Association of gut microbiota with the pathogenesis of SARS-CoV-2 Infection in people living with HIV

People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed the temporal changes in the gut microbiota composition of hospitali...

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Published inBMC microbiology Vol. 24; no. 1; p. 6
Main Authors Ishizaka, Aya, Koga, Michiko, Mizutani, Taketoshi, Yamayoshi, Seiya, Iwatsuki-Horimoto, Kiyoko, Adachi, Eisuke, Suzuki, Yutaka, Kawaoka, Yoshihiro, Yotsuyanagi, Hiroshi
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 03.01.2024
BioMed Central
BMC
Subjects
Age
Bacteria
Care and treatment
CD4 antigen
Colitis
Comparative analysis
Complications
Coronaviruses
COVID-19
COVID-19 - complications
Development and progression
Digestive system
Dysbacteriosis
Dysbiosis
Enteritis
Fatty acids
Gastrointestinal Microbiome
Gastrointestinal tract
Health aspects
Hepatitis A
HIV
HIV (Viruses)
HIV Infections - complications
HIV patients
Homeostasis
Hospitals
Human immunodeficiency virus
Humans
Immunology
Infections
Inflammation
Inflammatory bowel disease
Intestinal microflora
Intestine
Lymphocytes
Lymphocytes T
Medical research
Medicine, Experimental
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Opportunist infection
Pathogenesis
Patients
Physiological aspects
Post-acute COVID-19 syndrome
Respiratory diseases
RNA
RNA, Ribosomal, 16S - genetics
rRNA 16S
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
T cells
Viral diseases
Japan
COVID-19
Microbiota
SARS-CoV-2
HIV
Post-acute COVID-19 syndrome
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Abstract People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed the temporal changes in the gut microbiota composition of hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and their correlation with COVID-19 severity. The 16S rRNA analysis results using stool samples (along the timeline from disease onset) from 12 hospitalized PLWH-CoV, whose median CD4 + T cell count was 671 cells/µl, were compared to those of 19 healthy people and 25 PLWH. Bacterial diversity in PLWH-CoV is not significantly different from that of healthy people and SARS-CoV-2 non-infected PLWH, but a significant difference in the microbiota diversity was observed in the classification according to the disease severity. Immediately after the disease onset, remarkable changes were observed in the gut microbiota of PLWH-CoV, and the changing with a decrease in some short-chain fatty acid-producing bacteria and an increase in colitis-related pathobiont. In the second week after disease onset, relative amounts of specific bacteria distinguished between disease severity. One month after the disease onset, dysbiosis of the gut microbiota persisted, and the number of Enterobacteriaceae, mainly Escherichia-Shigella, which is potentially pathogenic, increased and were enriched in patients who developed post-acute sequelae of COVID-19 (PASC). The changes in the gut microbiota associated with SARS-CoV-2 infection observed in PLWH in this study indicated a persistent decrease in SCFA-producing bacteria and an intestinal environment with an increase in opportunistic pathogens associated with enteritis. This report demonstrates that the intestinal environment in PLWH tends to show delayed improvement even after COVID-19 recovery, and highlights the importance of the dysbiosis associated with SARS-CoV-2 infection as a potential factor in the COVID-19 severity and the PASC in PLWH.
AbstractList People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed the temporal changes in the gut microbiota composition of hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and their correlation with COVID-19 severity. The 16S rRNA analysis results using stool samples (along the timeline from disease onset) from 12 hospitalized PLWH-CoV, whose median CD4 + T cell count was 671 cells/[micro]l, were compared to those of 19 healthy people and 25 PLWH. Bacterial diversity in PLWH-CoV is not significantly different from that of healthy people and SARS-CoV-2 non-infected PLWH, but a significant difference in the microbiota diversity was observed in the classification according to the disease severity. Immediately after the disease onset, remarkable changes were observed in the gut microbiota of PLWH-CoV, and the changing with a decrease in some short-chain fatty acid-producing bacteria and an increase in colitis-related pathobiont. In the second week after disease onset, relative amounts of specific bacteria distinguished between disease severity. One month after the disease onset, dysbiosis of the gut microbiota persisted, and the number of Enterobacteriaceae, mainly Escherichia-Shigella, which is potentially pathogenic, increased and were enriched in patients who developed post-acute sequelae of COVID-19 (PASC). The changes in the gut microbiota associated with SARS-CoV-2 infection observed in PLWH in this study indicated a persistent decrease in SCFA-producing bacteria and an intestinal environment with an increase in opportunistic pathogens associated with enteritis. This report demonstrates that the intestinal environment in PLWH tends to show delayed improvement even after COVID-19 recovery, and highlights the importance of the dysbiosis associated with SARS-CoV-2 infection as a potential factor in the COVID-19 severity and the PASC in PLWH.
