An alternative pluripotent state confers interspecies chimaeric competency

• Published in: Nature (London) Vol. 521; no. 7552; pp. 316 - 321
• Main Authors: Wu, Jun, Okamura, Daiji, Li, Mo, Suzuki, Keiichiro, Luo, Chongyuan, Ma, Li, He, Yupeng, Li, Zhongwei, Benner, Chris, Tamura, Isao, Krause, Marie N., Nery, Joseph R., Du, Tingting, Zhang, Zhuzhu, Hishida, Tomoaki, Takahashi, Yuta, Aizawa, Emi, Kim, Na Young, Lajara, Jeronimo, Guillen, Pedro, Campistol, Josep M., Esteban, Concepcion Rodriguez, Ross, Pablo J., Saghatelian, Alan, Ren, Bing, Ecker, Joseph R., Belmonte, Juan Carlos Izpisua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.05.2015; Nature Publishing Group
• Subjects: 631/532/2064/2158; Animals; Cell Culture Techniques - methods; Cell Line; Chimera; Cloning; Embryonic growth stage; Embryonic Stem Cells - cytology; Embryos; Epigenetics; Female; Gene expression; Germ Layers - cytology; Humanities and Social Sciences; Humans; Induced Pluripotent Stem Cells - cytology; Male; Metabolism; Mice; Morphology; multidisciplinary; Pan troglodytes; Pluripotent Stem Cells - cytology; Pluripotent Stem Cells - metabolism; Regenerative Medicine; Science; Species Specificity; Stem cells

Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a...