SimplySmart_v1, a new tool for the analysis of DNA damage optimized in primary neuronal cultures

• Published in: BMC bioinformatics Vol. 25; no. 1; pp. 318 - 18
• Main Authors: Koirala, Sushma, Sharma, Harman, Chew, Yee Lian, Konopka, Anna
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.10.2024; BioMed Central; BMC
• Subjects: Amyotrophic lateral sclerosis; Analysis; Animals; Bioinformatics; Carbon dioxide; Cell cycle; Cells, Cultured; Cloning; Comparative analysis; Computational biology; Damage detection; Dementia; Deoxyribonucleic acid; DNA; DNA Breaks, Double-Stranded; DNA Damage; DNA damage foci; DNA damage in neurons; Etoposide; Methods; Mice; Neurodegeneration; Neuronal culture; Neurons; Neurons - cytology; Neurons - metabolism; Open source software; Pathophysiology; Physiological aspects; Physiology; Python application; RNA-binding protein; Software; Source programs; Australia; Python application; Neuronal culture; DNA damage foci; Neurodegeneration; Analysis; DNA damage in neurons

The increased interest in research on DNA damage in neurodegeneration has created a need for the development of tools dedicated to the analysis of DNA damage in neurons. Double-stranded breaks (DSBs) are among the most detrimental types of DNA damage and have become a subject of intensive research....