Abstract Background People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed the temporal changes in the gut microbiota composition of hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and their correlation with COVID-19 severity. Result The 16S rRNA analysis results using stool samples (along the timeline from disease onset) from 12 hospitalized PLWH-CoV, whose median CD4 + T cell count was 671 cells/µl, were compared to those of 19 healthy people and 25 PLWH. Bacterial diversity in PLWH-CoV is not significantly different from that of healthy people and SARS-CoV-2 non-infected PLWH, but a significant difference in the microbiota diversity was observed in the classification according to the disease severity. Immediately after the disease onset, remarkable changes were observed in the gut microbiota of PLWH-CoV, and the changing with a decrease in some short-chain fatty acid-producing bacteria and an increase in colitis-related pathobiont. In the second week after disease onset, relative amounts of specific bacteria distinguished between disease severity. One month after the disease onset, dysbiosis of the gut microbiota persisted, and the number of Enterobacteriaceae, mainly Escherichia-Shigella , which is potentially pathogenic, increased and were enriched in patients who developed post-acute sequelae of COVID-19 (PASC). Conclusion The changes in the gut microbiota associated with SARS-CoV-2 infection observed in PLWH in this study indicated a persistent decrease in SCFA-producing bacteria and an intestinal environment with an increase in opportunistic pathogens associated with enteritis. This report demonstrates that the intestinal environment in PLWH tends to show delayed improvement even after COVID-19 recovery, and highlights the importance of the dysbiosis associated with SARS-CoV-2 infection as a potential factor in the COVID-19 severity and the PASC in PLWH.
People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed the temporal changes in the gut microbiota composition of hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and their correlation with COVID-19 severity. The 16S rRNA analysis results using stool samples (along the timeline from disease onset) from 12 hospitalized PLWH-CoV, whose median CD4 + T cell count was 671 cells/µl, were compared to those of 19 healthy people and 25 PLWH. Bacterial diversity in PLWH-CoV is not significantly different from that of healthy people and SARS-CoV-2 non-infected PLWH, but a significant difference in the microbiota diversity was observed in the classification according to the disease severity. Immediately after the disease onset, remarkable changes were observed in the gut microbiota of PLWH-CoV, and the changing with a decrease in some short-chain fatty acid-producing bacteria and an increase in colitis-related pathobiont. In the second week after disease onset, relative amounts of specific bacteria distinguished between disease severity. One month after the disease onset, dysbiosis of the gut microbiota persisted, and the number of Enterobacteriaceae, mainly Escherichia-Shigella, which is potentially pathogenic, increased and were enriched in patients who developed post-acute sequelae of COVID-19 (PASC). The changes in the gut microbiota associated with SARS-CoV-2 infection observed in PLWH in this study indicated a persistent decrease in SCFA-producing bacteria and an intestinal environment with an increase in opportunistic pathogens associated with enteritis. This report demonstrates that the intestinal environment in PLWH tends to show delayed improvement even after COVID-19 recovery, and highlights the importance of the dysbiosis associated with SARS-CoV-2 infection as a potential factor in the COVID-19 severity and the PASC in PLWH.
BackgroundPeople living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed the temporal changes in the gut microbiota composition of hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and their correlation with COVID-19 severity.ResultThe 16S rRNA analysis results using stool samples (along the timeline from disease onset) from 12 hospitalized PLWH-CoV, whose median CD4 + T cell count was 671 cells/µl, were compared to those of 19 healthy people and 25 PLWH. Bacterial diversity in PLWH-CoV is not significantly different from that of healthy people and SARS-CoV-2 non-infected PLWH, but a significant difference in the microbiota diversity was observed in the classification according to the disease severity. Immediately after the disease onset, remarkable changes were observed in the gut microbiota of PLWH-CoV, and the changing with a decrease in some short-chain fatty acid-producing bacteria and an increase in colitis-related pathobiont. In the second week after disease onset, relative amounts of specific bacteria distinguished between disease severity. One month after the disease onset, dysbiosis of the gut microbiota persisted, and the number of Enterobacteriaceae, mainly Escherichia-Shigella, which is potentially pathogenic, increased and were enriched in patients who developed post-acute sequelae of COVID-19 (PASC).ConclusionThe changes in the gut microbiota associated with SARS-CoV-2 infection observed in PLWH in this study indicated a persistent decrease in SCFA-producing bacteria and an intestinal environment with an increase in opportunistic pathogens associated with enteritis. This report demonstrates that the intestinal environment in PLWH tends to show delayed improvement even after COVID-19 recovery, and highlights the importance of the dysbiosis associated with SARS-CoV-2 infection as a potential factor in the COVID-19 severity and the PASC in PLWH.
