Immune alterations and overexpression of CTCF in endometrial carcinoma: insights from molecular subtyping

• Published in: Cancer cell international Vol. 24; no. 1; pp. 392 - 14
• Main Authors: Wei, Caiping, Chen, Guowei, Chen, Kun, Fang, Shuang, He, Hongying
• Format: Journal Article
• Language: English
• Published: England BioMed Central 02.12.2024; BMC
• Subjects: Apoptosis; Cancer therapies; Chemotherapy; Cluster analysis; CTCF; CTCF gene; DEGs; Endometrial cancer; Endometrium; Estrogens; Gene expression; Genetic factors; Gynecology; Immune checkpoint; Immunohistochemistry; Intracellular signalling; Malignancy; Medical diagnosis; Medical prognosis; Metastases; Molecular subtyping; Mutation; Patients; Polymerase chain reaction; Radiation therapy; Survival analysis; Therapeutic targets; Transcriptomics; Tumors; Uterine cancer; Western blotting; Wound healing; United Kingdom > UK; United States > US; China; Shanghai China; DEGs; CTCF; Endometrial cancer; Molecular subtyping

Endometrial cancer (EC) is a prevalent epithelial malignancy originating in the female endometrium, and its global incidence has been on the rise over the past decade. Despite significant scientific progress has been achieved recently, the genetic factors underlying EC pathogenesis remain poorly und...