Peptidoglycan endopeptidase MepM of uropathogenic Escherichia coli contributes to competitive fitness during urinary tract infections

• Published in: BMC microbiology Vol. 24; no. 1; pp. 190 - 15
• Main Authors: Huang, Wen-Chun, Dwija, Ida Bagus Nyoman Putra, Hashimoto, Masayuki, Wu, Jiunn-Jong, Wang, Ming-Cheng, Kao, Cheng-Yen, Lin, Wei-Hung, Wang, Shuying, Teng, Ching-Hao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.05.2024; BioMed Central; BMC
• Subjects: Animals; Antibiotic resistance; Antibiotics; Bacteria; Bacterial diseases; Bacterial infections; Bladder; Care and treatment; Diagnosis; Disease Models, Animal; E coli; Endopeptidases; Endopeptidases - genetics; Endopeptidases - metabolism; Enzymes; Escherichia coli; Escherichia coli Infections - microbiology; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Female; Health aspects; Humans; Immune system; Investigations; Macrophages; Macrophages - immunology; Macrophages - microbiology; MepM; MepS; Mice; Morphology; Motility; Pathogenesis; Pathogens; Peptides; Peptidoglycan - metabolism; Peptidoglycan endopeptidase; Peptidoglycans; Phagocytosis; Public health; Spr; Urinary tract; Urinary tract diseases; Urinary tract infections; Urinary Tract Infections - microbiology; Urine; Urogenital system; Uropathogenic E. Coli; Uropathogenic Escherichia coli - drug effects; Uropathogenic Escherichia coli - enzymology; Uropathogenic Escherichia coli - genetics; Uropathogenic Escherichia coli - pathogenicity; Virulence; YebA; Taiwan; MepM; Urinary tract infection; Uropathogenic E. Coli; YebA; Spr; Pathogenesis; Peptidoglycan endopeptidase; UTI; UPEC; MepS

Urinary tract infections (UTIs) are common bacterial infections, primarily caused by uropathogenic Escherichia coli (UPEC), leading to significant health issues and economic burden. Although antibiotics have been effective in treating UPEC infections, the rise of antibiotic-resistant strains hinders...