Abstract Background People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed the temporal changes in the gut microbiota composition of hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and their correlation with COVID-19 severity. Result The 16S rRNA analysis results using stool samples (along the timeline from disease onset) from 12 hospitalized PLWH-CoV, whose median CD4 + T cell count was 671 cells/µl, were compared to those of 19 healthy people and 25 PLWH. Bacterial diversity in PLWH-CoV is not significantly different from that of healthy people and SARS-CoV-2 non-infected PLWH, but a significant difference in the microbiota diversity was observed in the classification according to the disease severity. Immediately after the disease onset, remarkable changes were observed in the gut microbiota of PLWH-CoV, and the changing with a decrease in some short-chain fatty acid-producing bacteria and an increase in colitis-related pathobiont. In the second week after disease onset, relative amounts of specific bacteria distinguished between disease severity. One month after the disease onset, dysbiosis of the gut microbiota persisted, and the number of Enterobacteriaceae, mainly Escherichia-Shigella, which is potentially pathogenic, increased and were enriched in patients who developed post-acute sequelae of COVID-19 (PASC). Conclusion The changes in the gut microbiota associated with SARS-CoV-2 infection observed in PLWH in this study indicated a persistent decrease in SCFA-producing bacteria and an intestinal environment with an increase in opportunistic pathogens associated with enteritis. This report demonstrates that the intestinal environment in PLWH tends to show delayed improvement even after COVID-19 recovery, and highlights the importance of the dysbiosis associated with SARS-CoV-2 infection as a potential factor in the COVID-19 severity and the PASC in PLWH.
Background People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of their gut microbiota on COVID-19 is not fully elucidated. Here, we analyzed the temporal changes in the gut microbiota composition of hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected PLWH (PLWH-CoV) and their correlation with COVID-19 severity. Result The 16S rRNA analysis results using stool samples (along the timeline from disease onset) from 12 hospitalized PLWH-CoV, whose median CD4 + T cell count was 671 cells/[micro]l, were compared to those of 19 healthy people and 25 PLWH. Bacterial diversity in PLWH-CoV is not significantly different from that of healthy people and SARS-CoV-2 non-infected PLWH, but a significant difference in the microbiota diversity was observed in the classification according to the disease severity. Immediately after the disease onset, remarkable changes were observed in the gut microbiota of PLWH-CoV, and the changing with a decrease in some short-chain fatty acid-producing bacteria and an increase in colitis-related pathobiont. In the second week after disease onset, relative amounts of specific bacteria distinguished between disease severity. One month after the disease onset, dysbiosis of the gut microbiota persisted, and the number of Enterobacteriaceae, mainly Escherichia-Shigella, which is potentially pathogenic, increased and were enriched in patients who developed post-acute sequelae of COVID-19 (PASC). Conclusion The changes in the gut microbiota associated with SARS-CoV-2 infection observed in PLWH in this study indicated a persistent decrease in SCFA-producing bacteria and an intestinal environment with an increase in opportunistic pathogens associated with enteritis. This report demonstrates that the intestinal environment in PLWH tends to show delayed improvement even after COVID-19 recovery, and highlights the importance of the dysbiosis associated with SARS-CoV-2 infection as a potential factor in the COVID-19 severity and the PASC in PLWH. Keywords: SARS-CoV-2, COVID-19, HIV, Microbiota, Post-acute COVID-19 syndrome
