Characteristics of anticoagulant therapy and comorbidity related to overanticoagulation

• Published in: Thrombosis and haemostasis Vol. 86; no. 2; p. 569
• Main Authors: Penning-van Beest, F J, van Meegen, E, Rosendaal, F R, Stricker, B H
• Format: Journal Article
• Language: English
• Published: Germany 01.08.2001
• Subjects: Aged; Anticoagulants - adverse effects; Anticoagulants - standards; Anticoagulants - therapeutic use; Cardiovascular Diseases - complications; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - epidemiology; Case-Control Studies; Cohort Studies; Comorbidity; Coumarins - adverse effects; Coumarins - therapeutic use; Drug Monitoring; Drug Overdose - complications; Drug Overdose - etiology; Female; Hemorrhage - chemically induced; Hemorrhage - prevention & control; Humans; International Normalized Ratio; Male; Middle Aged; Netherlands - epidemiology; Prospective Studies; Risk Factors; Netherlands

The risk of hemorrhage when using coumarin anticoagulants sharply increases when the International Normalised Ratio (INR) is > or =6.0. We performed a prospective cohort study with a nested case-control design among 17,056 outpatients of an anticoagulation clinic to determine the incidence of ove...