Determinants of Bone Material Strength and Cortical Porosity in Patients with Type 2 Diabetes Mellitus

• Published in: The journal of clinical endocrinology and metabolism Vol. 105; no. 10; pp. e3718 - e3729
• Main Authors: Samakkarnthai, Parinya, Sfeir, Jad G, Atkinson, Elizabeth J, Achenbach, Sara J, Wennberg, Paul W, Dyck, Peter J, Tweed, Amanda J, Volkman, Tammie L, Amin, Shreyasee, Farr, Joshua N, Vella, Adrian, Drake, Matthew T, Khosla, Sundeep
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.10.2020
• Subjects: Advanced glycation end products; Advanced glycosylation end products; Age; Aged; Ankle; Ankle Brachial Index; Blood flow; Body mass index; Bone Density - physiology; Bones; Complications and side effects; Computed tomography; Cortical bone; Cross-Sectional Studies; Density; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Angiopathies - diagnosis; Diabetic Angiopathies - epidemiology; Diabetic Angiopathies - physiopathology; Diabetic neuropathy; Female; Fractures; Glycation End Products, Advanced - analysis; Glycation End Products, Advanced - metabolism; Glycosylation; Health aspects; Humans; Male; Microvasculature; Middle Aged; Online Only; Osteoporosis; Osteoporotic Fractures - epidemiology; Osteoporotic Fractures - physiopathology; Oxygen tension; Porosity; Radius; Radius - diagnostic imaging; Radius - physiopathology; Retinopathy; Risk Factors; Skin - chemistry; Skin - metabolism; Tibia; Tibia - diagnostic imaging; Tibia - physiopathology; Tomography, X-Ray Computed; Type 2 diabetes; Vascular diseases; United States; bone; AGEs; vascular disease; osteoporosis; diabetes

Abstract Context Reduced bone material strength index (BMSi) and increased cortical porosity (CtPo) have emerged as potentially contributing to fracture risk in type 2 diabetes mellitus (T2DM) patients. Objective To determine whether BMSi or CtPo are related to other diabetic complications. Design C...