ArticleNumber 6
Audience Academic
Author Ishizaka, Aya
Koga, Michiko
Suzuki, Yutaka
Kawaoka, Yoshihiro
Yotsuyanagi, Hiroshi
Adachi, Eisuke
Iwatsuki-Horimoto, Kiyoko
Yamayoshi, Seiya
Mizutani, Taketoshi
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  organization: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, 6-2-3 Kashiwanoha, 277-0882, Kashiwa-shi, Chiba, Japan. mizutanitaketoshi@g.ecc.u-tokyo.ac.jp
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  fullname: Kawaoka, Yoshihiro
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  organization: Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, the University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108-8639, Tokyo, Japan. yotsudid@ims.u-tokyo.ac.jp
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Cites_doi 10.7448/IAS.20.1.21526
10.1038/nm1511
10.1093/cid/ciaa1605
10.1016/S2352-3018(20)30164-8
10.1128/JCM.02926-14
10.1038/mi.2016.97
10.3389/fmicb.2017.02114
10.5888/pcd18.210123
10.1016/S2352-3018(22)00097-2
10.1093/cid/cir627
10.1038/ni.3400
10.1038/s41467-022-34260-2
10.1177/0956462420973106
10.1016/j.ijid.2022.05.055
10.1128/Spectrum.00708-21
10.3390/v14030493
10.1093/cid/ciaa709
10.1038/nature12721
10.1371/journal.pcbi.1009442
10.1111/hiv.13174
10.1016/j.ebiom.2019.07.027
10.1186/s40001-022-00824-7
10.1016/j.cell.2021.05.023
10.1038/nature12726
10.1038/s41598-020-76474-8
10.1128/spectrum.01926-22
10.1186/s12985-023-02113-z
10.1186/s40168-018-0580-7
10.1056/NEJMcp2009249
10.1093/infdis/jit025
10.1038/s41587-020-0548-6
10.1038/s41598-020-59937-w
10.1038/s41587-019-0209-9
10.1007/s40121-022-00654-4
10.1038/nmeth.3869
10.1038/s41392-023-01445-0
10.1038/s41422-020-0332-7
10.1016/j.chom.2021.11.001
10.1093/nar/gks808
10.1007/s11904-022-00618-w
10.1177/17562848221118403
10.1016/j.neurobiolaging.2016.08.019
10.7189/jogh.12.05036
10.1016/S2352-3018(20)30305-2
10.1136/gutjnl-2020-323020
10.1016/j.cell.2013.12.016
10.1016/j.gtc.2010.12.009
10.1093/nar/28.1.27
10.1172/JCI72330
10.1097/QAD.0000000000003132
10.3390/v13102101
10.1002/eji.202250163
10.1186/s13098-018-0312-y
10.1016/j.ebiom.2016.01.032
10.1093/cid/ciaa635
10.1186/gb-2011-12-6-r60
10.1038/s41467-020-16222-8
10.1038/s41467-020-18262-6
10.1136/gutjnl-2021-325989
10.1007/978-3-319-49688-7_4
10.1128/spectrum.01689-21
10.1186/s12866-020-02074-1
10.1097/MIB.0000000000000972
10.3390/v14050950
10.3389/fimmu.2020.00827
10.3201/eid2710.211461
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Issue 1
Keywords COVID-19
Microbiota
SARS-CoV-2
HIV
Post-acute COVID-19 syndrome
Language English
License 2023. The Author(s).
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References D Zheng (3157_CR16) 2020; 30
A Kaul (3157_CR65) 2017; 8
G Favara (3157_CR12) 2022; 12
I Vujkovic-Cvijin (3157_CR27) 2020; 11
B Diao (3157_CR37) 2020; 11
S Gu (3157_CR39) 2020; 71
M Alexander (3157_CR46) 2022; 30
H Seong (3157_CR17) 2023; 8
P Villoslada-Blanco (3157_CR57) 2022; 11
K Bhaskaran (3157_CR4) 2021; 8
CF Kelley (3157_CR25) 2017; 10
EM Quigley (3157_CR50) 2011; 40
ME Ceballos (3157_CR6) 2021; 32
AM Geretti (3157_CR5) 2021; 73
A Choudhury (3157_CR35) 2022; 15
W Yang (3157_CR51) 2020; 11
C Quast (3157_CR63) 2013; 41
K Takeshita (3157_CR41) 2016; 22
MR Stutz (3157_CR48) 2022; 13
A Ishizaka (3157_CR20) 2021; 9
T Zuo (3157_CR40) 2021; 70
G Mendez-Lagares (3157_CR31) 2013; 207
