First-in-patient study of OTL78 for intraoperative fluorescence imaging of prostate-specific membrane antigen-positive prostate cancer: a single-arm, phase 2a, feasibility trial

• Published in: The lancet oncology Vol. 24; no. 5; pp. 457 - 467
• Main Authors: Stibbe, Judith A, de Barros, Hilda A, Linders, Daan G J, Bhairosingh, Shadhvi S, Bekers, Elise M, van Leeuwen, Pim J, Low, Philip S, Kularatne, Sumith A, Vahrmeijer, Alexander L, Burggraaf, Jacobus, van der Poel, Henk G
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2023; Elsevier Limited
• Subjects: Adverse events; Aged; Antigens; Cancer surgery; Clinical trials; Dosage; Feasibility Studies; Fluorescence; Hematology, Oncology, and Palliative Medicine; Hemorrhage; Humans; Infrared imaging systems; Laboratories; Lymph nodes; Lymphatic system; Lymphocele; Male; Metastasis; Optical Imaging; Patients; Pharmacokinetics; Positron emission tomography; Positron Emission Tomography Computed Tomography; Prostate - pathology; Prostate cancer; Prostate-Specific Antigen; Prostatectomy; Prostatectomy - adverse effects; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - surgery; Robotic surgery; Surgery; Toxicity; Urological surgery; United States > US; Netherlands
• ISSN: 1470-2045; 1474-5488; 1474-5488
• DOI: 10.1016/S1470-2045(23)00102-X

Targeted real-time imaging during robot-assisted radical prostatectomy provides information on the localisation and extent of prostate cancer. We assessed the safety and feasibility of the prostate-specific membrane antigen (PSMA)-targeted fluorescent tracer OTL78 in patients with prostate cancer. I...