Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1

• Published in: Cell communication and signaling Vol. 23; no. 1; pp. 62 - 15
• Main Authors: Li, Guanjun, Huang, Ling, Gu, Di, Wang, Peili, Yi, Letai, Kuang, Wenhua, Zhang, Ying, Zhang, Junzhe, Liu, Dandan, Shi, Qiaoli, Tang, Huan, Sun, Jichao, Zeng, Guohua, Peng, Xin, Wang, Jigang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.02.2025; BioMed Central; BMC
• Subjects: Acids; Aconitate decarboxylase; Activity-based chemical proteomic; Analysis; Animals; Caffeic acid; Caffeic Acids - pharmacology; Caffeic Acids - therapeutic use; Carboxy-Lyases - metabolism; Care and treatment; Cell activation; Cell Line; Chromatography; Coffee; Complications and side effects; Convulsions & seizures; Cytokines; Diagnosis; Enzymatic activity; Epilepsy; Experiments; Fluorescent antibody technique; Heat transfer; Immunofluorescence; Inflammation; Kindling; Laboratory animals; Lipopolysaccharides; Male; Medical research; Mice; Molecular modelling; Natural products and herbs; Network pharmacology; Neurological diseases; Neurological disorders; NF-κB protein; Nitric oxide; Pentylenetetrazole; Phytomedicine; Polyphenols; Proteins; Proteomics; Proteomics - methods; Seizures; Seizures (Medicine); Seizures - chemically induced; Seizures - drug therapy; Seizures - metabolism; United States; Activity-based chemical proteomic; Natural products and herbs; Network pharmacology; Phytomedicine

Epilepsy is a neurological disorder characterized by recurrent seizures, tightly associated with neuroinflammation. Activation of inflammatory cells and molecules in damaged nervous tissues plays a pivotal role in epilepsy. Caffeic acid, one of the most abundant polyphenols in coffee, has shown pote...