The Encapsulation of Citicoline within Solid Lipid Nanoparticles Enhances Its Capability to Counteract the 6-Hydroxydopamine-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

• Published in: Pharmaceutics Vol. 14; no. 9; p. 1827
• Main Authors: Margari, Andrea, Monteduro, Anna Grazia, Rizzato, Silvia, Capobianco, Loredana, Crestini, Alessio, Rivabene, Roberto, Piscopo, Paola, D’Onofrio, Mara, Manzini, Valeria, Trapani, Giuseppe, Quarta, Alessandra, Maruccio, Giuseppe, Ventra, Carmelo, Lieto, Luigi, Trapani, Adriana
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 30.08.2022; MDPI
• Subjects: 6-hydroxydopamine; Bioavailability; Biomedical materials; Chemical properties; citicoline; Cytidine diphosphate choline; Degeneration; Dopamine; Drug delivery systems; Drugs; Health aspects; Homogenization; Lipids; Nanoparticles; Nervous system; Neuroblastoma; Oxidative stress; Parkinson's disease; Pharmaceutical industry; Pharmaceutical research; SH-SY5Y dopaminergic cells; solid lipid nanoparticles; Vehicles; Italy; Germany

(1) Backgrond: Considering the positive effects of citicoline (CIT) in the management of some neurodegenerative diseases, the aim of this work was to develop CIT-Loaded Solid Lipid Nanoparticles (CIT-SLNs) for enhancing the therapeutic use of CIT in parkinsonian syndrome; (2) Methods: CIT-SLNs were...