ND Mathewson (3157_CR42) 2016; 17
DD Bosho (3157_CR30) 2018; 10
M Kanehisa (3157_CR67) 2000; 28
S SeyedAlinaghi (3157_CR14) 2022; 27
K Nganou-Makamdop (3157_CR23) 2021; 184
T Mizutani (3157_CR32) 2022; 10
Y Sekido (3157_CR53) 2020; 10
N Shalev (3157_CR9) 2020; 71
E Bolyen (3157_CR61) 2019; 37
S Bertagnolio (3157_CR7) 2022; 9
A Bachelard (3157_CR11) 2022; 122
N Arpaia (3157_CR44) 2013; 504
JJ Taitz (3157_CR56) 2023; 53
L Kompaniyets (3157_CR1) 2021; 18
BJ Callahan (3157_CR62) 2016; 13
F Pedregosa (3157_CR64) 2011; 12
GM Douglas (3157_CR66) 2020; 38
N Segata (3157_CR68) 2011; 12
P Vizcarra (3157_CR10) 2020; 7
A Ishizaka (3157_CR29) 2021; 13
BJ Gardiner (3157_CR47) 2015; 53
MJ Villanueva-Millan (3157_CR58) 2017; 20
JM Brenchley (3157_CR19) 2006; 12
AJS Armstrong (3157_CR24) 2018; 6
I Al Kassaa (3157_CR49) 2017
J Del Amo (3157_CR15) 2022; 36
MH Kim (3157_CR36) 2020; 10
T Mizutani (3157_CR21) 2022; 14
RT Gandhi (3157_CR59) 2020; 383
G Guaraldi (3157_CR2) 2011; 53
MA Spinelli (3157_CR3) 2022; 19
SR Dalal (3157_CR52) 2014; 124
A Cattaneo (3157_CR54) 2017; 49
Y Furusawa (3157_CR45) 2013; 504
A Klindworth (3157_CR60) 2013; 41
F De Vadder (3157_CR43) 2014; 156
YK Yeoh (3157_CR33) 2021; 70
Y Xie (3157_CR22) 2021; 21
SA Hoffman (3157_CR13) 2021; 27
A Ishizaka (3157_CR18) 2023; 20
M Mazzitelli (3157_CR38) 2022; 14
M Noguera-Julian (3157_CR26) 2016; 5
J Alzahrani (3157_CR28) 2019; 46
Q Liu (3157_CR34) 2022; 71
MJ Lee (3157_CR8) 2022; 23
S Li (3157_CR55) 2022; 10
H Mallick (3157_CR69) 2021; 17
References_xml – volume: 20
  start-page: 21526
  issue: 1
  year: 2017
  ident: 3157_CR58
  publication-title: J Int AIDS Soc
  doi: 10.7448/IAS.20.1.21526
  contributor:
    fullname: MJ Villanueva-Millan
– volume: 12
  start-page: 1365
  issue: 12
  year: 2006
  ident: 3157_CR19
  publication-title: Nat Med
  doi: 10.1038/nm1511
  contributor:
    fullname: JM Brenchley
– volume: 73
  start-page: e2095
  issue: 7
  year: 2021
  ident: 3157_CR5
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciaa1605
  contributor:
    fullname: AM Geretti
– volume: 7
  start-page: e554
  issue: 8
  year: 2020
  ident: 3157_CR10
  publication-title: Lancet HIV
  doi: 10.1016/S2352-3018(20)30164-8
  contributor:
    fullname: P Vizcarra
– volume: 53
  start-page: 626
  issue: 2
  year: 2015
  ident: 3157_CR47
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.02926-14
  contributor:
    fullname: BJ Gardiner
– volume: 10
  start-page: 996
  issue: 4
  year: 2017
  ident: 3157_CR25
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2016.97
  contributor:
    fullname: CF Kelley
– volume: 8
  start-page: 2114
  year: 2017
  ident: 3157_CR65
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2017.02114
  contributor:
    fullname: A Kaul
– volume: 18
  start-page: E66
  year: 2021
  ident: 3157_CR1
  publication-title: Prev Chronic Dis
  doi: 10.5888/pcd18.210123
  contributor:
    fullname: L Kompaniyets
– volume: 9
  start-page: e486
  issue: 7
  year: 2022
  ident: 3157_CR7
  publication-title: Lancet HIV
  doi: 10.1016/S2352-3018(22)00097-2
  contributor:
    fullname: S Bertagnolio
– volume: 12
  start-page: 2825
  year: 2011
  ident: 3157_CR64
  publication-title: JMLR
  contributor:
    fullname: F Pedregosa
– volume: 53
  start-page: 1120
  issue: 11
  year: 2011
  ident: 3157_CR2
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/cir627
  contributor:
    fullname: G Guaraldi
– volume: 17
  start-page: 505
  issue: 5
  year: 2016
  ident: 3157_CR42
  publication-title: Nat Immunol
  doi: 10.1038/ni.3400
  contributor:
    fullname: ND Mathewson
– volume: 13
  start-page: 6615
  issue: 1
  year: 2022
