabelle, Zhang, Shaodong, Labombarda, Florencia, Coqueran, Bérard, Delespierre, Brigitte, Liere, Philippe, Marchand-Leroux, Catherine, O'Malley, Bert W, Lydon, John P, De Nicola, Alejandro F, Sitruk-Ware, Regine, Mattern, Claudia, Plotkine, Michel, Schumacher, Michael, Guennoun, Rachida
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Endocrine Society 01.08.2012
• Subjects: Animals; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Fundamental and applied biological sciences. Psychology; Male; Medical sciences; Mice; Mice, Knockout; Neuroendocrinology; Neurology; Norprogesterones - pharmacology; Norprogesterones - therapeutic use; Pregnanolone - pharmacology; Pregnanolone - therapeutic use; Progesterone - pharmacology; Progesterone - therapeutic use; Receptors, Progesterone - metabolism; Signal Transduction - drug effects; Stroke - drug therapy; Stroke - metabolism; Stroke - prevention & control; Vascular diseases and vascular malformations of the nervous system; Vertebrates: endocrinology; Vascular disease; Neuroprotection; Nervous system diseases; Stroke; Central nervous system disease; Cardiovascular disease; Progesterone receptor; Cerebrovascular disease; Cerebral disorder

Progesterone receptors (PR) are expressed throughout the brain. However, their functional significance remains understudied. Here we report a novel role of PR as crucial mediators of neuroprotection using a model of transient middle cerebral artery occlusion and PR knockout mice. Six hours after isc...