Tumor-infiltrating B cells in non-small cell lung cancer: current insights and future directions

• Published in: Cancer cell international Vol. 25; no. 1; pp. 68 - 14
• Main Authors: Jiang, Shuyue, Zhu, Daxing, Wang, Ye
• Format: Journal Article
• Language: English
• Published: England BioMed Central 26.02.2025; BMC
• Subjects: Antigens; Apoptosis; Bone marrow; Cancer therapies; Chemokines; Cytokines; Dendritic cells; Genes; Genotype & phenotype; Humoral immunity; Immunoglobulins; Lung cancer; Lymphocytes; Lymphocytes B; Non-small cell lung carcinoma; Non-small-cell lung cancer; Phenotypes; Plasma; Review; Signal transduction; Small cell lung carcinoma; Tumor microenvironment; Tumor-infiltrating B lymphocyte; Tumor-infiltrating lymphocytes; Tumors; Non-small-cell lung cancer; Tumor microenvironment; Humoral immunity; Tumor-infiltrating B lymphocyte
• ISSN: 1475-2867; 1475-2867
• DOI: 10.1186/s12935-025-03668-3

Tumor-infiltrating immune cells have been widely recognized as playing an important role in the promotion or inhibition of tumor growth. Recently there has been increasing attention on tumor-infiltrating B cells in the tumor microenvironment. However, the role of B cells in non-small cell lung cancer remains largely unknown. Reviewing recent studies, here we describe the distribution, phenotype, and heterogeneity of B lymphocytes in the non-small cell lung cancer, present their functions and discuss the prognostic significance of the different B-cell subtypes as well as potential therapeutic strategies targeting TIL-Bs. Finally, the review highlights the need for future research to further elucidate their precise function in the tumor microenvironment.