  ident: 3157_CR48
  publication-title: Nat Commun
  doi: 10.1038/s41467-022-34260-2
  contributor:
    fullname: MR Stutz
– volume: 32
  start-page: 435
  issue: 5
  year: 2021
  ident: 3157_CR6
  publication-title: Int J STD AIDS
  doi: 10.1177/0956462420973106
  contributor:
    fullname: ME Ceballos
– volume: 122
  start-page: 152
  year: 2022
  ident: 3157_CR11
  publication-title: Int J Infect Dis
  doi: 10.1016/j.ijid.2022.05.055
  contributor:
    fullname: A Bachelard
– volume: 9
  start-page: e0070821
  issue: 1
  year: 2021
  ident: 3157_CR20
  publication-title: Microbiol Spectr
  doi: 10.1128/Spectrum.00708-21
  contributor:
    fullname: A Ishizaka
– volume: 14
  start-page: 493
  issue: 3
  year: 2022
  ident: 3157_CR38
  publication-title: Viruses
  doi: 10.3390/v14030493
  contributor:
    fullname: M Mazzitelli
– volume: 71
  start-page: 2669
  issue: 10
  year: 2020
  ident: 3157_CR39
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciaa709
  contributor:
    fullname: S Gu
– volume: 504
  start-page: 446
  issue: 7480
  year: 2013
  ident: 3157_CR45
  publication-title: Nature
  doi: 10.1038/nature12721
  contributor:
    fullname: Y Furusawa
– volume: 17
  start-page: e1009442
  issue: 11
  year: 2021
  ident: 3157_CR69
  publication-title: PLoS Comput Biol
  doi: 10.1371/journal.pcbi.1009442
  contributor:
    fullname: H Mallick
– volume: 23
  start-page: 121
  issue: 2
  year: 2022
  ident: 3157_CR8
  publication-title: HIV Med
  doi: 10.1111/hiv.13174
  contributor:
    fullname: MJ Lee
– volume: 46
  start-page: 522
  year: 2019
  ident: 3157_CR28
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2019.07.027
  contributor:
    fullname: J Alzahrani
– volume: 27
  start-page: 195
  issue: 1
  year: 2022
  ident: 3157_CR14
  publication-title: Eur J Med Res
  doi: 10.1186/s40001-022-00824-7
  contributor:
    fullname: S SeyedAlinaghi
– volume: 184
  start-page: 3899
  issue: 15
  year: 2021
  ident: 3157_CR23
  publication-title: Cell
  doi: 10.1016/j.cell.2021.05.023
  contributor:
    fullname: K Nganou-Makamdop
– volume: 504
  start-page: 451
  issue: 7480
  year: 2013
  ident: 3157_CR44
  publication-title: Nature
  doi: 10.1038/nature12726
  contributor:
    fullname: N Arpaia
– volume: 10
  start-page: 19417
  issue: 1
  year: 2020
  ident: 3157_CR36
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-76474-8
  contributor:
    fullname: MH Kim
– volume: 10
  start-page: e0192622
  issue: 6
  year: 2022
  ident: 3157_CR55
  publication-title: Microbiol Spectr
  doi: 10.1128/spectrum.01926-22
  contributor:
    fullname: S Li
– volume: 20
  start-page: 146
  issue: 1
  year: 2023
  ident: 3157_CR18
  publication-title: Virol J
  doi: 10.1186/s12985-023-02113-z
  contributor:
    fullname: A Ishizaka
– volume: 6
  start-page: 198
  issue: 1
  year: 2018
  ident: 3157_CR24
  publication-title: Microbiome
  doi: 10.1186/s40168-018-0580-7
  contributor:
    fullname: AJS Armstrong
– volume: 383
  start-page: 1757
  issue: 18
  year: 2020
  ident: 3157_CR59
  publication-title: N Engl J Med
  doi: 10.1056/NEJMcp2009249
  contributor:
    fullname: RT Gandhi
– volume: 207
  start-page: 1221
  issue: 8
  year: 2013
  ident: 3157_CR31
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jit025
  contributor:
    fullname: G Mendez-Lagares
– volume: 38
  start-page: 685
  issue: 6
  year: 2020
  ident: 3157_CR66
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-020-0548-6
  contributor:
    fullname: GM Douglas
– volume: 10
  start-page: 2988
  issue: 1
  year: 2020
  ident: 3157_CR53
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-59937-w
  contributor:
