Association between OX40L polymorphism and type 2 diabetes mellitus in Iranians

• Published in: BMC medical genomics Vol. 17; no. 1; pp. 184 - 9
• Main Authors: Jahromi, Abdolreza Sotoodeh, Erfanian, Saiedeh, Roustazadeh, Abazar
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.07.2024; BioMed Central; BMC
• Subjects: Adult; Amino acids; Analysis; Antigens; Autoimmune diseases; Body fat; Body mass index; Case-Control Studies; Cholesterol; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diagnosis; Disease; Environmental factors; Female; Gene Frequency; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Haplotypes; Health aspects; High density lipoprotein; Humans; Inflammation; Insulin resistance; Internet software; Iran; Linkage Disequilibrium; Male; Medical research; Medicine, Experimental; Middle Aged; Middle East; Middle Eastern People; Morbidity; Mortality; OX40 Ligand - genetics; OX40L; Ox40L protein; Phenotypes; Phenotypic variations; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Restriction fragment length polymorphism; Statistical analysis; Tumor necrosis factor; Tumor necrosis factor-TNF; Type 2 diabetes; Iran; Middle East; OX40L; Diabetes mellitus; Polymorphism

Diabetes mellitus (DM) is one of the leading causes of morbidity and mortality worldwide. It is a multifactorial disease that genetic and environmental factors contribute to its development. The aim of the study was to investigate the association of OX40L promoter gene polymorphisms with type 2 diab...