An alternative pluripotent state confers interspecies chimaeric competency

Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a...

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Published inNature (London) Vol. 521; no. 7552; pp. 316 - 321
Main Authors Wu, Jun, Okamura, Daiji, Li, Mo, Suzuki, Keiichiro, Luo, Chongyuan, Ma, Li, He, Yupeng, Li, Zhongwei, Benner, Chris, Tamura, Isao, Krause, Marie N., Nery, Joseph R., Du, Tingting, Zhang, Zhuzhu, Hishida, Tomoaki, Takahashi, Yuta, Aizawa, Emi, Kim, Na Young, Lajara, Jeronimo, Guillen, Pedro, Campistol, Josep M., Esteban, Concepcion Rodriguez, Ross, Pablo J., Saghatelian, Alan, Ren, Bing, Ecker, Joseph R., Belmonte, Juan Carlos Izpisua
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 21.05.2015
Nature Publishing Group
Subjects
631/532/2064/2158
Animals
Cell Culture Techniques - methods
Cell Line
Chimera
Cloning
Embryonic growth stage
Embryonic Stem Cells - cytology
Embryos
Epigenetics
Female
Gene expression
Germ Layers - cytology
Humanities and Social Sciences
Humans
Induced Pluripotent Stem Cells - cytology
Male
Metabolism
Mice
Morphology
multidisciplinary
Pan troglodytes
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Regenerative Medicine
Science
Species Specificity
Stem cells
Online AccessGet full text

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Abstract Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution. A previously unknown type of stem cell that can engraft in specific regions of the mouse epiblast is described; these region-selective pluripotent stem cells display notable intra- and inter-specific chimaera competency and will help to further our understanding of mammalian development. An alternative stem cell state Embryonic stem cells and epiblast stem cells represent two commonly accepted pluripotent states, derived from distinct time points during mouse embryogenesis. By modulating signalling components in the culture medium used for derivation of pluripotent stem cells from mouse epiblasts, Izpisua Belmonte and colleagues have identified an additional stem cell state with characteristics distinct from these two classes. These cells can engraft in specific regions of the mouse epiblast and are thus named region-selective pluripotent stem cells (rsPSCs). Cells with similar properties were also obtained from cultures of mouse and primate pluripotent stem cell lines. The study of rsPSCs will allow further understanding of mammalian development.
AbstractList Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum oforganismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution.
Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution. A previously unknown type of stem cell that can engraft in specific regions of the mouse epiblast is described; these region-selective pluripotent stem cells display notable intra- and inter-specific chimaera competency and will help to further our understanding of mammalian development. An alternative stem cell state Embryonic stem cells and epiblast stem cells represent two commonly accepted pluripotent states, derived from distinct time points during mouse embryogenesis. By modulating signalling components in the culture medium used for derivation of pluripotent stem cells from mouse epiblasts, Izpisua Belmonte and colleagues have identified an additional stem cell state with characteristics distinct from these two classes. These cells can engraft in specific regions of the mouse epiblast and are thus named region-selective pluripotent stem cells (rsPSCs). Cells with similar properties were also obtained from cultures of mouse and primate pluripotent stem cell lines. The study of rsPSCs will allow further understanding of mammalian development.
Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution.
Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution.Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture parameters, a stem-cell type with unique spatial characteristics and distinct molecular and functional features, designated as region-selective pluripotent stem cells (rsPSCs), can be efficiently obtained from mouse embryos and primate pluripotent stem cells, including humans. The ease of culturing and editing the genome of human rsPSCs offers advantages for regenerative medicine applications. The unique ability of human rsPSCs to generate post-implantation interspecies chimaeric embryos may facilitate our understanding of early human development and evolution.
Author Li, Zhongwei
Lajara, Jeronimo
Hishida, Tomoaki
Guillen, Pedro
Ross, Pablo J.
Wu, Jun
Kim, Na Young
Ma, Li
Belmonte, Juan Carlos Izpisua
He, Yupeng
Campistol, Josep M.
Li, Mo
Krause, Marie N.
Okamura, Daiji
Saghatelian, Alan
Ren, Bing
Nery, Joseph R.
Tamura, Isao
Du, Tingting
Ecker, Joseph R.
Suzuki, Keiichiro
Aizawa, Emi
Takahashi, Yuta
Benner, Chris
Zhang, Zhuzhu
Esteban, Concepcion Rodriguez
Luo, Chongyuan
AuthorAffiliation 10 University of California, Davis, Davis, California 95616, USA
4 The Salk Institute for Biological Studies, Integrated Genomics, La Jolla, California 92037, USA
8 Fundacion Pedro Guillen, Clínica Cemtro, Avenida Ventisquero de la Condesa, 42, 28035 Madrid, Spain
9 Hospital Clinic of Barcelona, Carrer Villarroel, 170, 08036 Barcelona, Spain
1 The Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, California 92037, USA
3 The Salk Institute for Biological Studies, Genomic Analysis Laboratory, La Jolla, California 92037, USA
6 Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8577, Japan
11 The Salk Institute for Biological Studies, Peptide Biology Laboratory, La Jolla, California 92037, USA
7 Grado en Medicina, Universidad Católica, San Antonio de Murcia, Campus de los Jerónimos, 135, Guadalupe 30107, Spain
5 Ludwig Institute for Cancer Research, University of California, San Diego School of Medicine, D
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– name: 2 Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
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– name: 11 The Salk Institute for Biological Studies, Peptide Biology Laboratory, La Jolla, California 92037, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/25945737$$D View this record in MEDLINE/PubMed
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These authors contributed equally to this work.
Present address: Department of Advanced Bioscience, Graduate School of Agriculture, Kinki University, 3327-204 Nakamachi, Nara 631-8505, Japan.
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Snippet Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at...
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SubjectTerms 631/532/2064/2158
Animals
Cell Culture Techniques - methods
Cell Line
Chimera
Cloning
Embryonic growth stage
Embryonic Stem Cells - cytology
Embryos
Epigenetics
Female
Gene expression
Germ Layers - cytology
Humanities and Social Sciences
Humans
Induced Pluripotent Stem Cells - cytology
Male
Metabolism
Mice
Morphology
multidisciplinary
Pan troglodytes
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Regenerative Medicine
Science
Species Specificity
Stem cells
Title An alternative pluripotent state confers interspecies chimaeric competency
URI https://link.springer.com/article/10.1038/nature14413
https://www.ncbi.nlm.nih.gov/pubmed/25945737
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https://pubmed.ncbi.nlm.nih.gov/PMC5278765
Volume 521
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