    fullname: Y Sekido
– volume: 37
  start-page: 852
  issue: 8
  year: 2019
  ident: 3157_CR61
  publication-title: Nat Biotechnol
  doi: 10.1038/s41587-019-0209-9
  contributor:
    fullname: E Bolyen
– volume: 11
  start-page: 1541
  issue: 4
  year: 2022
  ident: 3157_CR57
  publication-title: Infect Dis Ther
  doi: 10.1007/s40121-022-00654-4
  contributor:
    fullname: P Villoslada-Blanco
– volume: 13
  start-page: 581
  issue: 7
  year: 2016
  ident: 3157_CR62
  publication-title: Nat Methods
  doi: 10.1038/nmeth.3869
  contributor:
    fullname: BJ Callahan
– volume: 8
  start-page: 178
  issue: 1
  year: 2023
  ident: 3157_CR17
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-023-01445-0
  contributor:
    fullname: H Seong
– volume: 41
  start-page: D590
  issue: Database issue
  year: 2013
  ident: 3157_CR63
  publication-title: Nucleic Acids Res
  contributor:
    fullname: C Quast
– volume: 30
  start-page: 492
  issue: 6
  year: 2020
  ident: 3157_CR16
  publication-title: Cell Res
  doi: 10.1038/s41422-020-0332-7
  contributor:
    fullname: D Zheng
– volume: 30
  start-page: 17
  issue: 1
  year: 2022
  ident: 3157_CR46
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2021.11.001
  contributor:
    fullname: M Alexander
– volume: 41
  start-page: e1
  issue: 1
  year: 2013
  ident: 3157_CR60
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gks808
  contributor:
    fullname: A Klindworth
– volume: 19
  start-page: 425
  issue: 5
  year: 2022
  ident: 3157_CR3
  publication-title: Curr HIV/AIDS Rep
  doi: 10.1007/s11904-022-00618-w
  contributor:
    fullname: MA Spinelli
– volume: 15
  start-page: 175628482211184
  year: 2022
  ident: 3157_CR35
  publication-title: Therap Adv Gastroenterol
  doi: 10.1177/17562848221118403
  contributor:
    fullname: A Choudhury
– volume: 49
  start-page: 60
  year: 2017
  ident: 3157_CR54
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2016.08.019
  contributor:
    fullname: A Cattaneo
– volume: 12
  start-page: 05036
  year: 2022
  ident: 3157_CR12
  publication-title: J Glob Health
  doi: 10.7189/jogh.12.05036
  contributor:
    fullname: G Favara
– volume: 8
  start-page: e24
  issue: 1
  year: 2021
  ident: 3157_CR4
  publication-title: Lancet HIV
  doi: 10.1016/S2352-3018(20)30305-2
  contributor:
    fullname: K Bhaskaran
– volume: 70
  start-page: 698
  issue: 4
  year: 2021
  ident: 3157_CR33
  publication-title: Gut
  doi: 10.1136/gutjnl-2020-323020
  contributor:
    fullname: YK Yeoh
– volume: 156
  start-page: 84
  issue: 1–2
  year: 2014
  ident: 3157_CR43
  publication-title: Cell
  doi: 10.1016/j.cell.2013.12.016
  contributor:
    fullname: F De Vadder
– volume: 40
  start-page: 207
  issue: 1
  year: 2011
  ident: 3157_CR50
  publication-title: Gastroenterol Clin
  doi: 10.1016/j.gtc.2010.12.009
  contributor:
    fullname: EM Quigley
– volume: 28
  start-page: 27
  issue: 1
  year: 2000
  ident: 3157_CR67
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/28.1.27
  contributor:
    fullname: M Kanehisa
– volume: 124
  start-page: 4190
  issue: 10
  year: 2014
  ident: 3157_CR52
  publication-title: J Clin Invest
  doi: 10.1172/JCI72330
  contributor:
    fullname: SR Dalal
– volume: 36
  start-page: 161
  issue: 2
  year: 2022
  ident: 3157_CR15
  publication-title: AIDS
  doi: 10.1097/QAD.0000000000003132
  contributor:
    fullname: J Del Amo
– volume: 13
  start-page: 2101
  issue: 10
  year: 2021
  ident: 3157_CR29
  publication-title: Viruses
  doi: 10.3390/v13102101
  contributor:
    fullname: A Ishizaka
– volume: 53
  start-page: e2250163
  year: 2023
  ident: 3157_CR56
  publication-title: Eur J Immunol.
