Nitric oxide production by Peromyscus yucatanicus (Rodentia) infected with Leishmania (Leishmania) mexicana

Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO) generally plays a crucial role in the containment and elimination of Leishmania. The aim of this study was to determine the amount of NO prod...

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Published inMemórias do Instituto Oswaldo Cruz Vol. 108; no. 2; pp. 172 - 177
Main Authors Loría-Cervera, Elsy Nalleli, Sosa-Bibiano, Erika Ivett, Villanueva-Lizama, Liliana Estefanía, Van Wynsberghe, Nicole Raymonde, Canto-Lara, Silvia Beatriz, Batún-Cutz, José Luis, Andrade-Narváez, Fernando José
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Instituto Oswaldo Cruz, Ministério da Saúde 01.04.2013
Fundação Oswaldo Cruz (FIOCRUZ)
Subjects
Animals
Cricetidae
Disease Models, Animal
Kinetoplastida
Leishmania (L.) mexicana
Leishmania mexicana
Leishmania mexicana - immunology
Leishmaniasis, Cutaneous - immunology
Macrophages, Peritoneal - immunology
Macrophages, Peritoneal - parasitology
nitric oxide
Nitric Oxide - biosynthesis
PARASITOLOGY
Peromyscus - metabolism
Peromyscus - parasitology
Peromyscus yucatanicus
Rodentia
TROPICAL MEDICINE
Trypanosomatidae
nitric oxide
Peromyscus yucatanicus
Leishmania (L.) mexicana
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Abstract Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO) generally plays a crucial role in the containment and elimination of Leishmania. The aim of this study was to determine the amount of NO produced by P. yucatanicus infected with L. (L.) mexicana. Subclinical and clinical infections were established in P. yucatanicus through inoculation with 1 x 10 2 and 2.5 x 10 6 promastigotes, respectively. Peritoneal macrophages were cultured alone or co-cultured with lymphocytes with or without soluble Leishmania antigen. The level of NO production was determined using the Griess reaction. The amount of NO produced was significantly higher (p ≤ 0.0001) in co-cultured macrophages and lymphocytes than in macrophages cultured alone. No differences in NO production were found between P. yucatanicus with subclinical L. (L.) mexicana infections and animals with clinical infections. These results support the hypothesis that the immunological mechanisms of NO production in P. yucatanicus are similar to those described in mouse models of leishmaniasis and, despite NO production, P. yucatanicus is unable to clear the parasite infection.
AbstractList Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO) generally plays a crucial role in the containment and elimination of Leishmania. The aim of this study was to determine the amount of NO produced by P. yucatanicus infected with L. (L.) mexicana. Subclinical and clinical infections were established in P. yucatanicus through inoculation with 1 x 10 super(2) and 2.5 x 10 super(6) promastigotes, respectively. Peritoneal macrophages were cultured alone or co-cultured with lymphocytes with or without soluble Leishmania antigen. The level of NO production was determined using the Griess reaction. The amount of NO produced was significantly higher (p less than or equal to 0.0001) in co-cultured macrophages and lymphocytes than in macrophages cultured alone. No differences in NO production were found between P. yucatanicus with subclinical L. (L.) mexicana infections and animals with clinical infections. These results support the hypothesis that the immunological mechanisms of NO production in P. yucatanicus are similar to those described in mouse models of leishmaniasis and, despite NO production, P. yucatanicus is unable to clear the parasite infection.
Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO) generally plays a crucial role in the containment and elimination of Leishmania. The aim of this study was to determine the amount of NO produced by P. yucatanicus infected with L. (L.) mexicana. Subclinical and clinical infections were established in P. yucatanicus through inoculation with 1 x 10 2 and 2.5 x 10 6 promastigotes, respectively. Peritoneal macrophages were cultured alone or co-cultured with lymphocytes with or without soluble Leishmania antigen. The level of NO production was determined using the Griess reaction. The amount of NO produced was significantly higher (p ≤ 0.0001) in co-cultured macrophages and lymphocytes than in macrophages cultured alone. No differences in NO production were found between P. yucatanicus with subclinical L. (L.) mexicana infections and animals with clinical infections. These results support the hypothesis that the immunological mechanisms of NO production in P. yucatanicus are similar to those described in mouse models of leishmaniasis and, despite NO production, P. yucatanicus is unable to clear the parasite infection.
Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO) generally plays a crucial role in the containment and elimination of Leishmania. The aim of this study was to determine the amount of NO produced by P. yucatanicus infected with L. (L.) mexicana. Subclinical and clinical infections were established in P. yucatanicus through inoculation with 1 x 10 2 and 2.5 x 10 6 promastigotes, respectively. Peritoneal macrophages were cultured alone or co-cultured with lymphocytes with or without soluble Leishmania antigen. The level of NO production was determined using the Griess reaction. The amount of NO produced was significantly higher (p ≤ 0.0001) in co-cultured macrophages and lymphocytes than in macrophages cultured alone. No differences in NO production were found between P. yucatanicus with subclinical L. (L.) mexicana infections and animals with clinical infections. These results support the hypothesis that the immunological mechanisms of NO production in P. yucatanicus are similar to those described in mouse models of leishmaniasis and, despite NO production, P. yucatanicus is unable to clear the parasite infection.
Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO) generally plays a crucial role in the containment and elimination of Leishmania. The aim of this study was to determine the amount of NO produced by P. yucatanicus infected with L. (L.) mexicana. Subclinical and clinical infections were established in P. yucatanicus through inoculation with 1 x 102 and 2.5 x 106 promastigotes, respectively. Peritoneal macrophages were cultured alone or co-cultured with lymphocytes with or without soluble Leishmania antigen. The level of NO production was determined using the Griess reaction. The amount of NO produced was significantly higher (p ≤ 0.0001) in co-cultured macrophages and lymphocytes than in macrophages cultured alone. No differences in NO production were found between P. yucatanicus with subclinical L. (L.) mexicana infections and animals with clinical infections. These results support the hypothesis that the immunological mechanisms of NO production in P. yucatanicus are similar to those described in mouse models of leishmaniasis and, despite NO production, P. yucatanicus is unable to clear the parasite infection.
Author Loría-Cervera, Elsy Nalleli
Villanueva-Lizama, Liliana Estefanía
Van Wynsberghe, Nicole Raymonde
Canto-Lara, Silvia Beatriz
Batún-Cutz, José Luis
Sosa-Bibiano, Erika Ivett
Andrade-Narváez, Fernando José
AuthorAffiliation Universidad Autónoma de Yucatán
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  surname: Loría-Cervera
  fullname: Loría-Cervera, Elsy Nalleli
  email: nalleli.cervera@uady.mx
  organization: Laboratorio de Inmunología, Centro de Investigaciones Regionales Dr Hideyo Noguchi, Universidad Autónoma de Yucatán, Yucatán, México. nalleli.cervera@uady.mx
– sequence: 2
  givenname: Erika Ivett
  surname: Sosa-Bibiano
  fullname: Sosa-Bibiano, Erika Ivett
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  givenname: Liliana Estefanía
  surname: Villanueva-Lizama
  fullname: Villanueva-Lizama, Liliana Estefanía
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  surname: Van Wynsberghe
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  givenname: Fernando José
  surname: Andrade-Narváez
  fullname: Andrade-Narváez, Fernando José
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Issue 2
Keywords nitric oxide
Peromyscus yucatanicus
Leishmania (L.) mexicana
Language English
Portuguese
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    fullname: Seidelin, H
– year: 1996
  publication-title: Guide for the Care and Use of Laboratory Animals
SSID ssj0027364
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Snippet Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO)...
Peromyscus yucatanicus (Rodentia: Cricetidae) is a primary reservoir of Leishmania (Leishmania) mexicana (Kinetoplastida: Trypanosomatidae). Nitric oxide (NO)...
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StartPage 172
SubjectTerms Animals
Cricetidae
Disease Models, Animal
Kinetoplastida
Leishmania (L.) mexicana
Leishmania mexicana
Leishmania mexicana - immunology
Leishmaniasis, Cutaneous - immunology
Macrophages, Peritoneal - immunology
Macrophages, Peritoneal - parasitology
nitric oxide
Nitric Oxide - biosynthesis
PARASITOLOGY
Peromyscus - metabolism
Peromyscus - parasitology
Peromyscus yucatanicus
Rodentia
TROPICAL MEDICINE
Trypanosomatidae
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Title Nitric oxide production by Peromyscus yucatanicus (Rodentia) infected with Leishmania (Leishmania) mexicana
URI https://www.ncbi.nlm.nih.gov/pubmed/23579796
https://search.proquest.com/docview/1326728781
https://search.proquest.com/docview/1412519425
https://pubmed.ncbi.nlm.nih.gov/PMC3970676
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https://doaj.org/article/22565cad2f8f4678973c6d4060641761
Volume 108
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