  doi: 10.1002/eji.202250163
  contributor:
    fullname: JJ Taitz
– volume: 70
  start-page: 276
  issue: 2
  year: 2021
  ident: 3157_CR40
  publication-title: Gut
  contributor:
    fullname: T Zuo
– volume: 10
  start-page: 10
  year: 2018
  ident: 3157_CR30
  publication-title: Diabetol Metab Syndr
  doi: 10.1186/s13098-018-0312-y
  contributor:
    fullname: DD Bosho
– volume: 5
  start-page: 135
  year: 2016
  ident: 3157_CR26
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2016.01.032
  contributor:
    fullname: M Noguera-Julian
– volume: 71
  start-page: 2294
  issue: 16
  year: 2020
  ident: 3157_CR9
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/ciaa635
  contributor:
    fullname: N Shalev
– volume: 12
  start-page: R60
  issue: 6
  year: 2011
  ident: 3157_CR68
  publication-title: Genome Biol
  doi: 10.1186/gb-2011-12-6-r60
  contributor:
    fullname: N Segata
– volume: 11
  start-page: 2448
  issue: 1
  year: 2020
  ident: 3157_CR27
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-16222-8
  contributor:
    fullname: I Vujkovic-Cvijin
– volume: 11
  start-page: 4457
  issue: 1
  year: 2020
  ident: 3157_CR51
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-18262-6
  contributor:
    fullname: W Yang
– volume: 71
  start-page: 544
  issue: 3
  year: 2022
  ident: 3157_CR34
  publication-title: Gut
  doi: 10.1136/gutjnl-2021-325989
  contributor:
    fullname: Q Liu
– start-page: 83
  volume-title: New insights on antiviral probiotics: from research to applications
  year: 2017
  ident: 3157_CR49
  doi: 10.1007/978-3-319-49688-7_4
  contributor:
    fullname: I Al Kassaa
– volume: 10
  start-page: e0168921
  issue: 2
  year: 2022
  ident: 3157_CR32
  publication-title: Microbiol Spectr
  doi: 10.1128/spectrum.01689-21
  contributor:
    fullname: T Mizutani
– volume: 21
  start-page: 11
  issue: 1
  year: 2021
  ident: 3157_CR22
  publication-title: BMC Microbiol
  doi: 10.1186/s12866-020-02074-1
  contributor:
    fullname: Y Xie
– volume: 22
  start-page: 2802
  issue: 12
  year: 2016
  ident: 3157_CR41
  publication-title: Inflamm Bowel Dis
  doi: 10.1097/MIB.0000000000000972
  contributor:
    fullname: K Takeshita
– volume: 14
  start-page: 950
  issue: 5
  year: 2022
  ident: 3157_CR21
  publication-title: Viruses
  doi: 10.3390/v14050950
  contributor:
    fullname: T Mizutani
– volume: 11
  start-page: 827
  year: 2020
  ident: 3157_CR37
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.00827
  contributor:
    fullname: B Diao
– volume: 27
  start-page: 2720
  issue: 10
  year: 2021
  ident: 3157_CR13
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid2710.211461
  contributor:
    fullname: SA Hoffman
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Snippet People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the impact of...
Abstract Background People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity;...
Background People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the...
BackgroundPeople living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the...
BACKGROUNDPeople living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity; however, the...
Abstract Background People living with HIV (PLWH) with chronic inflammation may have an increasing risk for coronavirus disease 2019 (COVID-19) severity;...
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StartPage 6
SubjectTerms Age
Bacteria
Care and treatment
CD4 antigen
Colitis
Comparative analysis
Complications
Coronaviruses
COVID-19
COVID-19 - complications
Development and progression
Digestive system
Dysbacteriosis
Dysbiosis
Enteritis
Fatty acids
Gastrointestinal Microbiome
Gastrointestinal tract
Health aspects
Hepatitis A
HIV
HIV (Viruses)
HIV Infections - complications
HIV patients
Homeostasis
Hospitals
Human immunodeficiency virus
Humans
Immunology
Infections
Inflammation
Inflammatory bowel disease
Intestinal microflora
Intestine
Lymphocytes
Lymphocytes T
Medical research
Medicine, Experimental
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
Opportunist infection
Pathogenesis
Patients
Physiological aspects
Post-acute COVID-19 syndrome
Respiratory diseases
RNA
RNA, Ribosomal, 16S - genetics
rRNA 16S
SARS-CoV-2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
T cells
Viral diseases
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Title Association of gut microbiota with the pathogenesis of SARS-CoV-2 Infection in people living with HIV
URI https://www.ncbi.nlm.nih.gov/pubmed/38172680
https://www.proquest.com/docview/2914284178
https://search.proquest.com/docview/2910191993
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Volume 24
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